Polymeric linoleic acid-polyolefin conjugates: Cell adhesion and biocompatibility

To diversify edible-oil polymer composite, polymeric linoleic acid (PLina) peroxide was obtained by the auto-oxidation of linoleic acid in a simple way for use as a macroinitiator in free radical polymerization of vinyl monomers. Peroxidation, epoxidation, and/or perepoxidation reactions of linoleic acid under air at room temperature resulted in PLina, having soluble fraction more than 91 weight percent (wt%), with molecular weight ranging from 1,644 to 2,763 Da, and containing up to 1.0 wt% of peroxide. PLina initiated the free radical polymerization of ether styrene (S), methyl methacrylate (MMA), or n-butyl methacrylate (nBMA) to give PLina-g-polystyrene (PS), PLina-g-poly-MMA (PMMA), and PLina-g-poly- nBMA (PnBMA) graft copolymers. The polymers obtained were characterized by proton nuclear magnetic resonance (1H NMR), thermal gravimetric analysis (TGA), differential scanning calorimetry (DSC), and gel permeation chromatography (GPC) techniques. Microstructure of the graft copolymers was observed by using scanning electron microscope (SEM). Graft copolymers obtained contained polymeric linoleic acid in a range between 8.5 and 19.3 mol percent (mol%). PLina-g-PS, PLina-g-PMMA and PLina-g-PnBMA graft copolymer samples were also used in cell culture studies. Fibroblast and macrophage cells were strongly adhered and spread on the copolymer film surfaces. These newly synthesized copolymers were tested for their effects on human blood protein adsorption compared with PMMA graft copolymers containing polymeric soybean oil and polymeric linseed oil; interestingly we observed a dramatic decrease in the protein adsorption on the linoleic acid graft copolymer, which is important in tissue engineering. © AOCS 2007.

Eser Adı
[dc.title]
Polymeric linoleic acid-polyolefin conjugates: Cell adhesion and biocompatibility
Yazar
[dc.contributor.author]
Çakmaklı, Birten
Yazar
[dc.contributor.author]
Hazer, Baki
Yazar
[dc.contributor.author]
Tekin, İshak Özel
Yazar
[dc.contributor.author]
Açıkgöz, Şerefden
Yazar
[dc.contributor.author]
Can, Murat
Yayın Yılı
[dc.date.issued]
2007
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
To diversify edible-oil polymer composite, polymeric linoleic acid (PLina) peroxide was obtained by the auto-oxidation of linoleic acid in a simple way for use as a macroinitiator in free radical polymerization of vinyl monomers. Peroxidation, epoxidation, and/or perepoxidation reactions of linoleic acid under air at room temperature resulted in PLina, having soluble fraction more than 91 weight percent (wt%), with molecular weight ranging from 1,644 to 2,763 Da, and containing up to 1.0 wt% of peroxide. PLina initiated the free radical polymerization of ether styrene (S), methyl methacrylate (MMA), or n-butyl methacrylate (nBMA) to give PLina-g-polystyrene (PS), PLina-g-poly-MMA (PMMA), and PLina-g-poly- nBMA (PnBMA) graft copolymers. The polymers obtained were characterized by proton nuclear magnetic resonance (1H NMR), thermal gravimetric analysis (TGA), differential scanning calorimetry (DSC), and gel permeation chromatography (GPC) techniques. Microstructure of the graft copolymers was observed by using scanning electron microscope (SEM). Graft copolymers obtained contained polymeric linoleic acid in a range between 8.5 and 19.3 mol percent (mol%). PLina-g-PS, PLina-g-PMMA and PLina-g-PnBMA graft copolymer samples were also used in cell culture studies. Fibroblast and macrophage cells were strongly adhered and spread on the copolymer film surfaces. These newly synthesized copolymers were tested for their effects on human blood protein adsorption compared with PMMA graft copolymers containing polymeric soybean oil and polymeric linseed oil; interestingly we observed a dramatic decrease in the protein adsorption on the linoleic acid graft copolymer, which is important in tissue engineering. © AOCS 2007.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Blood compatibility
Konu Başlıkları
[dc.subject]
Fibroblast cell
Konu Başlıkları
[dc.subject]
Graft copolymer
Konu Başlıkları
[dc.subject]
Macroinitiator
Konu Başlıkları
[dc.subject]
Macrophage cell
Konu Başlıkları
[dc.subject]
Methyl methacrylate
Konu Başlıkları
[dc.subject]
n-butyl methacrylate
Konu Başlıkları
[dc.subject]
Polymeric linoleic acid
Konu Başlıkları
[dc.subject]
Protein adsorption
Konu Başlıkları
[dc.subject]
Styrene
Künye
[dc.identifier.citation]
Çakmaklı, B., Hazer, B., Tekin, İ. Ö., Açıkgöz, Ş. ve Can, M. (2007). Polymeric linoleic acid–polyolefin conjugates: Cell adhesion and biocompatibility. Journal of the American Oil Chemists’ Society, 84(1), 73-81. doi:10.1007/s11746-006-1011-7
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0003021X
Sponsor YAYINCI
[dc.description.sponsorship]
104M128
Sponsor YAYINCI
[dc.description.sponsorship]
Acknowledgment This work was financially supported by Zonguldak Karaelmas University Research Fund and partially supported by TÜBİTAK research project (Grant no. 104M128).
İlk Sayfa Sayısı
[dc.identifier.startpage]
73
Son Sayfa Sayısı
[dc.identifier.endpage]
81
Dergi Adı
[dc.relation.journal]
JAOCS, Journal of the American Oil Chemists' Society
Dergi Sayısı
[dc.identifier.issue]
1
Dergi Cilt Bilgisi
[dc.identifier.volume]
84
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1007/s11746-006-1011-7
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/7057
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copolymers linoleic polymeric obtained copolymer methacrylate scanning weight protein adsorption percent polymerization observed peroxide containing radical techniques samples permeation chromatography PLina-g-PnBMA PLina-g-PMMA microscope Microstructure PLina-g-PS (mol%) electron between contained culture soybean linseed interestingly dramatic decrease
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