Ameliorative effects of Hesperidin on radiation induced brain injury in rats

Background: Extensive research has been focused on radiation induced brain injury. Animal and human studies have shown that flavonoids have remarkable toxicological profiles. This study aims to investigate the neuroprotective effects of hesperidin in an experimental radiation induced brain injury. Materials and Methods: 32 adult male Wistar-Albino rats were randomly divided into 4 groups (control, hesperidin, radiation, and radiation+hesperidin groups; 8 rats in each group). 200 mg/kg doses of hesperidin were administered to the animals in the hesperidin and radiation+ hesperidin groups, radiation and radiation+ hesperidin groups were exposed to a dose of 20 Gy cranium region. Tissue samples, and biochemical levels of tissue injury markers in four groups were compared. Results: In all measured parameters of oxidative stress, administration of hesperidin significantly demonstrated favorable effects. Both plasma and tissue levels of malondialdehyde and total antioxidant status significantly changed in favor of antioxidant activity. Histopathological evaluation of the tissues also demonstrated significant decrease in cellular degeneration and infiltration parameters after hesperidin administration. Conclusion: This Hesperidin demonstrated significant neuroprotection after radiation induced brain injury. Further studies with different experimental settings including neurological outcome are required to achieve conclusive results. © 2019 Novin Medical Radiation Institute. All rights reserved.

Yazar Kale A.
Pişkin Ö.
Baş Y.
Aydın B.G.
Can M.
Elmas Ö.
Büyükuysal Ç.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/4170
Tek Biçim Adres 10.18869/acadpub.ijrr.17.2.229
Konu Başlıkları Brain injury
Hesperidin
Neuroprotection
Radiation
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı International Journal of Radiation Research
Dergi Cilt Bilgisi 17
Dergi Sayısı 2
Sayfalar 229 - 236
Yayın Yılı 2019
Eser Adı
[dc.title]
Ameliorative effects of Hesperidin on radiation induced brain injury in rats
Yazar
[dc.contributor.author]
Kale A.
Yazar
[dc.contributor.author]
Pişkin Ö.
Yazar
[dc.contributor.author]
Baş Y.
Yazar
[dc.contributor.author]
Aydın B.G.
Yazar
[dc.contributor.author]
Can M.
Yazar
[dc.contributor.author]
Elmas Ö.
Yazar
[dc.contributor.author]
Büyükuysal Ç.
Yayın Yılı
[dc.date.issued]
2019
Yayıncı
[dc.publisher]
Novin Medical Radiation Institute
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Background: Extensive research has been focused on radiation induced brain injury. Animal and human studies have shown that flavonoids have remarkable toxicological profiles. This study aims to investigate the neuroprotective effects of hesperidin in an experimental radiation induced brain injury. Materials and Methods: 32 adult male Wistar-Albino rats were randomly divided into 4 groups (control, hesperidin, radiation, and radiation+hesperidin groups; 8 rats in each group). 200 mg/kg doses of hesperidin were administered to the animals in the hesperidin and radiation+ hesperidin groups, radiation and radiation+ hesperidin groups were exposed to a dose of 20 Gy cranium region. Tissue samples, and biochemical levels of tissue injury markers in four groups were compared. Results: In all measured parameters of oxidative stress, administration of hesperidin significantly demonstrated favorable effects. Both plasma and tissue levels of malondialdehyde and total antioxidant status significantly changed in favor of antioxidant activity. Histopathological evaluation of the tissues also demonstrated significant decrease in cellular degeneration and infiltration parameters after hesperidin administration. Conclusion: This Hesperidin demonstrated significant neuroprotection after radiation induced brain injury. Further studies with different experimental settings including neurological outcome are required to achieve conclusive results. © 2019 Novin Medical Radiation Institute. All rights reserved.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Brain injury
Konu Başlıkları
[dc.subject]
Hesperidin
Konu Başlıkları
[dc.subject]
Neuroprotection
Konu Başlıkları
[dc.subject]
Radiation
Künye
[dc.identifier.citation]
Kale, A., Pişkin, Ö., Baş, Y., Aydın, B., Çan, M., Elmas, Ö., & Buyukuysal, C. (2019). Ameliorative effects of Hesperidin on radiation induced brain injury in rats. Iranian Journal of Radiation Research, 17, 229-236.
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
2322-3243
İlk Sayfa Sayısı
[dc.identifier.startpage]
229
Son Sayfa Sayısı
[dc.identifier.endpage]
236
Dergi Adı
[dc.relation.journal]
International Journal of Radiation Research
Dergi Sayısı
[dc.identifier.issue]
2
Dergi Cilt Bilgisi
[dc.identifier.volume]
17
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.18869/acadpub.ijrr.17.2.229
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/4170
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
236
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
15 Temmuz 2024 00:09
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Tıklayınız
hesperidin groups radiation injury demonstrated induced radiation+ experimental effects significant antioxidant parameters tissue levels studies significantly administration Histopathological oxidative tissues evaluation activity stress decrease changed favorable status plasma malondialdehyde Background Further cellular achieve reserved rights
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