Treatment of severe amitriptyline intoxication with plasmapheresis

Tricyclic antidepressant poisoning is one of the most common causes of serious intoxication. Here, we report a 2-year-old girl with severe amitriptyline (70 mg/kg) intoxication. She was in comatose, had generalized tonic clonic seizure, ventricular tachycardia, and wide QRS complexes. Although she did not respond to classical therapies, very good clinical response to plasmapheresis was obtained and she developed no complications. Thus, plasmapheresis may be an effective treatment modality in poisoning with drugs, which bind to plasma proteins with high affinity. © 2009 Wiley-Liss, Inc.

Eser Adı
[dc.title]
Treatment of severe amitriptyline intoxication with plasmapheresis
Yazar
[dc.contributor.author]
Kolsal, Ebru
Yazar
[dc.contributor.author]
Tekin, İshak Özel
Yazar
[dc.contributor.author]
Pişkin, Etem
Yazar
[dc.contributor.author]
Aydemir, Cumhur
Yazar
[dc.contributor.author]
Akyüz, Mehmet
Yazar
[dc.contributor.author]
Çabuk, Hasan
Yazar
[dc.contributor.author]
Eldes, Nilüfer
Yazar
[dc.contributor.author]
Numanoğlu, Kemal Varın
Yayın Yılı
[dc.date.issued]
2009
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Tricyclic antidepressant poisoning is one of the most common causes of serious intoxication. Here, we report a 2-year-old girl with severe amitriptyline (70 mg/kg) intoxication. She was in comatose, had generalized tonic clonic seizure, ventricular tachycardia, and wide QRS complexes. Although she did not respond to classical therapies, very good clinical response to plasmapheresis was obtained and she developed no complications. Thus, plasmapheresis may be an effective treatment modality in poisoning with drugs, which bind to plasma proteins with high affinity. © 2009 Wiley-Liss, Inc.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Amitriptyline
Konu Başlıkları
[dc.subject]
Intoxication
Konu Başlıkları
[dc.subject]
Plasmapheresis
Künye
[dc.identifier.citation]
Kolsal, E., Tekin, I. Ö., Piskin, E., Aydemir, C., Akyüz, M., Çabuk, H., … Numanoglu, V.. (2009). Treatment of severe amitriptyline intoxication with plasmapheresis. Journal of Clinical Apheresis. Journal of Clinical Apheresis. doi:10.1002/jca.20185
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0733-2459
İlk Sayfa Sayısı
[dc.identifier.startpage]
21
Son Sayfa Sayısı
[dc.identifier.endpage]
24
Dergi Adı
[dc.relation.journal]
Journal of Clinical Apheresis
Dergi Sayısı
[dc.identifier.issue]
1
Dergi Cilt Bilgisi
[dc.identifier.volume]
24
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1002/jca.20185
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/8386
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plasmapheresis intoxication poisoning clinical therapies response obtained developed complications classical Tricyclic proteins Wiley-Liss affinity plasma modality treatment respond effective amitriptyline common causes serious report 2-year-old severe mg/kg) comatose generalized clonic seizure ventricular tachycardia antidepressant complexes
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