Attenuation of contractile dysfunction by atorvastatin after intestinal ischemia reperfusion injury in rats

Growing number of studies implicate that 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, or statins, have beneficial effects on ischemia/reperfusion injury that are unrelated to their cholesterol-lowering action. In the present study, we aimed to evaluate possible effects of atorvastatin on oxidative stress, neutrophil accumulation, and contractile response of terminal ileum segments in rats subjected to intestinal ischemia/reperfusion. Intestinal ischemia/reperfusion model was generated by clamping the superior mesenteric artery for 30 min followed by reperfusion for 3 h. Oral administration of atorvastatin at a dose of 10 mg/kg/day lasted 3 days just before induction of intestinal ischemia. At the end of reperfusion period, terminal ileum samples were removed to determine the concentrations of malondialdehyde, reduced glutathione, and myeloperoxidase. Samples were collected also to assess histopathological alterations and contractile response to agonists. Ischemia/reperfusion significantly decreased contractile responses, and this decrease was attenuated by atorvastatin. Pretreatment with atorvastatin caused remarkable decrease in both oxidative stress and neutrophil accumulation. Atorvastatin appeared to be restoring amount of reduced glutathione back to about control level. Furthermore, the pretreatment lowered mucosal damage at histopathological level. Our results suggested that pretreatment with atorvastatin attenuated intestinal muscle dysfunction associated with ischemia/reperfusion. This remarkable effect of atorvastatin is accomplished at least by decreasing oxidative stress and neutrophil accumulation as well as preventing the depletion of reduced glutathione. © 2007 Elsevier B.V. All rights reserved.

Dergi Adı European Journal of Pharmacology
Dergi Cilt Bilgisi 562
Dergi Sayısı 01.Feb
Sayfalar 138 - 147
Yayın Yılı 2007
Eser Adı
[dc.title]
Attenuation of contractile dysfunction by atorvastatin after intestinal ischemia reperfusion injury in rats
Yazar
[dc.contributor.author]
Özaçmak, Veysel Haktan
Yazar
[dc.contributor.author]
Sayan, Hale
Yazar
[dc.contributor.author]
Akyıldız-İğdem, Ayşenur
Yazar
[dc.contributor.author]
Çetin, Alpay
Yazar
[dc.contributor.author]
Özaçmak, İhsan Diler
Yayın Yılı
[dc.date.issued]
2007
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Growing number of studies implicate that 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, or statins, have beneficial effects on ischemia/reperfusion injury that are unrelated to their cholesterol-lowering action. In the present study, we aimed to evaluate possible effects of atorvastatin on oxidative stress, neutrophil accumulation, and contractile response of terminal ileum segments in rats subjected to intestinal ischemia/reperfusion. Intestinal ischemia/reperfusion model was generated by clamping the superior mesenteric artery for 30 min followed by reperfusion for 3 h. Oral administration of atorvastatin at a dose of 10 mg/kg/day lasted 3 days just before induction of intestinal ischemia. At the end of reperfusion period, terminal ileum samples were removed to determine the concentrations of malondialdehyde, reduced glutathione, and myeloperoxidase. Samples were collected also to assess histopathological alterations and contractile response to agonists. Ischemia/reperfusion significantly decreased contractile responses, and this decrease was attenuated by atorvastatin. Pretreatment with atorvastatin caused remarkable decrease in both oxidative stress and neutrophil accumulation. Atorvastatin appeared to be restoring amount of reduced glutathione back to about control level. Furthermore, the pretreatment lowered mucosal damage at histopathological level. Our results suggested that pretreatment with atorvastatin attenuated intestinal muscle dysfunction associated with ischemia/reperfusion. This remarkable effect of atorvastatin is accomplished at least by decreasing oxidative stress and neutrophil accumulation as well as preventing the depletion of reduced glutathione. © 2007 Elsevier B.V. All rights reserved.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Contractile function
Konu Başlıkları
[dc.subject]
Intestinal ischemia
Konu Başlıkları
[dc.subject]
Oxidative stress
Konu Başlıkları
[dc.subject]
Statin
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0014-2999
İlk Sayfa Sayısı
[dc.identifier.startpage]
138
Son Sayfa Sayısı
[dc.identifier.endpage]
147
Dergi Adı
[dc.relation.journal]
European Journal of Pharmacology
Dergi Sayısı
[dc.identifier.issue]
01.Feb
Dergi Cilt Bilgisi
[dc.identifier.volume]
562
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1016/j.ejphar.2007.01.061
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/4434
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
39
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
09 Şubat 2024 12:30
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Tıklayınız
atorvastatin ischemia/reperfusion glutathione stress neutrophil accumulation contractile intestinal oxidative reduced attenuated histopathological decrease terminal response reperfusion remarkable pretreatment effects caused Elsevier Pretreatment responses appeared decreased significantly Ischemia/reperfusion agonists alterations rights assess collected reserved Atorvastatin restoring
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