Evaluation of the protective effect of agmatine against cisplatin nephrotoxicity with 99mTc-DMSA renal scintigraphy and cystatin-C

Background: The aim of the current study was to investigate whether agmatine (AGM) has a protective effect against cisplatin-induced nephrotoxicity. Materials and methods: Thirty-two rats were randomly divided into four groups: (1) Saline (control); (2) Cisplatin (CDDP; 7.5 mg/kg intraperitoneally); (3) Agmatine (AGM; 10 mg/kg intraperitoneally); (4) Cisplatin plus agmatine (CDDP + AGM). Agmatine was given before and two consecutive days after cisplatin injection. All the animals underwent renal scintigraphy with 99mTc-DMSA. The levels of serum creatinine, cystatin C, and blood urea nitrogen (BUN) were measured in addition to examination of the tissue samples with light microscopy. Acute renal injury was assessed with biochemical analyses, scintigraphic imaging, and histopathological evaluation. Results: In the cisplatin group, the levels of BUN, creatinine, and cystatin C were significantly higher than that of the controls. Histopathological examination showed remarkable damage of tubular and glomerular structures. Additionally, cisplatin caused markedly decreased renal 99mTc-DMSA uptake. AGM administration improved renal functions. Serum creatinine, BUN, and cystatin C levels had a tendency to normalize and, scintigraphic and histopathological findings showed significantly less evidence of renal toxicity than those observed in animals receiving cisplatin alone. Conclusions: Our data indicate that AGM has a protective effect against cisplatin-induced nephrotoxicity. Therefore, it may improve the therapeutic index of cisplatin. In addition, the early renal damage induced by cisplatin and protective effects of AGM against cisplatin nephrotoxicity was accurately demonstrated with 99mTc-DMSA renal scintigraphy. © 2016 Informa UK Limited, trading as Taylor & Francis Group.

Yazar Salihoglu Y.S.
Elri T.
Gulle K.
Can M.
Aras M.
Ozacmak H.S.
Cabuk M.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/5783
Tek Biçim Adres 10.1080/0886022X.2016.1227919
Konu Başlıkları 99mTc-DMSA
Agmatine
cisplatin
cystatin C
nephrotoxicity
scintigraphy
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı Renal Failure
Dergi Cilt Bilgisi 38
Dergi Sayısı 9
Sayfalar 1496 - 1502
Yayın Yılı 2016
Eser Adı
[dc.title]
Evaluation of the protective effect of agmatine against cisplatin nephrotoxicity with 99mTc-DMSA renal scintigraphy and cystatin-C
Yazar
[dc.contributor.author]
Salihoglu Y.S.
Yazar
[dc.contributor.author]
Elri T.
Yazar
[dc.contributor.author]
Gulle K.
Yazar
[dc.contributor.author]
Can M.
Yazar
[dc.contributor.author]
Aras M.
Yazar
[dc.contributor.author]
Ozacmak H.S.
Yazar
[dc.contributor.author]
Cabuk M.
Yayın Yılı
[dc.date.issued]
2016
Yayıncı
[dc.publisher]
Taylor and Francis Ltd
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Background: The aim of the current study was to investigate whether agmatine (AGM) has a protective effect against cisplatin-induced nephrotoxicity. Materials and methods: Thirty-two rats were randomly divided into four groups: (1) Saline (control); (2) Cisplatin (CDDP; 7.5 mg/kg intraperitoneally); (3) Agmatine (AGM; 10 mg/kg intraperitoneally); (4) Cisplatin plus agmatine (CDDP + AGM). Agmatine was given before and two consecutive days after cisplatin injection. All the animals underwent renal scintigraphy with 99mTc-DMSA. The levels of serum creatinine, cystatin C, and blood urea nitrogen (BUN) were measured in addition to examination of the tissue samples with light microscopy. Acute renal injury was assessed with biochemical analyses, scintigraphic imaging, and histopathological evaluation. Results: In the cisplatin group, the levels of BUN, creatinine, and cystatin C were significantly higher than that of the controls. Histopathological examination showed remarkable damage of tubular and glomerular structures. Additionally, cisplatin caused markedly decreased renal 99mTc-DMSA uptake. AGM administration improved renal functions. Serum creatinine, BUN, and cystatin C levels had a tendency to normalize and, scintigraphic and histopathological findings showed significantly less evidence of renal toxicity than those observed in animals receiving cisplatin alone. Conclusions: Our data indicate that AGM has a protective effect against cisplatin-induced nephrotoxicity. Therefore, it may improve the therapeutic index of cisplatin. In addition, the early renal damage induced by cisplatin and protective effects of AGM against cisplatin nephrotoxicity was accurately demonstrated with 99mTc-DMSA renal scintigraphy. © 2016 Informa UK Limited, trading as Taylor & Francis Group.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
99mTc-DMSA
Konu Başlıkları
[dc.subject]
Agmatine
Konu Başlıkları
[dc.subject]
cisplatin
Konu Başlıkları
[dc.subject]
cystatin C
Konu Başlıkları
[dc.subject]
nephrotoxicity
Konu Başlıkları
[dc.subject]
scintigraphy
Künye
[dc.identifier.citation]
Salihoglu, Y. S., Elri, T., Gulle, K., Can, M., Aras, M., Ozacmak, H. S. ve Cabuk, M. (2016). Evaluation of the protective effect of agmatine against cisplatin nephrotoxicity with 99mTc-DMSA renal scintigraphy and cystatin-C. Renal Failure, 38(9), 1496–1502. doi:10.1080/0886022X.2016.1227919
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
0886022X
İlk Sayfa Sayısı
[dc.identifier.startpage]
1496
Son Sayfa Sayısı
[dc.identifier.endpage]
1502
Dergi Adı
[dc.relation.journal]
Renal Failure
Dergi Sayısı
[dc.identifier.issue]
9
Dergi Cilt Bilgisi
[dc.identifier.volume]
38
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1080/0886022X.2016.1227919
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/5783
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
25
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
11 Şubat 2024 21:51
Google Kontrol
Tıklayınız
cisplatin nephrotoxicity against protective 99mTc-DMSA cystatin creatinine levels scintigraphy Cisplatin examination addition intraperitoneally) Agmatine animals significantly scintigraphic damage histopathological cisplatin-induced effect agmatine showed markedly controls Histopathological improved functions decreased administration remarkable tubular glomerular structures caused
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