Pretreatment with adenosine and adenosine A1 receptor agonist protects againts intestinal ischemia-reperfusion injury in rat

Aim: To examine the effects of adenosine and A1 receptor activation on reperfusion-induced small intestinal injury. Methods: Rats were randomized into groups with sham operation, ischemia and reperfusion, and systemic treatments with either adenosine or 2-chloro-N6-cyclopentyladenosine, A1 receptor agonist or 8-cyclopentyl-1,3-dipropylxanthine, A1 receptor antagonist, plus adenosine before ischemia. Following reperfusion, contractions of ileum segments in response to KCI, carbachol and substance P were recorded. Tissue myeloperoxidase, malondialdehyde, and reduced glutathione levels were measured. Results: Ischemia significantly decreased both contraction and reduced glutathione level which were ameliorated by adenosine and agonist administration. Treatment also decreased neutrophil infiltration and membrane lipid peroxidation. Beneficial effects of adenosine were abolished by pretreatment with A1 receptor antagonist. Conclusion: The data suggest that adenosine and Al receptor stimulation attenuate ischemic intestinal injury via decreasing oxidative stress, lowering neutrophil infiltration, and increasing reduced glutathione content. © 2007 The WJG Press. All rights reserved.

Dergi Adı World Journal of Gastroenterology
Dergi Cilt Bilgisi 13
Dergi Sayısı 4
Sayfalar 538 - 547
Yayın Yılı 2007
Eser Adı
[dc.title]
Pretreatment with adenosine and adenosine A1 receptor agonist protects againts intestinal ischemia-reperfusion injury in rat
Yazar
[dc.contributor.author]
Özaçmak, Veysel Haktan
Yazar
[dc.contributor.author]
Sayan, Hale
Yayın Yılı
[dc.date.issued]
2007
Yayıncı
[dc.publisher]
WJG Press
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Aim: To examine the effects of adenosine and A1 receptor activation on reperfusion-induced small intestinal injury. Methods: Rats were randomized into groups with sham operation, ischemia and reperfusion, and systemic treatments with either adenosine or 2-chloro-N6-cyclopentyladenosine, A1 receptor agonist or 8-cyclopentyl-1,3-dipropylxanthine, A1 receptor antagonist, plus adenosine before ischemia. Following reperfusion, contractions of ileum segments in response to KCI, carbachol and substance P were recorded. Tissue myeloperoxidase, malondialdehyde, and reduced glutathione levels were measured. Results: Ischemia significantly decreased both contraction and reduced glutathione level which were ameliorated by adenosine and agonist administration. Treatment also decreased neutrophil infiltration and membrane lipid peroxidation. Beneficial effects of adenosine were abolished by pretreatment with A1 receptor antagonist. Conclusion: The data suggest that adenosine and Al receptor stimulation attenuate ischemic intestinal injury via decreasing oxidative stress, lowering neutrophil infiltration, and increasing reduced glutathione content. © 2007 The WJG Press. All rights reserved.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Adenosine
Konu Başlıkları
[dc.subject]
Adenosine A1 receptor
Konu Başlıkları
[dc.subject]
Intestinal ischemia
Konu Başlıkları
[dc.subject]
Pharmacological preconditioning
Künye
[dc.identifier.citation]
Ozacmak, V. H., & Sayan, H. (2007). Pretreatment with adenosine and adenosine A1 receptor agonist protects against intestinal ischemia-reperfusion injury in rat. World journal of gastroenterology, 13(4), 538–547. https://doi.org/10.3748/wjg.v13.i4.538
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
1007-9327
İlk Sayfa Sayısı
[dc.identifier.startpage]
538
Son Sayfa Sayısı
[dc.identifier.endpage]
547
Dergi Adı
[dc.relation.journal]
World Journal of Gastroenterology
Dergi Sayısı
[dc.identifier.issue]
4
Dergi Cilt Bilgisi
[dc.identifier.volume]
13
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.3748/wjg.v13.i4.538
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/7156
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adenosine receptor glutathione reduced infiltration neutrophil decreased agonist injury intestinal reperfusion effects antagonist ischemia Beneficial abolished pretreatment peroxidation membrane Treatment administration ameliorated contraction Conclusion stimulation increasing reserved rights content lowering suggest stress oxidative decreasing ischemic
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