Activation kinetics of T-type calcium channel by a path probability approximation

We previously formulated dynamics of ion channel gates by the path probability method. In this study, we apply that theoretical approach to derive the activation rate kinetics of T-type calcium channel in thalamic relay neurons. We derive explicit expressions of the forward and backward rate constants and show that the proposed rate constants accurately capture form of the empirical time constant, and that they also provide its saturation to a constant value at depolarized membrane potentials. We also compare our derivations with linear and nonlinear thermodynamic models of rate kinetics obtained from the same calcium channel, and show that it is possible to capture saturation of the time constant for the depolarized membrane potentials by the only proposed rate constants. © 2004 Lippincott Williams & Wilkins.

Eser Adı
[dc.title]
Activation kinetics of T-type calcium channel by a path probability approximation
Yazar
[dc.contributor.author]
Özer, Mahmut
Yayın Yılı
[dc.date.issued]
2004
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
We previously formulated dynamics of ion channel gates by the path probability method. In this study, we apply that theoretical approach to derive the activation rate kinetics of T-type calcium channel in thalamic relay neurons. We derive explicit expressions of the forward and backward rate constants and show that the proposed rate constants accurately capture form of the empirical time constant, and that they also provide its saturation to a constant value at depolarized membrane potentials. We also compare our derivations with linear and nonlinear thermodynamic models of rate kinetics obtained from the same calcium channel, and show that it is possible to capture saturation of the time constant for the depolarized membrane potentials by the only proposed rate constants. © 2004 Lippincott Williams & Wilkins.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Activation gate
Konu Başlıkları
[dc.subject]
Ion channel
Konu Başlıkları
[dc.subject]
Path probability model
Konu Başlıkları
[dc.subject]
T-type calcium channel
Konu Başlıkları
[dc.subject]
Thermodynamic model
Künye
[dc.identifier.citation]
Ozer M. (2004). Activation kinetics of T-type calcium channel by a path probability approximation. Neuroreport, 15(9), 1451–1455. https://doi.org/10.1097/01.wnr.0000128429.81961.0a
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0959-4965
İlk Sayfa Sayısı
[dc.identifier.startpage]
1451
Son Sayfa Sayısı
[dc.identifier.endpage]
1455
Dergi Adı
[dc.relation.journal]
NeuroReport
Dergi Sayısı
[dc.identifier.issue]
9
Dergi Cilt Bilgisi
[dc.identifier.volume]
15
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1097/01.wnr.0000128429.81961.0a
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/4121
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channel constant constants kinetics calcium capture saturation depolarized membrane potentials derive proposed approach obtained dynamics formulated compare derivations linear nonlinear thermodynamic models possible Lippincott Williams Wilkins activation theoretical T-type thalamic neurons explicit expressions forward backward
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