Dynamics of voltage-gated ion channels in cell membranes by the path probability method

Dynamics of voltage-gated ion channels in the excitable cell membranes is formulated by the path probability method of nonequilibrium statistical physics and approaches of the system toward the steady or equilibrium states are presented. For a single-particle noninteractive two-state model, a first-order rate equation or dynamic equation is derived by introducing the path probability rate coefficients which satisfy the detailed balancing relation. Using known parameters for the batrachotoxin (BTX)-modified sodium channels in giand squid axon as an example, the rate equation is solved and voltage dependence of the time constant (?) and its temperature effect are investigated. An increase in voltage caused a shift in ? towards shorter durations while increasing temperature caused a shift in time distribution towards longer durations. Results are compared with the kinetic model for the squid axon BTX-modified sodium channels by the cut-open axon technique and a very good agreement is found. © 2003 Elsevier B.V. All rights reserved.

Dergi Adı Physica A: Statistical Mechanics and its Applications
Dergi Cilt Bilgisi 331
Dergi Sayısı 01.Feb
Sayfalar 51 - 60
Yayın Yılı 2004
Eser Adı
[dc.title]
Dynamics of voltage-gated ion channels in cell membranes by the path probability method
Yazar
[dc.contributor.author]
Özer, Mahmut
Yazar
[dc.contributor.author]
Erdem, Rıza
Yayın Yılı
[dc.date.issued]
2004
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Dynamics of voltage-gated ion channels in the excitable cell membranes is formulated by the path probability method of nonequilibrium statistical physics and approaches of the system toward the steady or equilibrium states are presented. For a single-particle noninteractive two-state model, a first-order rate equation or dynamic equation is derived by introducing the path probability rate coefficients which satisfy the detailed balancing relation. Using known parameters for the batrachotoxin (BTX)-modified sodium channels in giand squid axon as an example, the rate equation is solved and voltage dependence of the time constant (?) and its temperature effect are investigated. An increase in voltage caused a shift in ? towards shorter durations while increasing temperature caused a shift in time distribution towards longer durations. Results are compared with the kinetic model for the squid axon BTX-modified sodium channels by the cut-open axon technique and a very good agreement is found. © 2003 Elsevier B.V. All rights reserved.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Dynamics
Konu Başlıkları
[dc.subject]
Path probability method
Konu Başlıkları
[dc.subject]
Voltage-gated ion channels
Künye
[dc.identifier.citation]
Özer, M. ve Erdem, R. (2004). Dynamics of voltage-gated ion channels in cell membranes by the path probability method. Physica A: Statistical Mechanics and its Applications, 331(1), 51–60. doi:https://doi.org/10.1016/j.physa.2003.09.010
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0378-4371
İlk Sayfa Sayısı
[dc.identifier.startpage]
51
Son Sayfa Sayısı
[dc.identifier.endpage]
60
Dergi Adı
[dc.relation.journal]
Physica A: Statistical Mechanics and its Applications
Dergi Sayısı
[dc.identifier.issue]
01.Feb
Dergi Cilt Bilgisi
[dc.identifier.volume]
331
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1016/j.physa.2003.09.010
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/5228
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
19
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
09 Şubat 2024 07:12
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Tıklayınız
channels equation durations voltage caused towards probability temperature sodium increase investigated constant shorter effect compared increasing reserved rights Elsevier agreement distribution technique cut-open BTX-modified kinetic Results longer dependence Dynamics solved physics presented states equilibrium steady
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