Synthesis and characterization of ozonated oil nanoemulsions

In recent years, the use of ozonated oil (ozone enriched oil form) is being increasingly preferred for biomedical applications because of its antibacterial activity. Among most important reasons of this choice is the high molecular affinity of the ozone molecule and intracellular effects of the products of ozone and the unsaturated fatty-acid chemical reactions in cellular signaling systems. The aim of the present study was to synthesize and optimize the ozonated oil nanoemulsion system that would be transferred into the living systems easily, suggesting a promising carrier system for various biomedical applications. By varying formulation parameters (surfactant-to-oil ratio, surfactant concentration, mixing rate, and surfactant type), nanoemulsions were investigated in terms of mean particle diameters, distributions, and stabilities. Nanoemulsions with high stability and small droplet diameters (212.7 nm) could be produced under optimized conditions with Tween 40 as the surfactant at a 750 rpm mixing rate using the emulsion inversion point (EIP) low-energy method. Spherical and uniformly distributed nanoemulsions were observed by SEM, which also supports mean particle diameter measurements. Fourier-transform infrared spectroscopy (FTIR) and 13C NMR (nuclear magnetic resonance) studies indicated an ozonide structure within the nanoemulsion system, which remained even after 30 days of storage. The antibacterial activity of ozonated oil emulsions against Staphylococcus aureus and Escherichia coli suggests promising applications in the biomedical field. © 2018 AOCS

Dergi Adı JAOCS, Journal of the American Oil Chemists' Society
Dergi Cilt Bilgisi 95
Dergi Sayısı 11
Sayfalar 1385 - 1398
Yayın Yılı 2018
Eser Adı
[dc.title]
Synthesis and characterization of ozonated oil nanoemulsions
Yazar
[dc.contributor.author]
Tığlı-Aydın, Rahime Seda
Yazar
[dc.contributor.author]
Kazancı, Füsun
Yayın Yılı
[dc.date.issued]
2018
Yayıncı
[dc.publisher]
Wiley-Blackwell
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
In recent years, the use of ozonated oil (ozone enriched oil form) is being increasingly preferred for biomedical applications because of its antibacterial activity. Among most important reasons of this choice is the high molecular affinity of the ozone molecule and intracellular effects of the products of ozone and the unsaturated fatty-acid chemical reactions in cellular signaling systems. The aim of the present study was to synthesize and optimize the ozonated oil nanoemulsion system that would be transferred into the living systems easily, suggesting a promising carrier system for various biomedical applications. By varying formulation parameters (surfactant-to-oil ratio, surfactant concentration, mixing rate, and surfactant type), nanoemulsions were investigated in terms of mean particle diameters, distributions, and stabilities. Nanoemulsions with high stability and small droplet diameters (212.7 nm) could be produced under optimized conditions with Tween 40 as the surfactant at a 750 rpm mixing rate using the emulsion inversion point (EIP) low-energy method. Spherical and uniformly distributed nanoemulsions were observed by SEM, which also supports mean particle diameter measurements. Fourier-transform infrared spectroscopy (FTIR) and 13C NMR (nuclear magnetic resonance) studies indicated an ozonide structure within the nanoemulsion system, which remained even after 30 days of storage. The antibacterial activity of ozonated oil emulsions against Staphylococcus aureus and Escherichia coli suggests promising applications in the biomedical field. © 2018 AOCS
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Antibacterial
Konu Başlıkları
[dc.subject]
Nanoemulsion
Konu Başlıkları
[dc.subject]
Ozonated oil
Konu Başlıkları
[dc.subject]
Ozone
Künye
[dc.identifier.citation]
Tığlı-Aydın, R. S. ve Kazancı, F. (2018). Synthesis and characterization of ozonated oil nanoemulsions. Journal of the American Oil Chemists’ Society, 95(11), 1385-1398. doi:10.1002/aocs.12150
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0003021X
Sponsor YAYINCI
[dc.description.sponsorship]
Firat University Scientific Research Projects Management Unit: 2015-3997 1044-01
Sponsor YAYINCI
[dc.description.sponsorship]
Acknowledgments This study was supported by Bülent Ecevit University Scientific Research Projects, Project Number: 2015-3997 1044-01. We would like to thank Microbiota Biotechnology (Turkey) for technical assistance of the antimicrobial activity tests.
İlk Sayfa Sayısı
[dc.identifier.startpage]
1385
Son Sayfa Sayısı
[dc.identifier.endpage]
1398
Dergi Adı
[dc.relation.journal]
JAOCS, Journal of the American Oil Chemists' Society
Dergi Sayısı
[dc.identifier.issue]
11
Dergi Cilt Bilgisi
[dc.identifier.volume]
95
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1002/aocs.12150
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/7737
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
45
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
09 Şubat 2024 08:53
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Tıklayınız
surfactant system ozonated applications biomedical mixing promising systems nanoemulsions nanoemulsion particle activity diameters antibacterial observed distributed uniformly Spherical produced optimized conditions method low-energy inversion emulsion against storage emulsions Staphylococcus within aureus Escherichia suggests remained structure
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