Protection by L-carnitine against radiation-induced ileal mucosal injury in the rat: Pattern of oxidative stress, apoptosis and cytokines
Purpose: In this study, we tested the effects of L-carnitine (LC) on radiation-induced ileal mucosal damage. Materials and methods: Thirty Wistar albino rats were divided into five groups. The control group received physiological saline intraperitoneally (i.p.). Radiation-1 and radiation-2 groups received whole-body X-irradiation of 8.3 Gy as a single dose. These groups were sacrificed at the 6th hour and 4th day after irradiation, respectively. The Radiation-1 + LC and the radiation-2 + LC groups received the same dose irradiation plus a daily dose of 200 mg/kg LC. LC was applied one day before and for four days after irradiation. Results: The levels of serum monocyte chemotactic protein-1 (MCP-1) and interferon gamma (IFN-?) were significantly higher in the radiation groups when compared with the control. Treatment with LC decreased the serum MCP-1 and IFN-? levels considerably. In the radiations groups, the Chiu score was significantly elevated compared with that of the control group. However, LC administered prior to the irradiation reduced the severity of mucosal damage. The number of apoptotic cells of the ileal crypt in the irradiated rats increased from the 6th hour after irradiation and then decreased at 4th day. Conclusions: Our data demonstrated that LC may be beneficial to radiation enteritis. © 2013 Informa UK, Ltd.
| Yazar |
Akpolat M. Gulle K. Topcu-Tarladacalisir Y. Safi Oz Z. Bakkal, Bekir Hakan Arasli M. Ozel Turkcu U. |
| Yayın Türü | Article |
| Tek Biçim Adres | https://hdl.handle.net/20.500.12628/7227 |
| Tek Biçim Adres | 10.3109/09553002.2013.787176 |
| Konu Başlıkları |
Apoptosis
Cytokine Histopathology Intestine Oxidative stress Radiotherapy |
| Koleksiyonlar |
Fakülteler Tıp Fakültesi Cerrahi Bilimler Bölümü Makale Koleksiyonu (Cerrahi Bilimler Bölümü) Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD Scopus İndeksli Yayınlar Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu |
| Dergi Adı | International Journal of Radiation Biology |
| Dergi Cilt Bilgisi | 89 |
| Dergi Sayısı | 9 |
| Sayfalar | 732 - 740 |
| Yayın Yılı | 2013 |
| Eser Adı [dc.title] | Protection by L-carnitine against radiation-induced ileal mucosal injury in the rat: Pattern of oxidative stress, apoptosis and cytokines |
| Yazar [dc.contributor.author] | Akpolat M. |
| Yazar [dc.contributor.author] | Gulle K. |
| Yazar [dc.contributor.author] | Topcu-Tarladacalisir Y. |
| Yazar [dc.contributor.author] | Safi Oz Z. |
| Yazar [dc.contributor.author] | Bakkal, Bekir Hakan |
| Yazar [dc.contributor.author] | Arasli M. |
| Yazar [dc.contributor.author] | Ozel Turkcu U. |
| Yayın Yılı [dc.date.issued] | 2013 |
| Yayın Türü [dc.type] | article |
| Özet [dc.description.abstract] | Purpose: In this study, we tested the effects of L-carnitine (LC) on radiation-induced ileal mucosal damage. Materials and methods: Thirty Wistar albino rats were divided into five groups. The control group received physiological saline intraperitoneally (i.p.). Radiation-1 and radiation-2 groups received whole-body X-irradiation of 8.3 Gy as a single dose. These groups were sacrificed at the 6th hour and 4th day after irradiation, respectively. The Radiation-1 + LC and the radiation-2 + LC groups received the same dose irradiation plus a daily dose of 200 mg/kg LC. LC was applied one day before and for four days after irradiation. Results: The levels of serum monocyte chemotactic protein-1 (MCP-1) and interferon gamma (IFN-?) were significantly higher in the radiation groups when compared with the control. Treatment with LC decreased the serum MCP-1 and IFN-? levels considerably. In the radiations groups, the Chiu score was significantly elevated compared with that of the control group. However, LC administered prior to the irradiation reduced the severity of mucosal damage. The number of apoptotic cells of the ileal crypt in the irradiated rats increased from the 6th hour after irradiation and then decreased at 4th day. Conclusions: Our data demonstrated that LC may be beneficial to radiation enteritis. © 2013 Informa UK, Ltd. |
| Kayıt Giriş Tarihi [dc.date.accessioned] | 2019-12-23 |
| Açık Erişim Tarihi [dc.date.available] | 2019-12-23 |
| Yayın Dili [dc.language.iso] | eng |
| Konu Başlıkları [dc.subject] | Apoptosis |
| Konu Başlıkları [dc.subject] | Cytokine |
| Konu Başlıkları [dc.subject] | Histopathology |
| Konu Başlıkları [dc.subject] | Intestine |
| Konu Başlıkları [dc.subject] | Oxidative stress |
| Konu Başlıkları [dc.subject] | Radiotherapy |
| Haklar [dc.rights] | info:eu-repo/semantics/closedAccess |
| ISSN [dc.identifier.issn] | 0955-3002 |
| İlk Sayfa Sayısı [dc.identifier.startpage] | 732 |
| Son Sayfa Sayısı [dc.identifier.endpage] | 740 |
| Dergi Adı [dc.relation.journal] | International Journal of Radiation Biology |
| Dergi Sayısı [dc.identifier.issue] | 9 |
| Dergi Cilt Bilgisi [dc.identifier.volume] | 89 |
| Tek Biçim Adres [dc.identifier.uri] | https://dx.doi.org/10.3109/09553002.2013.787176 |
| Tek Biçim Adres [dc.identifier.uri] | https://hdl.handle.net/20.500.12628/7227 |
