Impact of synaptic noise and conductance state on spontaneous cortical firing

Cortical neurons in-vivo operate in a continuum of overall conductance states, depending on the average level of background synaptic input throughout the dendritic tree. We compare how variability, or fluctuations, in this input affects the statistics of the resulting 'spontaneous' or 'background' firing activity, between two extremes of the mean input corresponding to a low-conductance (LC) and a high-conductance (HC) state. In the HC state, we show that both firing rate and regularity increase with increasing variability. In the LC state, firing rate also increases with input variability, but in contrast to the HC state, firing regularity first decreases and then increases with an increase in the variability. At high levels of input variability, firing regularity in both states converge to similar values. © 2007 Lippincott Williams & Wilkins, Inc.

Dergi Adı NeuroReport
Dergi Cilt Bilgisi 18
Dergi Sayısı 13
Sayfalar 1371 - 1374
Yayın Yılı 2007
Eser Adı
[dc.title]
Impact of synaptic noise and conductance state on spontaneous cortical firing
Yazar
[dc.contributor.author]
Özer, Mahmut
Yazar
[dc.contributor.author]
Graham, Lyle J.
Yazar
[dc.contributor.author]
Erkaymaz, Okan
Yazar
[dc.contributor.author]
Uzuntarla, Muhammet
Yayın Yılı
[dc.date.issued]
2007
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Cortical neurons in-vivo operate in a continuum of overall conductance states, depending on the average level of background synaptic input throughout the dendritic tree. We compare how variability, or fluctuations, in this input affects the statistics of the resulting 'spontaneous' or 'background' firing activity, between two extremes of the mean input corresponding to a low-conductance (LC) and a high-conductance (HC) state. In the HC state, we show that both firing rate and regularity increase with increasing variability. In the LC state, firing rate also increases with input variability, but in contrast to the HC state, firing regularity first decreases and then increases with an increase in the variability. At high levels of input variability, firing regularity in both states converge to similar values. © 2007 Lippincott Williams & Wilkins, Inc.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Conductance states
Konu Başlıkları
[dc.subject]
Cortical neuron
Konu Başlıkları
[dc.subject]
Spike regularity
Konu Başlıkları
[dc.subject]
Synaptic background activity
Künye
[dc.identifier.citation]
Ozer, M., Graham, L. J., Erkaymaz, O. ve Uzuntarla, M. (2007). Impact of synaptic noise and conductance state on spontaneous cortical firing. NeuroReport, 18(13). https://journals.lww.com/neuroreport/Fulltext/2007/08270/Impact_of_synaptic_noise_and_conductance_state_on.14.aspx adresinden erişildi.
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0959-4965
İlk Sayfa Sayısı
[dc.identifier.startpage]
1371
Son Sayfa Sayısı
[dc.identifier.endpage]
1374
Dergi Adı
[dc.relation.journal]
NeuroReport
Dergi Sayısı
[dc.identifier.issue]
13
Dergi Cilt Bilgisi
[dc.identifier.volume]
18
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1097/WNR.0b013e328277ef8a
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/6167
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
10
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
09 Şubat 2024 23:01
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variability firing regularity increase increases background states levels increasing Wilkins Williams Lippincott values contrast similar decreases converge Cortical compare in-vivo operate continuum overall conductance depending average synaptic throughout dendritic high-conductance low-conductance neurons corresponding extremes between
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