Morphine modulates inducible nitric oxide synthase expression and reduces pulmonary oedema induced by α-naphthylthiourea

This study was designed to investigate the possible participation of morphine in pulmonary oedema induced by ?-naphthylthiourea (ANTU), which is a well-known noxious chemical agent in the lung. Injection of ANTU (15 mg/kg i.p.) produced pulmonary oedema as indicated by an increase in lung weight/body weight ratio and pleural effusion reaching a maximum within 4 h in rat. Administration of morphine prior to ANTU significantly inhibited to pulmonary oedema with a dose-dependent manner. The protective effect of morphine is prevented by peripheral opioid receptor antagonist, naloxone methiodide. ANTU-treated rats were shown positive by inducible nitric oxide synthase immunohistochemical staining. There was no staining in the control group. On the other hand, the degree of staining was markedly reduced in tissue sections by morphine. These results suggest that previous administration of subcutaneous morphine has preventive effect on ANTU-induced pulmonary inflammatory reaction and its effect mediated via peripheral opioid receptors. Application of naloxone with ANTU has no effect on the lung parameters indicating that endogenous opioids do not modulate ANTU-induced damage. © 2005 Elsevier B.V. All rights reserved.

Yazar Cömert, Mustafa
Sipahi, Emine Yılmaz
Üstün, Hüseyin
Işıkdemir, Fulden
Numanoğlu, Gamze
Barut, Figen
Altunkaya, Hanife
Özer, Yetkin
Ayoğlu, Ferruh Niyazi
Sipahi, Tunç Hakan
Tekin, İshak Özel
Banoğlu, Z. Nur
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/6667
Tek Biçim Adres 10.1016/j.ejphar.2005.01.038
Konu Başlıkları Inflammation
Morphine
Naloxone methiodide
Pulmonary oedema
?-Naphthylthiourea
Koleksiyonlar Fakülteler
Tıp Fakültesi
Cerrahi Bilimler Bölümü
Makale Koleksiyonu (Cerrahi Bilimler Bölümü)
Fakülteler
Tıp Fakültesi
Dahili Tıp Bilimleri
Makale Koleksiyonu (Dahili Tıp Bilimleri)
Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı European Journal of Pharmacology
Dergi Cilt Bilgisi 511
Dergi Sayısı 02.Mar
Sayfalar 183 - 189
Yayın Yılı 2005
Eser Adı
[dc.title]
Morphine modulates inducible nitric oxide synthase expression and reduces pulmonary oedema induced by α-naphthylthiourea
Yazar
[dc.contributor.author]
Cömert, Mustafa
Yazar
[dc.contributor.author]
Sipahi, Emine Yılmaz
Yazar
[dc.contributor.author]
Üstün, Hüseyin
Yazar
[dc.contributor.author]
Işıkdemir, Fulden
Yazar
[dc.contributor.author]
Numanoğlu, Gamze
Yazar
[dc.contributor.author]
Barut, Figen
Yazar
[dc.contributor.author]
Altunkaya, Hanife
Yazar
[dc.contributor.author]
Özer, Yetkin
Yazar
[dc.contributor.author]
Ayoğlu, Ferruh Niyazi
Yazar
[dc.contributor.author]
Sipahi, Tunç Hakan
Yazar
[dc.contributor.author]
Tekin, İshak Özel
Yazar
[dc.contributor.author]
Banoğlu, Z. Nur
Yayın Yılı
[dc.date.issued]
2005
Yayıncı
[dc.publisher]
Elsevier
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
This study was designed to investigate the possible participation of morphine in pulmonary oedema induced by ?-naphthylthiourea (ANTU), which is a well-known noxious chemical agent in the lung. Injection of ANTU (15 mg/kg i.p.) produced pulmonary oedema as indicated by an increase in lung weight/body weight ratio and pleural effusion reaching a maximum within 4 h in rat. Administration of morphine prior to ANTU significantly inhibited to pulmonary oedema with a dose-dependent manner. The protective effect of morphine is prevented by peripheral opioid receptor antagonist, naloxone methiodide. ANTU-treated rats were shown positive by inducible nitric oxide synthase immunohistochemical staining. There was no staining in the control group. On the other hand, the degree of staining was markedly reduced in tissue sections by morphine. These results suggest that previous administration of subcutaneous morphine has preventive effect on ANTU-induced pulmonary inflammatory reaction and its effect mediated via peripheral opioid receptors. Application of naloxone with ANTU has no effect on the lung parameters indicating that endogenous opioids do not modulate ANTU-induced damage. © 2005 Elsevier B.V. All rights reserved.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Inflammation
Konu Başlıkları
[dc.subject]
Morphine
Konu Başlıkları
[dc.subject]
Naloxone methiodide
Konu Başlıkları
[dc.subject]
Pulmonary oedema
Konu Başlıkları
[dc.subject]
?-Naphthylthiourea
Künye
[dc.identifier.citation]
Comert, M., Sipahi, E. Y., Ustun, H., Isikdemir, F., Numanoglu, G., Barut, F., … Banoglu, Z. N. (2005). Morphine modulates inducible nitric oxide synthase expression and reduces pulmonary oedema induced by α-naphthylthiourea. European Journal of Pharmacology, 511(2–3), 183–189. doi:10.1016/j.ejphar.2005.01.038
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0014-2999
Sponsor YAYINCI
[dc.description.sponsorship]
The authors would like to thank Dr. E. Schilliger, Schering AG, Berlin, Germany, for his gift of ?-naphthylthiourea (Interchem). We thank Hasan Tahsin Yilmaz and Ramazan Temel for their assistance in research laboratory. This study was supported by intramural funding from Zonguldak Karaelmas University's Office of Research and Sponsored Programs.
İlk Sayfa Sayısı
[dc.identifier.startpage]
183
Son Sayfa Sayısı
[dc.identifier.endpage]
189
Dergi Adı
[dc.relation.journal]
European Journal of Pharmacology
Dergi Sayısı
[dc.identifier.issue]
02.Mar
Dergi Cilt Bilgisi
[dc.identifier.volume]
511
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1016/j.ejphar.2005.01.038
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/6667
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morphine pulmonary effect staining oedema ANTU-induced opioid peripheral naloxone sections synthase immunohistochemical suggest results previous tissue markedly degree control reduced administration reserved rights Elsevier damage modulate opioids subcutaneous endogenous indicating parameters Application receptors mediated inducible
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