Erdosteine improves oxidative damage in a rat model of renal ischemia-reperfusion injury

The aim of the present study was to determine the effects of erdosteine, a new antioxidant and anti-inflammatory agent, on lipid peroxidation, neutrophil infiltration, and antioxidant enzyme activities in a rat model of renal ischemia-reperfusion (I/R) injury. Twenty-eight rats were divided into three groups: sham operation, I/R, and I/R plus erdosteine groups. After the experimental procedure, rats were sacrificed and kidneys were removed and prepared for malondialdehyde (MDA) levels, myeloperoxidase (MPO), xanthine oxidase (XO), catalase (CAT) and superoxide dismutase (SOD) activities. MDA level, MPO and XO activities were significantly increased in the I/R group. On the other hand, SOD and CAT activities were found to be decreased in the I/R group compared to the sham group. Pretreatment with erdosteine significantly diminished tissue MDA level, MPO and XO activities. Our data support a role for erdosteine in attenuation in renal damage after I/R injury of the kidney, in part at least by inhibition of neutrophil sequestration and XO activity. Copyright © 2004 S. Karger AG, Basel.

Eser Adı
[dc.title]
Erdosteine improves oxidative damage in a rat model of renal ischemia-reperfusion injury
Yazar
[dc.contributor.author]
Gürel, Ahmet
Yazar
[dc.contributor.author]
Armutcu, Ferah
Yazar
[dc.contributor.author]
Cihan, Alper
Yazar
[dc.contributor.author]
Numanoğlu, Kemal Varın
Yazar
[dc.contributor.author]
Unalacak, Murat
Yayın Yılı
[dc.date.issued]
2004
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
The aim of the present study was to determine the effects of erdosteine, a new antioxidant and anti-inflammatory agent, on lipid peroxidation, neutrophil infiltration, and antioxidant enzyme activities in a rat model of renal ischemia-reperfusion (I/R) injury. Twenty-eight rats were divided into three groups: sham operation, I/R, and I/R plus erdosteine groups. After the experimental procedure, rats were sacrificed and kidneys were removed and prepared for malondialdehyde (MDA) levels, myeloperoxidase (MPO), xanthine oxidase (XO), catalase (CAT) and superoxide dismutase (SOD) activities. MDA level, MPO and XO activities were significantly increased in the I/R group. On the other hand, SOD and CAT activities were found to be decreased in the I/R group compared to the sham group. Pretreatment with erdosteine significantly diminished tissue MDA level, MPO and XO activities. Our data support a role for erdosteine in attenuation in renal damage after I/R injury of the kidney, in part at least by inhibition of neutrophil sequestration and XO activity. Copyright © 2004 S. Karger AG, Basel.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Antioxidant enzymes
Konu Başlıkları
[dc.subject]
Erdosteine
Konu Başlıkları
[dc.subject]
Lipid peroxidation
Konu Başlıkları
[dc.subject]
Myeloperoxidase
Konu Başlıkları
[dc.subject]
Renal ischemia-reperfusion injury
Konu Başlıkları
[dc.subject]
Xanthine oxidase
Künye
[dc.identifier.citation]
Gurel, A., Armutcu, F., Cihan, A., Numanoglu, K. V. ve Unalacak, M. (2004). Erdosteine Improves Oxidative Damage in a Rat Model of Renal Ischemia-Reperfusion Injury. European Surgical Research, 36(4), 206–209. doi:10.1159/000078854
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0014312X
İlk Sayfa Sayısı
[dc.identifier.startpage]
206
Son Sayfa Sayısı
[dc.identifier.endpage]
209
Dergi Adı
[dc.relation.journal]
European Surgical Research
Dergi Sayısı
[dc.identifier.issue]
4
Dergi Cilt Bilgisi
[dc.identifier.volume]
36
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1159/000078854
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/5660
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activities erdosteine groups significantly injury neutrophil antioxidant compared decreased increased Karger Pretreatment tissue diminished attenuation kidney damage inhibition sequestration activity support Copyright levels Twenty-eight ischemia-reperfusion enzyme infiltration peroxidation anti-inflammatory effects determine present divided dismutase superoxide
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