Erythropoietin stimulates wound healing and angiogenesis in mice

Erythropoietin exerts hematopoietic effects by stimulating proliferation of early erythroid precursors. Nonhematopoietic effects of erythropoietin have also been shown. It may act as a new angiogenic factor in wound healing. This study aimed to investigate the effect of systemic administration of recombinant human erythropoietin on wound healing in mice. Dorsal incisional wounds were performed in mice, which were then divided into two groups; a group treated for 7 days with recombinant human erythropoietin, and a control group. Sacrificing animals on day 7, the wound tissues were collected for analysis of wound breaking strength, malondialdehyde, a marker of lipid peroxidation, hydroxyproline, an index of reparative collagen deposition, reduced glutathione levels, and for histological evaluation. The immunohistochemical determination of vascular endothelial growth factor (VEGF) which is believed to be the most prevalent angiogenic factor throughout the skin repair process, was also studied. The treatment significantly increased wound breaking strength by decreasing malondialdehyde and increasing hydroxyproline levels on day 7 after wounding. No statistically meaningful change was observed in reduced glutathione content. VEGF was immunostained significantly more on wound tissue of treated animals compared to the control group. Recombinant human erythropoietin treatment may be effective in wound healing due to inhibition of lipid peroxidation, deposition of collagen, and VEGF expression in wound area. Copyright © Taylor & Francis Group, LLC.

Dergi Adı Journal of Investigative Surgery
Dergi Cilt Bilgisi 19
Dergi Sayısı 3
Sayfalar 163 - 173
Yayın Yılı 2006
Eser Adı
[dc.title]
Erythropoietin stimulates wound healing and angiogenesis in mice
Yazar
[dc.contributor.author]
Sayan, Hale
Yazar
[dc.contributor.author]
Özaçmak, Veysel Haktan
Yazar
[dc.contributor.author]
Güven, Aysel
Yazar
[dc.contributor.author]
Aktaş, R. Gülhan
Yazar
[dc.contributor.author]
Özaçmak, I. Diler
Yayın Yılı
[dc.date.issued]
2006
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Erythropoietin exerts hematopoietic effects by stimulating proliferation of early erythroid precursors. Nonhematopoietic effects of erythropoietin have also been shown. It may act as a new angiogenic factor in wound healing. This study aimed to investigate the effect of systemic administration of recombinant human erythropoietin on wound healing in mice. Dorsal incisional wounds were performed in mice, which were then divided into two groups; a group treated for 7 days with recombinant human erythropoietin, and a control group. Sacrificing animals on day 7, the wound tissues were collected for analysis of wound breaking strength, malondialdehyde, a marker of lipid peroxidation, hydroxyproline, an index of reparative collagen deposition, reduced glutathione levels, and for histological evaluation. The immunohistochemical determination of vascular endothelial growth factor (VEGF) which is believed to be the most prevalent angiogenic factor throughout the skin repair process, was also studied. The treatment significantly increased wound breaking strength by decreasing malondialdehyde and increasing hydroxyproline levels on day 7 after wounding. No statistically meaningful change was observed in reduced glutathione content. VEGF was immunostained significantly more on wound tissue of treated animals compared to the control group. Recombinant human erythropoietin treatment may be effective in wound healing due to inhibition of lipid peroxidation, deposition of collagen, and VEGF expression in wound area. Copyright © Taylor & Francis Group, LLC.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Breaking strength
Konu Başlıkları
[dc.subject]
Erythropoietin
Konu Başlıkları
[dc.subject]
Lipid peroxidation
Konu Başlıkları
[dc.subject]
VEGF
Konu Başlıkları
[dc.subject]
Wound healing
Künye
[dc.identifier.citation]
Hale Sayan, V. Haktan Ozacmak, Aysel Guven, R. Gulhan Aktas & I. Diler Ozacmak (2006) Erythropoietin Stimulates Wound Healing and Angiogenesis in Mice, Journal of Investigative Surgery, 19:3, 163-173, DOI: 10.1080/08941930600674694
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0894-1939
İlk Sayfa Sayısı
[dc.identifier.startpage]
163
Son Sayfa Sayısı
[dc.identifier.endpage]
173
Dergi Adı
[dc.relation.journal]
Journal of Investigative Surgery
Dergi Sayısı
[dc.identifier.issue]
3
Dergi Cilt Bilgisi
[dc.identifier.volume]
19
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1080/08941930600674694
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/5672
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Görüntülenme
30
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
09 Şubat 2024 23:58
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Tıklayınız
erythropoietin factor healing breaking control animals effects levels recombinant treatment significantly glutathione reduced strength malondialdehyde deposition collagen treated angiogenic peroxidation hydroxyproline studied (VEGF) process throughout prevalent believed repair statistically increased Recombinant Francis Taylor Copyright expression
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