Beneficial effects of melatonin on reperfusion injury in rat sciatic nerve

Studies have shown that ischemia-reperfusion (I/R) produces free radicals leading to lipid peroxidation and to damage of the nervous tissue. Melatonin, a main secretory product of the pineal gland, has free radical scavenging and antioxidant properties and has been shown to diminish I/R injury in many tissues. There are a limited number of studies related to the effects of melatonin on I/R injury in the peripheral nervous system. Therefore, in the present study, the protective effect of melatonin was investigated in rats subjected to 2 hr of sciatic nerve ischemia followed by 3 hr of reperfusion. Following reperfusion, nerve tissue samples were collected for quantitative assesment of malondialdehyde (MDA). an oxidative stress marker, and superoxide dismutase (SOD), a principal antioxidant enzyme. Samples were further evaluated at electron microscopic level to examine the neuropathological changes. I/R elevated the concentration of MDA significantly while there was a reduction at SOD levels. Melatonin treatment reversed the I/R-induced increase and decrease in MDA and SOD levels, respectively. Furthermore, melatonin salvaged the nerve fibers from ischemic degeneration. Histopathologic findings in the samples of melatonin-treated animals indicated less edema and less damage to the myelin sheaths and axons than those observed in the control samples. Our results suggest that administration of melatonin protects the sciatic nerve from I/R injury, which may be attributed to its antioxidant property.

Dergi Adı Journal of Pineal Research
Dergi Cilt Bilgisi 37
Dergi Sayısı 3
Sayfalar 143 - 148
Yayın Yılı 2004
Eser Adı
[dc.title]
Beneficial effects of melatonin on reperfusion injury in rat sciatic nerve
Yazar
[dc.contributor.author]
Sayan, Hale
Yazar
[dc.contributor.author]
Özaçmak, Veysel Haktan
Yazar
[dc.contributor.author]
Özen, Oğuz Aslan
Yazar
[dc.contributor.author]
Coşkun, Ömer
Yazar
[dc.contributor.author]
Arslan, S. Oktay
Yazar
[dc.contributor.author]
Sezen, S. Cem
Yazar
[dc.contributor.author]
Aktaş, R. Gülhan
Yayın Yılı
[dc.date.issued]
2004
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Studies have shown that ischemia-reperfusion (I/R) produces free radicals leading to lipid peroxidation and to damage of the nervous tissue. Melatonin, a main secretory product of the pineal gland, has free radical scavenging and antioxidant properties and has been shown to diminish I/R injury in many tissues. There are a limited number of studies related to the effects of melatonin on I/R injury in the peripheral nervous system. Therefore, in the present study, the protective effect of melatonin was investigated in rats subjected to 2 hr of sciatic nerve ischemia followed by 3 hr of reperfusion. Following reperfusion, nerve tissue samples were collected for quantitative assesment of malondialdehyde (MDA). an oxidative stress marker, and superoxide dismutase (SOD), a principal antioxidant enzyme. Samples were further evaluated at electron microscopic level to examine the neuropathological changes. I/R elevated the concentration of MDA significantly while there was a reduction at SOD levels. Melatonin treatment reversed the I/R-induced increase and decrease in MDA and SOD levels, respectively. Furthermore, melatonin salvaged the nerve fibers from ischemic degeneration. Histopathologic findings in the samples of melatonin-treated animals indicated less edema and less damage to the myelin sheaths and axons than those observed in the control samples. Our results suggest that administration of melatonin protects the sciatic nerve from I/R injury, which may be attributed to its antioxidant property.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Free radical scavenger
Konu Başlıkları
[dc.subject]
Malondialdehyde
Konu Başlıkları
[dc.subject]
Melatonin
Konu Başlıkları
[dc.subject]
Oxidative stress
Konu Başlıkları
[dc.subject]
Rat
Konu Başlıkları
[dc.subject]
Reperfusion injury
Konu Başlıkları
[dc.subject]
Sciatic nerve
Konu Başlıkları
[dc.subject]
Superoxide dismutase
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0742-3098
İlk Sayfa Sayısı
[dc.identifier.startpage]
143
Son Sayfa Sayısı
[dc.identifier.endpage]
148
Dergi Adı
[dc.relation.journal]
Journal of Pineal Research
Dergi Sayısı
[dc.identifier.issue]
3
Dergi Cilt Bilgisi
[dc.identifier.volume]
37
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1111/j.1600-079X.2004.00145.x
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/4482
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
71
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
09 Şubat 2024 12:06
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Tıklayınız
melatonin injury samples antioxidant sciatic reperfusion levels Melatonin nervous damage tissue treatment reversed I/R-induced reduction Studies significantly decrease concentration elevated changes neuropathological examine microscopic electron evaluated further increase melatonin-treated respectively property attributed protects administration suggest
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