Function of voltage-gated ionic channels

In this paper, we investigate dynamics of voltage-gated ionic channels which are of great importance in integrating the information received by neurons. Understanding of dynamical behavior of voltage-gated ionic channels plays a major role for determining underlying mechanism of spike activity and predicting the neuronal behavior. Investigation is carried out based on Hodgkin-Huxley (H-H) mathematical formalism. Ionic channel gate model is discussed briefly. Relaxation phenomenon is studied in the gate variables. Then effects of temperature on dynamics of gate variables are examined. Finally voltage-clamped simulations are carried out to determine their dynamic behaviors based on squid giant axon.

In this paper, we investigate dynamics of voltage-gated ionic channels which are of great importance in integrating the information received by neurons. Understanding of dynamical behavior of voltage-gated ionic channels plays a major role for determining underlying mechanism of spike activity and predicting the neuronal behavior. Investigation is carried out based on Hodgkin-Huxley (H-H) mathematical formalism. Ionic channel gate model is discussed briefly. Relaxation phenomenon is studied in the gate variables. Then effects of temperature on dynamics of gate variables are examined. Finally voltage-clamped simulations are carried out to determine their dynamic behaviors based on squid giant axon.

Dergi Adı Istanbul University Journal of Electrical and Electronics Engineering
Dergi Cilt Bilgisi 4
Dergi Sayısı 1
Sayfalar 1091 - 1104
Yayın Yılı 2004
Eser Adı
[dc.title]
Function of voltage-gated ionic channels
Yazar
[dc.contributor.author]
Özer, Mahmut
Yazar
[dc.contributor.author]
Bal, Abdullah
Yayın Yılı
[dc.date.issued]
2004
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
In this paper, we investigate dynamics of voltage-gated ionic channels which are of great importance in integrating the information received by neurons. Understanding of dynamical behavior of voltage-gated ionic channels plays a major role for determining underlying mechanism of spike activity and predicting the neuronal behavior. Investigation is carried out based on Hodgkin-Huxley (H-H) mathematical formalism. Ionic channel gate model is discussed briefly. Relaxation phenomenon is studied in the gate variables. Then effects of temperature on dynamics of gate variables are examined. Finally voltage-clamped simulations are carried out to determine their dynamic behaviors based on squid giant axon.
Özet
[dc.description.abstract]
In this paper, we investigate dynamics of voltage-gated ionic channels which are of great importance in integrating the information received by neurons. Understanding of dynamical behavior of voltage-gated ionic channels plays a major role for determining underlying mechanism of spike activity and predicting the neuronal behavior. Investigation is carried out based on Hodgkin-Huxley (H-H) mathematical formalism. Ionic channel gate model is discussed briefly. Relaxation phenomenon is studied in the gate variables. Then effects of temperature on dynamics of gate variables are examined. Finally voltage-clamped simulations are carried out to determine their dynamic behaviors based on squid giant axon.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Mühendislik
Konu Başlıkları
[dc.subject]
Elektrik ve Elektronik
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
1303-0914
İlk Sayfa Sayısı
[dc.identifier.startpage]
1091
Son Sayfa Sayısı
[dc.identifier.endpage]
1104
Dergi Adı
[dc.relation.journal]
Istanbul University Journal of Electrical and Electronics Engineering
Dergi Sayısı
[dc.identifier.issue]
1
Dergi Cilt Bilgisi
[dc.identifier.volume]
4
Tek Biçim Adres
[dc.identifier.uri]
http://www.trdizin.gov.tr/publication/paper/detail/TmpFME1EazU=
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/1785
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300
09.12.2022 tarihinden bu yana
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1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
17 Temmuz 2024 21:13
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Tıklayınız
variables behavior channels voltage-gated dynamics carried discussed channel formalism mathematical Relaxation Hodgkin-Huxley briefly neuronal phenomenon studied effects examined Finally voltage-clamped simulations determine dynamic behaviors temperature predicting Investigation Understanding investigate importance integrating information received neurons dynamical
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