Biodegradable poly(ε-caprolactone)-based graft copolymers via poly(linoleic acid): In vitro enzymatic evaluation

Well-defined graft copolymers based on poly(?-caprolactone) (PCL) via poly(linoleic acid) (PLina), are derived from soybean oil. Poly(linoleic acid)-g-poly(?-caprolactone) (PLina-g-PCL) and poly(linoleic acid)-g-poly(styrene)-g-poly(?-caprolactone) (PLina-g-PSt-g-PCL) were synthesized by ring-opening polymerization of ?-caprolactone initiated by PLina and one-pot synthesis of graft copolymers, and by ring-opening polymerization and free radical polymerization by using PLina, respectively. PLina-g-PCL, PLina-g-PSt-g-PCL3, and PLina-g-PSt-g-PCL4 copolymers containing 96.97, 75.04 and 80.34 mol% CL, respectively, have been investigated regarding their enzymatic degradation properties in the presence of Pseudomonas lipase. In terms of weight loss, after 1 month, 51.5% of PLina-g-PCL, 18.8% of PLina-g-PSt-g-PCL3, and 38.4% of PLina-g-PSt-g-PCL4 were degraded, leaving remaining copolymers with molecular weights of 16,140, 83,220 and 70,600 Da, respectively. Introducing the PLina unit into the copolymers greatly decreased the degradation rate. The molar ratio of [CL]/[Lina] dramatically decreased, from 21.3 to 8.4, after 30 days of incubation. Moreover, reduced PCL content in PLina-g-PSt-g-PCL copolymers decreased the degradation rate, probably due to the PSt enrichment within the structure, which blocks lipase contact with PCL units. Thus, copolymerization of PCL with PLina and PSt units leads to a controllable degradation profile, which encourages the use of these polymers as promising biomaterials for tissue engineering applications. © AOCS 2015.

Dergi Adı JAOCS, Journal of the American Oil Chemists' Society
Dergi Cilt Bilgisi 92
Dergi Sayısı 3
Sayfalar 449 - 458
Yayın Yılı 2015
Eser Adı
[dc.title]
Biodegradable poly(ε-caprolactone)-based graft copolymers via poly(linoleic acid): In vitro enzymatic evaluation
Yazar
[dc.contributor.author]
Allı, Sema
Yazar
[dc.contributor.author]
Tığlı-Aydın, Rahime Seda
Yazar
[dc.contributor.author]
Allı, Abdülkadir
Yazar
[dc.contributor.author]
Hazer, Baki
Yayın Yılı
[dc.date.issued]
2015
Yayıncı
[dc.publisher]
Springer Verlag
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Well-defined graft copolymers based on poly(?-caprolactone) (PCL) via poly(linoleic acid) (PLina), are derived from soybean oil. Poly(linoleic acid)-g-poly(?-caprolactone) (PLina-g-PCL) and poly(linoleic acid)-g-poly(styrene)-g-poly(?-caprolactone) (PLina-g-PSt-g-PCL) were synthesized by ring-opening polymerization of ?-caprolactone initiated by PLina and one-pot synthesis of graft copolymers, and by ring-opening polymerization and free radical polymerization by using PLina, respectively. PLina-g-PCL, PLina-g-PSt-g-PCL3, and PLina-g-PSt-g-PCL4 copolymers containing 96.97, 75.04 and 80.34 mol% CL, respectively, have been investigated regarding their enzymatic degradation properties in the presence of Pseudomonas lipase. In terms of weight loss, after 1 month, 51.5% of PLina-g-PCL, 18.8% of PLina-g-PSt-g-PCL3, and 38.4% of PLina-g-PSt-g-PCL4 were degraded, leaving remaining copolymers with molecular weights of 16,140, 83,220 and 70,600 Da, respectively. Introducing the PLina unit into the copolymers greatly decreased the degradation rate. The molar ratio of [CL]/[Lina] dramatically decreased, from 21.3 to 8.4, after 30 days of incubation. Moreover, reduced PCL content in PLina-g-PSt-g-PCL copolymers decreased the degradation rate, probably due to the PSt enrichment within the structure, which blocks lipase contact with PCL units. Thus, copolymerization of PCL with PLina and PSt units leads to a controllable degradation profile, which encourages the use of these polymers as promising biomaterials for tissue engineering applications. © AOCS 2015.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Enzymatic degradation
Konu Başlıkları
[dc.subject]
Poly(linoleic acid)
Konu Başlıkları
[dc.subject]
Poly(styrene)
Konu Başlıkları
[dc.subject]
Poly(ε-caprolactone)
Künye
[dc.identifier.citation]
Alli, S., Tiiğlı-Aydin, R. S., Alli, A. ve Hazer, B. (2015). Biodegradable poly(ε-caprolactone)-based graft copolymers via poly(linoleic acid): In vitro enzymatic evaluation. JAOCS, Journal of the American Oil Chemists’ Society, 92(3), 449–458. doi:10.1007/s11746-015-2611-x
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0003021X
İlk Sayfa Sayısı
[dc.identifier.startpage]
449
Son Sayfa Sayısı
[dc.identifier.endpage]
458
Dergi Adı
[dc.relation.journal]
JAOCS, Journal of the American Oil Chemists' Society
Dergi Sayısı
[dc.identifier.issue]
3
Dergi Cilt Bilgisi
[dc.identifier.volume]
92
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1007/s11746-015-2611-x
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/4505
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copolymers degradation decreased respectively polymerization PLina-g-PCL lipase PLina-g-PSt-g-PCL3 poly(linoleic PLina-g-PSt-g-PCL4 ring-opening incubation Introducing Moreover dramatically [CL]/[Lina] greatly Well-defined structure reduced encourages applications engineering tissue biomaterials promising polymers profile content controllable copolymerization contact blocks within enrichment
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