A computer software for simulating single-compartmental model of neurons

In this paper, a new computer software package, Yalzer, is introduced for simulating single-compartmental model of neurons. Passive or excitable membranes with voltage-gated ion channels can be modeled, and current clamp and voltage clamp experiments can be simulated. In the Yalzer, first-order differential equations used to define the dynamics of the gate variables and the membrane potential are solved by two separate integration methods with variable time steps: forward Euler and exponential Euler methods. Outputs of the simulation are shown on a spreadsheet template for allowing flexible data manipulation and can be graphically displayed. The user can define the model in detail, and examine the excitability of the model and the dynamics of voltage-gated ion channels. The software package addresses to ones who want to run simple simulations of neurons without need to any programming language skills or expensive software. It can also be used for educational purposes. © 2003 Elsevier Ireland Ltd. All rights reserved.

Eser Adı
[dc.title]
A computer software for simulating single-compartmental model of neurons
Yazar
[dc.contributor.author]
Özer, Mahmut
Yazar
[dc.contributor.author]
İşler, Yalçın
Yazar
[dc.contributor.author]
Özer, Halil
Yayın Yılı
[dc.date.issued]
2004
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
In this paper, a new computer software package, Yalzer, is introduced for simulating single-compartmental model of neurons. Passive or excitable membranes with voltage-gated ion channels can be modeled, and current clamp and voltage clamp experiments can be simulated. In the Yalzer, first-order differential equations used to define the dynamics of the gate variables and the membrane potential are solved by two separate integration methods with variable time steps: forward Euler and exponential Euler methods. Outputs of the simulation are shown on a spreadsheet template for allowing flexible data manipulation and can be graphically displayed. The user can define the model in detail, and examine the excitability of the model and the dynamics of voltage-gated ion channels. The software package addresses to ones who want to run simple simulations of neurons without need to any programming language skills or expensive software. It can also be used for educational purposes. © 2003 Elsevier Ireland Ltd. All rights reserved.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Computer software
Konu Başlıkları
[dc.subject]
Excitable membranes
Konu Başlıkları
[dc.subject]
Neuronal modeling
Konu Başlıkları
[dc.subject]
Simulation
Konu Başlıkları
[dc.subject]
Voltage-gated ion channels
Künye
[dc.identifier.citation]
Ozer, M., Isler, Y. ve Ozer, H. (2004). A computer software for simulating single-compartmental model of neurons. Computer Methods and Programs in Biomedicine, 75(1), 51–57. doi:https://doi.org/10.1016/j.cmpb.2003.08.002
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0169-2607
İlk Sayfa Sayısı
[dc.identifier.startpage]
51
Son Sayfa Sayısı
[dc.identifier.endpage]
57
Dergi Adı
[dc.relation.journal]
Computer Methods and Programs in Biomedicine
Dergi Sayısı
[dc.identifier.issue]
1
Dergi Cilt Bilgisi
[dc.identifier.volume]
75
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1016/j.cmpb.2003.08.002
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/3916
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
53
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
06 Şubat 2024 19:25
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Tıklayınız
software channels methods define voltage-gated dynamics package neurons Yalzer simple manipulation graphically addresses detail excitability displayed examine expensive simulations purposes reserved rights Ireland Elsevier educational without allowing skills language programming flexible integration template excitable first-order
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