Synthesis of microbial elastomers based on soybean oily acids. Biocompatibility studies

Biocompatibility studies of the autoxidized and unoxidized unsaturated medium-long chain length (m-lcl) co-poly-3-hydroxyalkanoates (m-lclPHAs) derived from soya oily acids have been reported. Pseudomonas oleovorans was grown on a series of mixtures of octanoic acid (OA) and soya oily acids (Sy) with weight ratios of 20:80, 28:72 and 50:50 in order to obtain unsaturated m-lcl copolyesters coded PHO-Sy-2080, PHO-Sy-2872 and PHO-Sy-5050, respectively. The PHA films were obtained by solvent cast from CHCl3. They were all originally sticky and waxy except PHO-Sy-5050. Autoxidation of the unsaturated copolyester films was carried out on exposure to air at room temperature in order to obtain crosslinked polymers. They became a highly flexible elastomer after being autoxidized (about 40 days of autoxidation). The in vivo tissue reactions of the autoxidized PHAs were evaluated by subcutaneous implantation in rats. The rats appeared to be healthy throughout the implantation period. No symptom such as necrosis, abscess or tumorigenesis was observed in the vicinity of the implants. Retrieved materials varied in their physical appearance after 6 weeks of implantation. In vivo biocompatibility studies of the medical applications indicated that the microbial copolyesters obtained were all biocompatible and especially the PHOSy series of copolyesters had the highest biocompatibility among them. © 2009 IOP Publishing Ltd.

Dergi Adı Biomedical Materials
Dergi Cilt Bilgisi 4
Dergi Sayısı 3
Sayfalar -
Yayın Yılı 2009
Eser Adı
[dc.title]
Synthesis of microbial elastomers based on soybean oily acids. Biocompatibility studies
Yazar
[dc.contributor.author]
Hazer, Derya Burcu
Yazar
[dc.contributor.author]
Hazer, Baki
Yazar
[dc.contributor.author]
Kaymaz, Figen
Yayın Yılı
[dc.date.issued]
2009
Yayıncı
[dc.publisher]
Institute of Physics Publishing
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Biocompatibility studies of the autoxidized and unoxidized unsaturated medium-long chain length (m-lcl) co-poly-3-hydroxyalkanoates (m-lclPHAs) derived from soya oily acids have been reported. Pseudomonas oleovorans was grown on a series of mixtures of octanoic acid (OA) and soya oily acids (Sy) with weight ratios of 20:80, 28:72 and 50:50 in order to obtain unsaturated m-lcl copolyesters coded PHO-Sy-2080, PHO-Sy-2872 and PHO-Sy-5050, respectively. The PHA films were obtained by solvent cast from CHCl3. They were all originally sticky and waxy except PHO-Sy-5050. Autoxidation of the unsaturated copolyester films was carried out on exposure to air at room temperature in order to obtain crosslinked polymers. They became a highly flexible elastomer after being autoxidized (about 40 days of autoxidation). The in vivo tissue reactions of the autoxidized PHAs were evaluated by subcutaneous implantation in rats. The rats appeared to be healthy throughout the implantation period. No symptom such as necrosis, abscess or tumorigenesis was observed in the vicinity of the implants. Retrieved materials varied in their physical appearance after 6 weeks of implantation. In vivo biocompatibility studies of the medical applications indicated that the microbial copolyesters obtained were all biocompatible and especially the PHOSy series of copolyesters had the highest biocompatibility among them. © 2009 IOP Publishing Ltd.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Künye
[dc.identifier.citation]
Hazer, D. B., Hazer, B. ve Kaymaz, F. (2009). Synthesis of microbial elastomers based on soybean oily acids. Biocompatibility studies. Biomedical Materials, 4(3), 035011. doi:10.1088/1748-6041/4/3/035011
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
1748-6041
Dergi Adı
[dc.relation.journal]
Biomedical Materials
Dergi Sayısı
[dc.identifier.issue]
3
Dergi Cilt Bilgisi
[dc.identifier.volume]
4
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1088/1748-6041/4/3/035011
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/7769
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implantation copolyesters autoxidized unsaturated obtain PHO-Sy-5050 obtained series studies biocompatibility symptom period throughout healthy appeared abscess Publishing subcutaneous evaluated reactions tissue autoxidation) necrosis appearance physical varied materials microbial biocompatible especially Retrieved highest implants vicinity observed
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