Analysis of glomerular filtration rate, serum cystatin C levels, and renal resistive index values in cirrhosis patients

Background: The aim of this study was to evaluate the relation of glomerular filtration rate (GFR) to serum cystatin C levels, renal resistive index (RRI), serum creatinine and creatinine clearance in patients with different stages of cirrhosis. Methods: The study sample was 25 cirrhotic patients (10 females and 15 males; mean age 57.3±2.04 years), 10 in the compensated stage without ascites and 15 in the decompensated stage with new-onset ascites. None had azotemia nor were on diuretic treatment. The control group comprised 25 healthy adults (11 female and 14 men; mean age 56.56±1.91 years). Serum cystatin C, RRI, serum creatinine and creatinine clearance were measured. GFR was determined by technetium99m- diethylene triamine pentaacetic acid renal scintigraphy. Results: Cirrhosis cases had lower mean scintigraphic GFR than controls (64.5±4.03 vs. 87.96±4.16 mL/min, p<0.05). Serum cystatin C and RRI were significantly higher in the cirrhotic group compared to controls (1.16±0.09 mg/L and 0.68±0.01 vs. 0.86±0.03 mg/L and 0.64±0.01, respectively; p<0.05). Subgroup comparative analysis showed that only two parameters, scintigraphic GFR and serum cystatin C, were significantly different between compensated and decompensated cirrhotics (75.62±4.9 mL/min and 0.89±0.07 mg/L vs. 57.23±5.14 mL/min and 1.34±0.13mg/L, respectively; p<0.05). Scintigraphic GFR showed significant correlation with cystatin C, but not with serum creatinine or creatinine clearance (r=-0.877, p<0.05) in decompensated patients. No correlation was observed between scintigraphic GFR and RRI or between serum cystatin C and RRI in all subjects. A receiver operator characteristics curve showed that cystatin C at a cutoff value of 1.01 mg/L can significantly differentiate patients with GFR <70 mL/min with 80% sensitivity and 80% specificity. Conclusions: Serum cystatin C, but not serum creatinine or RRI measurement, correlates with GFR in each stage of liver failure and has a significant diagnostic advantage in detecting lower GFR in such cases. © 2007 by Walter de Gruyter.

Dergi Adı Clinical Chemistry and Laboratory Medicine
Dergi Cilt Bilgisi 45
Dergi Sayısı 7
Sayfalar 890 - 894
Yayın Yılı 2007
Eser Adı
[dc.title]
Analysis of glomerular filtration rate, serum cystatin C levels, and renal resistive index values in cirrhosis patients
Yazar
[dc.contributor.author]
Üstündağ, Yücel
Yazar
[dc.contributor.author]
Samsar, Ufuk
Yazar
[dc.contributor.author]
Açıkgöz, Şereften
Yazar
[dc.contributor.author]
Çabuk, Mehmet
Yazar
[dc.contributor.author]
Kıran, Sibel
Yazar
[dc.contributor.author]
Külah, Eyüp
Yazar
[dc.contributor.author]
Aydemir, Selim
Yayın Yılı
[dc.date.issued]
2007
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Background: The aim of this study was to evaluate the relation of glomerular filtration rate (GFR) to serum cystatin C levels, renal resistive index (RRI), serum creatinine and creatinine clearance in patients with different stages of cirrhosis. Methods: The study sample was 25 cirrhotic patients (10 females and 15 males; mean age 57.3±2.04 years), 10 in the compensated stage without ascites and 15 in the decompensated stage with new-onset ascites. None had azotemia nor were on diuretic treatment. The control group comprised 25 healthy adults (11 female and 14 men; mean age 56.56±1.91 years). Serum cystatin C, RRI, serum creatinine and creatinine clearance were measured. GFR was determined by technetium99m- diethylene triamine pentaacetic acid renal scintigraphy. Results: Cirrhosis cases had lower mean scintigraphic GFR than controls (64.5±4.03 vs. 87.96±4.16 mL/min, p<0.05). Serum cystatin C and RRI were significantly higher in the cirrhotic group compared to controls (1.16±0.09 mg/L and 0.68±0.01 vs. 0.86±0.03 mg/L and 0.64±0.01, respectively; p<0.05). Subgroup comparative analysis showed that only two parameters, scintigraphic GFR and serum cystatin C, were significantly different between compensated and decompensated cirrhotics (75.62±4.9 mL/min and 0.89±0.07 mg/L vs. 57.23±5.14 mL/min and 1.34±0.13mg/L, respectively; p<0.05). Scintigraphic GFR showed significant correlation with cystatin C, but not with serum creatinine or creatinine clearance (r=-0.877, p<0.05) in decompensated patients. No correlation was observed between scintigraphic GFR and RRI or between serum cystatin C and RRI in all subjects. A receiver operator characteristics curve showed that cystatin C at a cutoff value of 1.01 mg/L can significantly differentiate patients with GFR <70 mL/min with 80% sensitivity and 80% specificity. Conclusions: Serum cystatin C, but not serum creatinine or RRI measurement, correlates with GFR in each stage of liver failure and has a significant diagnostic advantage in detecting lower GFR in such cases. © 2007 by Walter de Gruyter.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Ascites
Konu Başlıkları
[dc.subject]
Glomerular filtration rate
Konu Başlıkları
[dc.subject]
Liver cirrhosis stage
Konu Başlıkları
[dc.subject]
Renal resistive index
Konu Başlıkları
[dc.subject]
Serum cystatin C
Künye
[dc.identifier.citation]
Ustundag, Y., Samsar, U., Acikgoz, S., Cabuk, M., Kiran, S., Kulah, E. ve Aydemir, S. (2007). Analysis of glomerular filtration rate, serum cystatin C levels, and renal resistive index values in cirrhosis patients. Clinical Chemistry and Laboratory Medicine (CCLM), 45(7), 890-894. doi:10.1515/CCLM.2007.130
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
1434-6621
İlk Sayfa Sayısı
[dc.identifier.startpage]
890
Son Sayfa Sayısı
[dc.identifier.endpage]
894
Dergi Adı
[dc.relation.journal]
Clinical Chemistry and Laboratory Medicine
Dergi Sayısı
[dc.identifier.issue]
7
Dergi Cilt Bilgisi
[dc.identifier.volume]
45
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1515/CCLM.2007.130
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/4266
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
61
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
09 Şubat 2024 18:12
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Tıklayınız
cystatin creatinine patients mL/min between decompensated clearance scintigraphic showed significantly correlation respectively significant ascites compensated cirrhotic different controls years) comparative analysis Scintigraphic 13mg/L parameters cirrhotics advantage correlates failure diagnostic detecting Conclusions Walter Gruyter measurement specificity
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