Eicosanoids mediate Galleria mellonella cellular immune response to viral infection

Nodulation is the predominant insect cellular immune response to bacterial and fungal infections and it can also be induced by some viral infections. Treating seventh instar larvae of greater wax moth Galleria mellonella with Bovine herpes simplex virus-1 (BHSV-1) induced nodulation reactions in a dose-dependent manner. Because eicosanoids mediate nodulation reactions to bacterial and fungal infection, we hypothesized that eicosanoids also mediate nodulation reactions to viral challenge. To test this idea, we injected G. mellonella larvae with indomethacin, a nonsteroidal anti-inflammatory drug immediately prior to intrahemocoelic injection of BHSV-1. Relative to vehicle-treated controls, indomethacin-treated larvae produced significantly reduced numbers of nodules following viral infection (down from approximately 190 nodules/larva to <50 nodules/larva). In addition to injection treatments, increasing dietary indomethacin dosages (from 0.01% to 1%) were associated with decreasing nodulation (by 10-fold) and phenoloxidase activity (by 3-fold) reactions to BHSV-1 injection. We infer from these findings that cyclooxygenase products, prostaglandins, mediate nodulation response to viral infection in G. mellonella. © 2006 Elsevier Ltd. All rights reserved.

Eser Adı
[dc.title]
Eicosanoids mediate Galleria mellonella cellular immune response to viral infection
Yazar
[dc.contributor.author]
Büyükgüzel, Ender
Yazar
[dc.contributor.author]
Tunaz , Hasan
Yazar
[dc.contributor.author]
Stanley, David
Yazar
[dc.contributor.author]
Büyükgüzel, Kemal
Yayın Yılı
[dc.date.issued]
2007
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Nodulation is the predominant insect cellular immune response to bacterial and fungal infections and it can also be induced by some viral infections. Treating seventh instar larvae of greater wax moth Galleria mellonella with Bovine herpes simplex virus-1 (BHSV-1) induced nodulation reactions in a dose-dependent manner. Because eicosanoids mediate nodulation reactions to bacterial and fungal infection, we hypothesized that eicosanoids also mediate nodulation reactions to viral challenge. To test this idea, we injected G. mellonella larvae with indomethacin, a nonsteroidal anti-inflammatory drug immediately prior to intrahemocoelic injection of BHSV-1. Relative to vehicle-treated controls, indomethacin-treated larvae produced significantly reduced numbers of nodules following viral infection (down from approximately 190 nodules/larva to <50 nodules/larva). In addition to injection treatments, increasing dietary indomethacin dosages (from 0.01% to 1%) were associated with decreasing nodulation (by 10-fold) and phenoloxidase activity (by 3-fold) reactions to BHSV-1 injection. We infer from these findings that cyclooxygenase products, prostaglandins, mediate nodulation response to viral infection in G. mellonella. © 2006 Elsevier Ltd. All rights reserved.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Cellular immunity
Konu Başlıkları
[dc.subject]
G. mellonella
Konu Başlıkları
[dc.subject]
Indomethacin
Konu Başlıkları
[dc.subject]
Nodulation
Konu Başlıkları
[dc.subject]
Phenoloxidase
Künye
[dc.identifier.citation]
Büyükgüzel, E., Tunaz, H., Stanley, D. ve Büyükgüzel, K. (2007). Eicosanoids mediate Galleria mellonella cellular immune response to viral infection. Journal of Insect Physiology, 53(1), 99-105. doi:10.1016/j.jinsphys.2006.10.012
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0022-1910
İlk Sayfa Sayısı
[dc.identifier.startpage]
99
Son Sayfa Sayısı
[dc.identifier.endpage]
105
Dergi Adı
[dc.relation.journal]
Journal of Insect Physiology
Dergi Sayısı
[dc.identifier.issue]
1
Dergi Cilt Bilgisi
[dc.identifier.volume]
53
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1016/j.jinsphys.2006.10.012
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/5570
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nodulation reactions injection infection mellonella larvae mediate eicosanoids indomethacin infections induced BHSV-1 response bacterial fungal nodules/larva numbers nodules following dietary dosages increasing treatments addition approximately nodules/larva) decreasing findings reserved rights Elsevier prostaglandins products cyclooxygenase 3-fold)
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