AT1 receptor blocker candesartan-induced attenuation of brain injury of rats subjected to chronic cerebral hypoperfusion

One of common pathophysiological states associated with central nervous system is chronic cerebral hypoperfusion (CH) that frequently occurs in conditions such as vascular dementia and Alzheimer's disease. Long term blockage of angiotensin II type 1 (AT 1 ) receptor provides protection from ischemia induced injury of brain as well as reduction of cerebrovascular inflammation. Examining effect of the blockage on reduced glutathione (GSH), ascorbic acid (AA), and lipid peroxidation were of purpose in the present study. Modeling CH, rats were subjected to permanent occlusion of common carotid arteries bilaterally. AT 1 receptor antagonist, candesartan, was given daily for 14 days after surgery. CH caused a significant increase in lipid peroxidation and decrease in GSH content of cerebral hippocampal tissue with no change in AA level. Candesartan (0.5 mg/kg, oral) not only reduced lipid peroxidation but also restored GSH significantly besides elevating AA and improving histopathological alterations. In conclusion, long term AT 1 receptor blockage may be considered as novel therapeutic approach for protection from damage associated with CH. Underlying mechanism(s) may in part be related to suppressing oxidative stress and preserving brain antioxidant capacity. © 2007 Springer Science+Business Media, LLC.

Dergi Adı Neurochemical Research
Dergi Cilt Bilgisi 32
Dergi Sayısı 8
Sayfalar 1314 - 1321
Yayın Yılı 2007
Eser Adı
[dc.title]
AT1 receptor blocker candesartan-induced attenuation of brain injury of rats subjected to chronic cerebral hypoperfusion
Yazar
[dc.contributor.author]
Özaçmak, Veysel Haktan
Yazar
[dc.contributor.author]
Sayan, Hale
Yazar
[dc.contributor.author]
Çetin, Alpay
Yazar
[dc.contributor.author]
Akyıldız-İğdem, Ayşenur
Yayın Yılı
[dc.date.issued]
2007
Yayıncı
[dc.publisher]
Springer New York
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
One of common pathophysiological states associated with central nervous system is chronic cerebral hypoperfusion (CH) that frequently occurs in conditions such as vascular dementia and Alzheimer's disease. Long term blockage of angiotensin II type 1 (AT 1 ) receptor provides protection from ischemia induced injury of brain as well as reduction of cerebrovascular inflammation. Examining effect of the blockage on reduced glutathione (GSH), ascorbic acid (AA), and lipid peroxidation were of purpose in the present study. Modeling CH, rats were subjected to permanent occlusion of common carotid arteries bilaterally. AT 1 receptor antagonist, candesartan, was given daily for 14 days after surgery. CH caused a significant increase in lipid peroxidation and decrease in GSH content of cerebral hippocampal tissue with no change in AA level. Candesartan (0.5 mg/kg, oral) not only reduced lipid peroxidation but also restored GSH significantly besides elevating AA and improving histopathological alterations. In conclusion, long term AT 1 receptor blockage may be considered as novel therapeutic approach for protection from damage associated with CH. Underlying mechanism(s) may in part be related to suppressing oxidative stress and preserving brain antioxidant capacity. © 2007 Springer Science+Business Media, LLC.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Ascorbic acid
Konu Başlıkları
[dc.subject]
AT 1 receptor blockage
Konu Başlıkları
[dc.subject]
Chronic cerebral hypoperfusion
Konu Başlıkları
[dc.subject]
Glutathione
Konu Başlıkları
[dc.subject]
Oxidative stress
Künye
[dc.identifier.citation]
Ozacmak, V.H., Sayan, H., Cetin, A. et al. AT1 Receptor Blocker Candesartan-induced Attenuation of Brain Injury of Rats Subjected to Chronic Cerebral Hypoperfusion. Neurochem Res 32, 1314–1321 (2007). https://doi.org/10.1007/s11064-007-9305-1
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0364-3190
İlk Sayfa Sayısı
[dc.identifier.startpage]
1314
Son Sayfa Sayısı
[dc.identifier.endpage]
1321
Dergi Adı
[dc.relation.journal]
Neurochemical Research
Dergi Sayısı
[dc.identifier.issue]
8
Dergi Cilt Bilgisi
[dc.identifier.volume]
32
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1007/s11064-007-9305-1
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/4426
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
37
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
17 Şubat 2024 08:11
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Tıklayınız
receptor blockage peroxidation protection reduced cerebral common associated Science+Business capacity Candesartan Springer change tissue hippocampal content decrease increase significant caused surgery approach therapeutic damage Underlying mechanism(s) considered related suppressing conclusion oxidative stress alterations histopathological improving
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