Influence of Soybean Oil Blending with Polylactic Acid (PLA) Films: In Vitro and In Vivo Evaluation

Due to the great interest in oil-based polymers, which are prepared from renewable resources, different forms and amounts of soybean oil-based PLA films were prepared and evaluated for their potential usage as a medical biomaterial. Soybean oil, epoxidized soybean oil and auto-oxidized soybean oil were blended with PLA and PLA/oil films with appropriate oil amounts [2, 7, 14 and 20% (w/w)] were obtained by solvent casting. Thermal stability and plasticization effect were determined by adjusting oil amounts and type. Epoxidized soybean oil blended films showed the smallest increase in elongation breaks (13–20%) and the highest decrease in thermal decomposition temperatures (364–327 °C) compared to other oil blended films. In vitro quantitative and qualitative cytotoxicity results showed no reactivity (grade 0) for the L929 cells treated with 14% (w/w) oil blended PLA films. In vivo irritation and implantation tests concluded that 14% (w/w) oil blended PLA films were non-irritant. No erythema, no oedema reactions, no traumatic necrosis and foreign debris were observed. Thus, along with superior biocompatibility, PLA/oil films can replace petroleum-based products for several biomedical uses. © 2017, AOCS.

Eser Adı
[dc.title]
Influence of Soybean Oil Blending with Polylactic Acid (PLA) Films: In Vitro and In Vivo Evaluation
Yazar
[dc.contributor.author]
Aydın, R. Seda Tığlı
Yazar
[dc.contributor.author]
Akyol, Elvan
Yazar
[dc.contributor.author]
Hazer, Baki
Yayın Yılı
[dc.date.issued]
2017
Yayıncı
[dc.publisher]
Springer Verlag
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Due to the great interest in oil-based polymers, which are prepared from renewable resources, different forms and amounts of soybean oil-based PLA films were prepared and evaluated for their potential usage as a medical biomaterial. Soybean oil, epoxidized soybean oil and auto-oxidized soybean oil were blended with PLA and PLA/oil films with appropriate oil amounts [2, 7, 14 and 20% (w/w)] were obtained by solvent casting. Thermal stability and plasticization effect were determined by adjusting oil amounts and type. Epoxidized soybean oil blended films showed the smallest increase in elongation breaks (13–20%) and the highest decrease in thermal decomposition temperatures (364–327 °C) compared to other oil blended films. In vitro quantitative and qualitative cytotoxicity results showed no reactivity (grade 0) for the L929 cells treated with 14% (w/w) oil blended PLA films. In vivo irritation and implantation tests concluded that 14% (w/w) oil blended PLA films were non-irritant. No erythema, no oedema reactions, no traumatic necrosis and foreign debris were observed. Thus, along with superior biocompatibility, PLA/oil films can replace petroleum-based products for several biomedical uses. © 2017, AOCS.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Biocompatibility
Konu Başlıkları
[dc.subject]
Epoxidized soybean oil
Konu Başlıkları
[dc.subject]
PLA
Konu Başlıkları
[dc.subject]
Soybean oil
Künye
[dc.identifier.citation]
Aydın, R. S. T., Akyol, E. ve Hazer, B. (2017). Influence of soybean oil blending with polylactic acid (Pla) films: In vitro and in vivo evaluation. Journal of the American Oil Chemists’ Society, 94(3), 413-424. doi:10.1007/s11746-017-2954-6
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0003021X
İlk Sayfa Sayısı
[dc.identifier.startpage]
413
Son Sayfa Sayısı
[dc.identifier.endpage]
424
Dergi Adı
[dc.relation.journal]
JAOCS, Journal of the American Oil Chemists' Society
Dergi Sayısı
[dc.identifier.issue]
3
Dergi Cilt Bilgisi
[dc.identifier.volume]
94
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1007/s11746-017-2954-6
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/6249
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blended soybean amounts showed PLA/oil oil-based prepared implantation irritation quantitative treated qualitative (grade reactivity results cytotoxicity concluded non-irritant biocompatibility biomedical several products petroleum-based replace superior observed debris foreign necrosis traumatic reactions (364–327 °C) oedema erythema compared
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