Effects of autapse and channel blockage on firing regularity in a biological neuronal network

In this paper; the effects of autapse (a kind of self-synapse formed between the axon of the soma of a neuron and its own dendrites) and ion channel blockage on the firing regularity of a biological small-world neuronal network, consists of stochastic Hodgkin-Huxley neurons, are studied. In this study, it is assumed that all of the neurons on the network have a chemical autapse and a constant membrane area. Obtained results indicate that there are different effects of channel blockage and parameters of the autapse on the regularity of the network, thus on the temporal coherence of the network. It is found that the firing regularity of the network is decreased with the sodium channel blockage while increased with potassium channel blockage. Besides, it is determined that regularity of the network augments with the conductance of the autapse.

Dergi Adı Istanbul University - Journal of Electrical and Electronics Engineering
Dergi Cilt Bilgisi 17
Sayfalar 3069 - 3073
Yayın Yılı 2017
Eser Adı
[dc.title]
Effects of autapse and channel blockage on firing regularity in a biological neuronal network
Yazar
[dc.contributor.author]
Uzun, Rukiye
Yazar
[dc.contributor.author]
Özer, Mahmut
Yayın Yılı
[dc.date.issued]
2017
Yayıncı
[dc.publisher]
Istanbul University
Yayın Türü
[dc.type]
proceedings
Özet
[dc.description.abstract]
In this paper; the effects of autapse (a kind of self-synapse formed between the axon of the soma of a neuron and its own dendrites) and ion channel blockage on the firing regularity of a biological small-world neuronal network, consists of stochastic Hodgkin-Huxley neurons, are studied. In this study, it is assumed that all of the neurons on the network have a chemical autapse and a constant membrane area. Obtained results indicate that there are different effects of channel blockage and parameters of the autapse on the regularity of the network, thus on the temporal coherence of the network. It is found that the firing regularity of the network is decreased with the sodium channel blockage while increased with potassium channel blockage. Besides, it is determined that regularity of the network augments with the conductance of the autapse.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Autapse
Konu Başlıkları
[dc.subject]
Channel blocking
Konu Başlıkları
[dc.subject]
Ion channel noise
Konu Başlıkları
[dc.subject]
Small-world neuronal netwoks
Künye
[dc.identifier.citation]
Uzun, R. ve Özer, M. (2016). Effects of autapse and channel blockage on firing regularity in a biological neuronal network. 2016 Medical Technologies National Congress (TIPTEKNO) içinde (ss. 1–4). doi:10.1109/TIPTEKNO.2016.7863099
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
1303-0914
İlk Sayfa Sayısı
[dc.identifier.startpage]
3069
Son Sayfa Sayısı
[dc.identifier.endpage]
3073
Dergi Adı
[dc.relation.journal]
Istanbul University - Journal of Electrical and Electronics Engineering
Dergi Cilt Bilgisi
[dc.identifier.volume]
17
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/5436
Tek Biçim Adres
[dc.identifier.uri]
https://doi.org/10.1109/TIPTEKNO.2016.7863099
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
32
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
07 Şubat 2024 23:33
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Tıklayınız
network blockage autapse channel regularity firing neurons effects dendrites) Obtained results indicate different parameters temporal coherence membrane decreased sodium increased potassium Besides determined augments conductance constant consists neuron biological small-world neuronal between stochastic chemical Hodgkin-Huxley
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