Rosiglitazone treatment reduces hippocampal neuronal damage possibly through alleviating oxidative stress in chronic cerebral hypoperfusion

Oxygen free radicals and lipid peroxidation may play significant roles in the progress of injury induced by chronic cerebral hypoperfusion of the central nervous system. Rosiglitazone, a well known activator of PPAR?, has neuroprotective properties in various animal models of acute central nervous system damage. In the present study, we evaluate the possible impact of rosiglitazone on chronic cerebral hypoperfused-rats in regard to the levels of oxidative stress, reduced glutathione, and hippocampal neuronal damage. Chronic cerebral hypoperfusion was generated by permanent ligation of both common carotid arteries of Wistar rats for one month. Animals in treatment group were given rosiglitazone orally at doses of 1.5, 3, or 6 mg/kg per day of the 1 month duration. The treatment significantly lowered the levels of both malondialdehyde and neuronal damage, while elevated the reduced glutathione level markedly. These findings suggest that the beneficial effect of rosiglitazone on hypoperfusion-induced hippocampal neuronal damage might be the result of inhibition of oxidative insult. © 2012 Elsevier Ltd. All rights reserved.

Dergi Adı Neurochemistry International
Dergi Cilt Bilgisi 61
Dergi Sayısı 3
Sayfalar 287 - 290
Yayın Yılı 2012
Eser Adı
[dc.title]
Rosiglitazone treatment reduces hippocampal neuronal damage possibly through alleviating oxidative stress in chronic cerebral hypoperfusion
Yazar
[dc.contributor.author]
Özaçmak-Sayan, Hale
Yazar
[dc.contributor.author]
Özaçmak, Veysel Haktan
Yazar
[dc.contributor.author]
Barut, Figen
Yazar
[dc.contributor.author]
Jakubowska-Doğru, Ewa
Yayın Yılı
[dc.date.issued]
2012
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Oxygen free radicals and lipid peroxidation may play significant roles in the progress of injury induced by chronic cerebral hypoperfusion of the central nervous system. Rosiglitazone, a well known activator of PPAR?, has neuroprotective properties in various animal models of acute central nervous system damage. In the present study, we evaluate the possible impact of rosiglitazone on chronic cerebral hypoperfused-rats in regard to the levels of oxidative stress, reduced glutathione, and hippocampal neuronal damage. Chronic cerebral hypoperfusion was generated by permanent ligation of both common carotid arteries of Wistar rats for one month. Animals in treatment group were given rosiglitazone orally at doses of 1.5, 3, or 6 mg/kg per day of the 1 month duration. The treatment significantly lowered the levels of both malondialdehyde and neuronal damage, while elevated the reduced glutathione level markedly. These findings suggest that the beneficial effect of rosiglitazone on hypoperfusion-induced hippocampal neuronal damage might be the result of inhibition of oxidative insult. © 2012 Elsevier Ltd. All rights reserved.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Chronic cerebral hypoperfusion
Konu Başlıkları
[dc.subject]
Oxidative stress
Konu Başlıkları
[dc.subject]
Rosiglitazone
Künye
[dc.identifier.citation]
Sayan-Ozacmak, H., Ozacmak, V. H., Barut, F., & Jakubowska-Dogru, E. (2012). Rosiglitazone treatment reduces hippocampal neuronal damage possibly through alleviating oxidative stress in chronic cerebral hypoperfusion. Neurochemistry International, 61(3), 287–290. https://doi.org/https://doi.org/10.1016/j.neuint.2012.05.011
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0197-0186
Sponsor YAYINCI
[dc.description.sponsorship]
SBAG-HD-303, 108S114 National Council for Scientific Research
Sponsor YAYINCI
[dc.description.sponsorship]
We have gratefully acknowledged the Research Projects Fund of Turkish Scientific Research Council (TUBITAK) for providing financial support that made the present study possible (the grant # 108S114, SBAG-HD-303 ).
İlk Sayfa Sayısı
[dc.identifier.startpage]
287
Son Sayfa Sayısı
[dc.identifier.endpage]
290
Dergi Adı
[dc.relation.journal]
Neurochemistry International
Dergi Sayısı
[dc.identifier.issue]
3
Dergi Cilt Bilgisi
[dc.identifier.volume]
61
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1016/j.neuint.2012.05.011
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/7455
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
39
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
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08 Şubat 2024 14:26
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Tıklayınız
damage cerebral rosiglitazone neuronal central reduced glutathione hippocampal system nervous hypoperfusion chronic oxidative treatment levels Oxygen duration orally reserved rights Elsevier insult inhibition result hypoperfusion-induced significantly effect beneficial suggest findings markedly elevated malondialdehyde lowered Animals
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