Osteogenic activities of polymeric soybean oil-g-polystyrene membranes

A novel biocompatible copolymer membrane was synthesized and characterized for use in guided bone regeneration using polymeric soybean oil-g-polystyrene (PSO-g-PS) graft copolymer which was successfully obtained by free radical polymerization of styrene initiated by PSO peroxide as a macroinitiator at 80 C. Osteoblastic cellular activities of MC3T3-E1 cells on PSO-g-PS membranes with different soybean oil composition (PSO-g-PS1, PSO-g-PS2, and PSO-g-PS3) were evaluated. Nuclear magnetic resonance (1H NMR) spectra showed that PSO inclusion (mol%) was found to be 27, 69, and 51 % for PSO-g-PS1, PSO-g-PS2, and PSO-g-PS3 membranes, respectively. Superior biocompatibility of the PSO-g-PS membranes was determined compared to polystyrene tissue culture plates (TCPS) as positive control. Cell proliferation was enhanced on PSO-g-PS2 and PSO-g-PS3 membranes compared to PSO-g-PS1 membranes (p < 0.001), and a statistically significant higher ALP value of MC3T3-E1 cells on PSO-g-PS2 membranes (p < 0.05) suggested that proliferation and differentiation of preosteoblastic on PSO-g-PS membranes were enhanced with regard to soybean oil content within the membranes. Thus, the present study suggests that PSO-g-PS2 membranes, which showed a favorable biological environment for the preosteoblastic cells, can be well suited for bone tissue engineering applications. © 2013 Springer-Verlag Berlin Heidelberg.

Eser Adı
[dc.title]
Osteogenic activities of polymeric soybean oil-g-polystyrene membranes
Yazar
[dc.contributor.author]
Tığlı-Aydın, Rahime Seda
Yazar
[dc.contributor.author]
Hazer, Baki
Yazar
[dc.contributor.author]
Acar, Merve
Yazar
[dc.contributor.author]
Gümüşderelioğlu, Menemşe
Yayın Yılı
[dc.date.issued]
2013
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
A novel biocompatible copolymer membrane was synthesized and characterized for use in guided bone regeneration using polymeric soybean oil-g-polystyrene (PSO-g-PS) graft copolymer which was successfully obtained by free radical polymerization of styrene initiated by PSO peroxide as a macroinitiator at 80 C. Osteoblastic cellular activities of MC3T3-E1 cells on PSO-g-PS membranes with different soybean oil composition (PSO-g-PS1, PSO-g-PS2, and PSO-g-PS3) were evaluated. Nuclear magnetic resonance (1H NMR) spectra showed that PSO inclusion (mol%) was found to be 27, 69, and 51 % for PSO-g-PS1, PSO-g-PS2, and PSO-g-PS3 membranes, respectively. Superior biocompatibility of the PSO-g-PS membranes was determined compared to polystyrene tissue culture plates (TCPS) as positive control. Cell proliferation was enhanced on PSO-g-PS2 and PSO-g-PS3 membranes compared to PSO-g-PS1 membranes (p < 0.001), and a statistically significant higher ALP value of MC3T3-E1 cells on PSO-g-PS2 membranes (p < 0.05) suggested that proliferation and differentiation of preosteoblastic on PSO-g-PS membranes were enhanced with regard to soybean oil content within the membranes. Thus, the present study suggests that PSO-g-PS2 membranes, which showed a favorable biological environment for the preosteoblastic cells, can be well suited for bone tissue engineering applications. © 2013 Springer-Verlag Berlin Heidelberg.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Bone tissue engineering
Konu Başlıkları
[dc.subject]
Cell-biomaterial interaction
Konu Başlıkları
[dc.subject]
Soybean oil
Konu Başlıkları
[dc.subject]
Styrene
Künye
[dc.identifier.citation]
Tığlı Aydın, R. S., Hazer, B., Acar, M. ve Gümüşderelioğlu, M. (2013). Osteogenic activities of polymeric soybean oil-g-polystyrene membranes. Polymer Bulletin, 70(7), 2065-2082. doi:10.1007/s00289-013-0976-2
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0170-0839
İlk Sayfa Sayısı
[dc.identifier.startpage]
2065
Son Sayfa Sayısı
[dc.identifier.endpage]
2082
Dergi Adı
[dc.relation.journal]
Polymer Bulletin
Dergi Sayısı
[dc.identifier.issue]
7
Dergi Cilt Bilgisi
[dc.identifier.volume]
70
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1007/s00289-013-0976-2
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/6886
Tam Metin İndirmek için tıklayın Ön izleme
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
48
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
09 Şubat 2024 08:52
Google Kontrol
Tıklayınız
membranes PSO-g-PS2 PSO-g-PS soybean MC3T3-E1 showed preosteoblastic enhanced proliferation tissue compared PSO-g-PS1 PSO-g-PS3 copolymer plates engineering control positive Heidelberg (TCPS) biocompatibility determined applications suited polystyrene Springer-Verlag Berlin culture significant content differentiation suggested Superior within higher
6698 sayılı Kişisel Verilerin Korunması Kanunu kapsamında yükümlülüklerimiz ve çerez politikamız hakkında bilgi sahibi olmak için alttaki bağlantıyı kullanabilirsiniz.

creativecommons
Bu site altında yer alan tüm kaynaklar Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.
Platforms