The effect of radiotherapy on cardiac function
BACKGROUND: Radiation-induced heart disease is a complication that may be encountered after radiotherapy (RT) of tumors in the vicinity of the heart. In this study, we aimed to evaluate the effect of RT on the heart, by comparing conventional and tissue Doppler echocardiography parameters obtained before and after RT. METHODS: Forty patients who had undergone RT for either lung or left breast cancer were included in the study. ECG, conventional, and tissue Doppler echocardiography were performed before and 4-6 weeks after RT. RESULTS: The mean value of the radiation dose applied to all regions of the heart was calculated as 13.1±2.2 Gy (maximum 41.7 Gy). The value for the left ventricle was 10.2±2.0 Gy (maximum 43.6 Gy). A decrease in early transmitral diastolic velocity (E), E/A ratio, EF, Em, and Em/Am, and an increase in E-wave deceleration time, isovolumic relaxation time, isovolumic contraction time, ejection time, and QTc were found after RT. CONCLUSION: We found detrimental effects of RT on systolic and diastolic cardiac functions and the electrical conduction system of the heart. Maximal prevention should be provided for the patients during RT. © 2012 Lippincott Williams & Wilkins, Inc.
| Yazar |
Dogan S.M. Bilici H.M. Bakkal, Bekir Hakan Aydin M. Karabag T. Sayin M.R. Aktop Z. |
| Yayın Türü | Article |
| Tek Biçim Adres | https://hdl.handle.net/20.500.12628/7982 |
| Konu Başlıkları |
diastolic dysfunction
ejection fraction radiotherapy tissue Doppler echocardiography |
| Koleksiyonlar |
Fakülteler Tıp Fakültesi Cerrahi Bilimler Bölümü Makale Koleksiyonu (Cerrahi Bilimler Bölümü) Fakülteler Tıp Fakültesi Dahili Tıp Bilimleri Makale Koleksiyonu (Dahili Tıp Bilimleri) Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD Scopus İndeksli Yayınlar Koleksiyonu Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD WoS İndeksli Yayınlar Koleksiyonu |
| Dergi Adı | Coronary Artery Disease |
| Dergi Cilt Bilgisi | 23 |
| Dergi Sayısı | 3 |
| Sayfalar | 146 - 154 |
| Yayın Yılı | 2012 |
| Eser Adı [dc.title] | The effect of radiotherapy on cardiac function |
| Yazar [dc.contributor.author] | Dogan S.M. |
| Yazar [dc.contributor.author] | Bilici H.M. |
| Yazar [dc.contributor.author] | Bakkal, Bekir Hakan |
| Yazar [dc.contributor.author] | Aydin M. |
| Yazar [dc.contributor.author] | Karabag T. |
| Yazar [dc.contributor.author] | Sayin M.R. |
| Yazar [dc.contributor.author] | Aktop Z. |
| Yayın Yılı [dc.date.issued] | 2012 |
| Yayın Türü [dc.type] | article |
| Özet [dc.description.abstract] | BACKGROUND: Radiation-induced heart disease is a complication that may be encountered after radiotherapy (RT) of tumors in the vicinity of the heart. In this study, we aimed to evaluate the effect of RT on the heart, by comparing conventional and tissue Doppler echocardiography parameters obtained before and after RT. METHODS: Forty patients who had undergone RT for either lung or left breast cancer were included in the study. ECG, conventional, and tissue Doppler echocardiography were performed before and 4-6 weeks after RT. RESULTS: The mean value of the radiation dose applied to all regions of the heart was calculated as 13.1±2.2 Gy (maximum 41.7 Gy). The value for the left ventricle was 10.2±2.0 Gy (maximum 43.6 Gy). A decrease in early transmitral diastolic velocity (E), E/A ratio, EF, Em, and Em/Am, and an increase in E-wave deceleration time, isovolumic relaxation time, isovolumic contraction time, ejection time, and QTc were found after RT. CONCLUSION: We found detrimental effects of RT on systolic and diastolic cardiac functions and the electrical conduction system of the heart. Maximal prevention should be provided for the patients during RT. © 2012 Lippincott Williams & Wilkins, Inc. |
| Kayıt Giriş Tarihi [dc.date.accessioned] | 2019-12-23 |
| Açık Erişim Tarihi [dc.date.available] | 2019-12-23 |
| Yayın Dili [dc.language.iso] | eng |
| Konu Başlıkları [dc.subject] | diastolic dysfunction |
| Konu Başlıkları [dc.subject] | ejection fraction |
| Konu Başlıkları [dc.subject] | radiotherapy |
| Konu Başlıkları [dc.subject] | tissue Doppler echocardiography |
| Haklar [dc.rights] | info:eu-repo/semantics/openAccess |
| ISSN [dc.identifier.issn] | 0954-6928 |
| İlk Sayfa Sayısı [dc.identifier.startpage] | 146 |
| Son Sayfa Sayısı [dc.identifier.endpage] | 154 |
| Dergi Adı [dc.relation.journal] | Coronary Artery Disease |
| Dergi Sayısı [dc.identifier.issue] | 3 |
| Dergi Cilt Bilgisi [dc.identifier.volume] | 23 |
| Tek Biçim Adres [dc.identifier.uri] | https://dx.doi.org/10.1097/MCA.0b013e32835115d6 |
| Tek Biçim Adres [dc.identifier.uri] | https://hdl.handle.net/20.500.12628/7982 |
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