Role of angiotensin and endothelin in testicular ischemia reperfusion injury

Objectives: To determine whether angiotensin and endothelin have any role in testicular ischemia reperfusion injury by investigating the effects of the angiotensin converting enzyme inhibitor enalapril, selective non-peptide angiotensin-II type I blocker losartan and dual endothelin receptor blocker bosentan. Methods: Rats were anesthetized with thiopental sodium (50mg/kg i.p.) before the operation. The left testicular artery and vein of rats were occluded for 1h; before the bilateral orchiectomy, the organ was allowed to reperfuse for 3h or 24h. Enalapril (20mg/kg i.p.), losartan (30mg/kg i.p.), bosentan (10mg/kg i.p.) or vehicle (saline) were given 30min before reperfusion. Malondialdehyde level was measured in testicular tissue after 3h of reperfusion. Histological examination was carried out after 24h of reperfusion. Results: Ischemia reperfusion caused a significant increase in malondialdehyde level of ipsilateral testis, and histopathological injury in both ipsilateral and contralateral testes. Enalapril, losartan and bosentan treatments prevented the ischemia reperfusion-induced augmentation in malondialdehyde levels. Only bosentan treatment ameloriated ischemia reperfusion-induced histopathological alterations. Conclusions: Endothelin might play a more important role in pathogenesis of testicular ischemia reperfusion injury when compared with angiotensin. © 2011 The Japanese Urological Association.

Yazar Türkili, Burak
Kurçer, Zehra
Dengiz-Özbakış, Günnur
Kandemir-Onak, Nilüfer
Mungan, Görkem
Özaçmak, Veysel Haktan
Banoğlu, Zekeriya Nur
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/7442
Tek Biçim Adres 10.1111/j.1442-2042.2011.02924.x
Konu Başlıkları Bosentan
Enalapril
Ischemia-reperfusion injury
Losartan
Testis
Koleksiyonlar Fakülteler
Tıp Fakültesi
Dahili Tıp Bilimleri
Makale Koleksiyonu (Dahili Tıp Bilimleri)
Fakülteler
Tıp Fakültesi
Temel Tıp Bilimleri
Makale Koleksiyonu (Temel Tıp Bilimleri)
Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı International Journal of Urology
Dergi Cilt Bilgisi 19
Dergi Sayısı 3
Sayfalar 257 - 263
Yayın Yılı 2012
Eser Adı
[dc.title]
Role of angiotensin and endothelin in testicular ischemia reperfusion injury
Yazar
[dc.contributor.author]
Türkili, Burak
Yazar
[dc.contributor.author]
Kurçer, Zehra
Yazar
[dc.contributor.author]
Dengiz-Özbakış, Günnur
Yazar
[dc.contributor.author]
Kandemir-Onak, Nilüfer
Yazar
[dc.contributor.author]
Mungan, Görkem
Yazar
[dc.contributor.author]
Özaçmak, Veysel Haktan
Yazar
[dc.contributor.author]
Banoğlu, Zekeriya Nur
Yayın Yılı
[dc.date.issued]
2012
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Objectives: To determine whether angiotensin and endothelin have any role in testicular ischemia reperfusion injury by investigating the effects of the angiotensin converting enzyme inhibitor enalapril, selective non-peptide angiotensin-II type I blocker losartan and dual endothelin receptor blocker bosentan. Methods: Rats were anesthetized with thiopental sodium (50mg/kg i.p.) before the operation. The left testicular artery and vein of rats were occluded for 1h; before the bilateral orchiectomy, the organ was allowed to reperfuse for 3h or 24h. Enalapril (20mg/kg i.p.), losartan (30mg/kg i.p.), bosentan (10mg/kg i.p.) or vehicle (saline) were given 30min before reperfusion. Malondialdehyde level was measured in testicular tissue after 3h of reperfusion. Histological examination was carried out after 24h of reperfusion. Results: Ischemia reperfusion caused a significant increase in malondialdehyde level of ipsilateral testis, and histopathological injury in both ipsilateral and contralateral testes. Enalapril, losartan and bosentan treatments prevented the ischemia reperfusion-induced augmentation in malondialdehyde levels. Only bosentan treatment ameloriated ischemia reperfusion-induced histopathological alterations. Conclusions: Endothelin might play a more important role in pathogenesis of testicular ischemia reperfusion injury when compared with angiotensin. © 2011 The Japanese Urological Association.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Bosentan
Konu Başlıkları
[dc.subject]
Enalapril
Konu Başlıkları
[dc.subject]
Ischemia-reperfusion injury
Konu Başlıkları
[dc.subject]
Losartan
Konu Başlıkları
[dc.subject]
Testis
Künye
[dc.identifier.citation]
Turkili, B., Kurcer, Z., Dengiz, G. O., Kandemir, N. O., Mungan, G., Ozacmak, V. H., & Banoglu, Z. N.. (2012). Role of angiotensin and endothelin in testicular ischemia reperfusion injury. International Journal of Urology. International Journal of Urology. http://doi.org/10.1111/j.1442-2042.2011.02924.x
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0919-8172
İlk Sayfa Sayısı
[dc.identifier.startpage]
257
Son Sayfa Sayısı
[dc.identifier.endpage]
263
Dergi Adı
[dc.relation.journal]
International Journal of Urology
Dergi Sayısı
[dc.identifier.issue]
3
Dergi Cilt Bilgisi
[dc.identifier.volume]
19
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1111/j.1442-2042.2011.02924.x
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/7442
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33
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09 Şubat 2024 07:36
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reperfusion bosentan testicular ischemia before losartan angiotensin injury malondialdehyde ipsilateral histopathological blocker reperfusion-induced Enalapril endothelin testis tissue Histological caused examination carried significant increase Ischemia Results Objectives Association Urological Japanese compared pathogenesis important contralateral Endothelin Conclusions
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