Vitamin E protects against acetone-induced oxidative stress in rat red blood cells

Acetone may induce oxidative stress leading to disturbance of the biochemical and physiological functions of red blood cells (RBCs) thereby affecting membrane integrity. Vitamin E (vit E) is believed to function as an antioxidant in vivo protecting membranes from lipid peroxidation. The aim of the present study was the evaluation of possible protective effects of vit E treatment against acetone-induced oxidative stress in rat RBCs. Thirty healthy male Wistar albino rats, weighing 200-230 g and averaging 12 weeks old were randomly allotted into one of three experimental groups: Control (A), acetone-treated (B) and acetone + vit E-treated groups (C), each containing ten animals. Group A received only drinking water. Acetone, 5% (v/v), was given with drinking water to B and C groups. In addition, C group received vit E dose of 200 mg/kg/day i.m. The experiment continued for 10 days. At the end of the 10th day, the blood samples were obtained for biochemical and morphological investigation. Acetone treatment resulted in RBC membrane destruction and hemolysis, increased thiobarbituric acid reactive substance (TEARS) levels in plasma and RBC, and decreased RBC vit E levels. Vit E treatment decreased elevated TEARS levels in plasma and RBC and also increased reduced RBC vit E levels, and prevented RBC membrane destruction and hemolysis. In conclusion, vit E treatment appears to be beneficial in preventing acetone-induced oxidative RBC damage, and therefore, it can improve RBC rheology. © 2005 Springer.

Eser Adı
[dc.title]
Vitamin E protects against acetone-induced oxidative stress in rat red blood cells
Yazar
[dc.contributor.author]
Armutçu, Feraf
Yazar
[dc.contributor.author]
Coşkun, Ömer Faruk
Yazar
[dc.contributor.author]
Gürel, Aykut
Yazar
[dc.contributor.author]
Şahin, S.
Yazar
[dc.contributor.author]
Kanter, Marek
Yazar
[dc.contributor.author]
Cihan, Ali
Yazar
[dc.contributor.author]
Numanoğlu, Kemal Varın
Yayın Yılı
[dc.date.issued]
2005
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Acetone may induce oxidative stress leading to disturbance of the biochemical and physiological functions of red blood cells (RBCs) thereby affecting membrane integrity. Vitamin E (vit E) is believed to function as an antioxidant in vivo protecting membranes from lipid peroxidation. The aim of the present study was the evaluation of possible protective effects of vit E treatment against acetone-induced oxidative stress in rat RBCs. Thirty healthy male Wistar albino rats, weighing 200-230 g and averaging 12 weeks old were randomly allotted into one of three experimental groups: Control (A), acetone-treated (B) and acetone + vit E-treated groups (C), each containing ten animals. Group A received only drinking water. Acetone, 5% (v/v), was given with drinking water to B and C groups. In addition, C group received vit E dose of 200 mg/kg/day i.m. The experiment continued for 10 days. At the end of the 10th day, the blood samples were obtained for biochemical and morphological investigation. Acetone treatment resulted in RBC membrane destruction and hemolysis, increased thiobarbituric acid reactive substance (TEARS) levels in plasma and RBC, and decreased RBC vit E levels. Vit E treatment decreased elevated TEARS levels in plasma and RBC and also increased reduced RBC vit E levels, and prevented RBC membrane destruction and hemolysis. In conclusion, vit E treatment appears to be beneficial in preventing acetone-induced oxidative RBC damage, and therefore, it can improve RBC rheology. © 2005 Springer.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Acetone
Konu Başlıkları
[dc.subject]
Hemolysis
Konu Başlıkları
[dc.subject]
Lipid peroxidation
Konu Başlıkları
[dc.subject]
Red blood cell
Konu Başlıkları
[dc.subject]
Vitamin E
Künye
[dc.identifier.citation]
Armutcu, F., Coskun, Ö., Gürel, A., Sahin, S., Kanter, M., Cihan, A., … Altınyazar, C.. (2005). Vitamin E protects against acetone-induced oxidative stress in rat red blood cells. Cell Biology and Toxicology. Cell Biology and Toxicology. doi:10.1007/s10565-005-1781-y
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0742-2091
İlk Sayfa Sayısı
[dc.identifier.startpage]
53
Son Sayfa Sayısı
[dc.identifier.endpage]
60
Dergi Adı
[dc.relation.journal]
Cell Biology and Toxicology
Dergi Sayısı
[dc.identifier.issue]
1
Dergi Cilt Bilgisi
[dc.identifier.volume]
21
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1007/s10565-005-1781-y
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/8515
Tam Metin İndirmek için tıklayın Ön izleme
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
30
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
18 Şubat 2024 21:51
Google Kontrol
Tıklayınız
levels treatment groups membrane oxidative Acetone hemolysis plasma destruction acetone-induced drinking received decreased increased stress biochemical continued experiment mg/kg/day improve addition rheology Springer elevated reduced prevented conclusion (TEARS) substance reactive appears thiobarbituric beneficial preventing damage
6698 sayılı Kişisel Verilerin Korunması Kanunu kapsamında yükümlülüklerimiz ve çerez politikamız hakkında bilgi sahibi olmak için alttaki bağlantıyı kullanabilirsiniz.

creativecommons
Bu site altında yer alan tüm kaynaklar Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.
Platforms