Effect of treatment position and radiotherapy planning on testicular dose in patients with rectal carcinoma

Aims: The aim of this study was to evaluate and compare the effect of radiotherapy on testicles with different treatment positions and plans for rectal cancer patients. Settings and Design: Mono-institutional prospective study. Patients and Methods: Three different plans; supine 4-fields (s4f), prone 4-fields (p4f), and prone 3-fields (p3f) of 15 male patients with rectal carcinoma receiving 45 Gy pelvic radiotherapy were evaluated. Testicular doses in each plan were calculated. Since the localizations of the primary tumor may affect testicular dose, boost doses were not taken into account. Statistical Analysis Used: Kruskal Wallis test, Pearson and Spearman correlation analysis. Results: Median cumulative testicular doses of s4f, p4f, and p3f plans were 19.8, 69.3, and 100.8 cGy, respectively (P = 0.013). Median V0.5 (Volume receiving more than 0.5 Gy) and V1 (Volume receiving more than 1 Gy) for testicles were also significantly lower in s4f plans (3%, 60.7%, and 78.1% for V0.5 and 0.3%, 35.8%, and 52.3% for V1 in s4f, p4f, and p3f, respectively) (P = 0.001). The median distances between lower edge of fields and testicles in s4f, p4f, and p3f plans were 65 mm, 29 mm, and 29 mm, respectively (P < 0.01). Median bladder doses were significantly lower in p3f plans (P = 0.002). Conclusions: S4f external beam radiotherapy for rectal carcinoma allows better testicular dose than p3f and p4f. The probably reason was the increase of distance between lower edge of the field and testicles.

Dergi Adı Journal of Cancer Research and Therapeutics
Dergi Cilt Bilgisi 10
Dergi Sayısı 3
Sayfalar 558 - 562
Yayın Yılı 2014
Eser Adı
[dc.title]
Effect of treatment position and radiotherapy planning on testicular dose in patients with rectal carcinoma
Yazar
[dc.contributor.author]
Bakkal, Bekir Hakan
Yazar
[dc.contributor.author]
Vural T.
Yazar
[dc.contributor.author]
Elmas O.
Yazar
[dc.contributor.author]
Yildiz O.
Yazar
[dc.contributor.author]
Kokturk F.
Yayın Yılı
[dc.date.issued]
2014
Yayıncı
[dc.publisher]
Medknow Publications
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Aims: The aim of this study was to evaluate and compare the effect of radiotherapy on testicles with different treatment positions and plans for rectal cancer patients. Settings and Design: Mono-institutional prospective study. Patients and Methods: Three different plans; supine 4-fields (s4f), prone 4-fields (p4f), and prone 3-fields (p3f) of 15 male patients with rectal carcinoma receiving 45 Gy pelvic radiotherapy were evaluated. Testicular doses in each plan were calculated. Since the localizations of the primary tumor may affect testicular dose, boost doses were not taken into account. Statistical Analysis Used: Kruskal Wallis test, Pearson and Spearman correlation analysis. Results: Median cumulative testicular doses of s4f, p4f, and p3f plans were 19.8, 69.3, and 100.8 cGy, respectively (P = 0.013). Median V0.5 (Volume receiving more than 0.5 Gy) and V1 (Volume receiving more than 1 Gy) for testicles were also significantly lower in s4f plans (3%, 60.7%, and 78.1% for V0.5 and 0.3%, 35.8%, and 52.3% for V1 in s4f, p4f, and p3f, respectively) (P = 0.001). The median distances between lower edge of fields and testicles in s4f, p4f, and p3f plans were 65 mm, 29 mm, and 29 mm, respectively (P < 0.01). Median bladder doses were significantly lower in p3f plans (P = 0.002). Conclusions: S4f external beam radiotherapy for rectal carcinoma allows better testicular dose than p3f and p4f. The probably reason was the increase of distance between lower edge of the field and testicles.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Radiotherapy technique
Konu Başlıkları
[dc.subject]
rectal cancer
Konu Başlıkları
[dc.subject]
testicular dose
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0973-1482
İlk Sayfa Sayısı
[dc.identifier.startpage]
558
Son Sayfa Sayısı
[dc.identifier.endpage]
562
Dergi Adı
[dc.relation.journal]
Journal of Cancer Research and Therapeutics
Dergi Sayısı
[dc.identifier.issue]
3
Dergi Cilt Bilgisi
[dc.identifier.volume]
10
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.4103/0973-1482.137943
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/5400
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
24
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
09 Şubat 2024 12:30
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Tıklayınız
testicles rectal Median radiotherapy testicular receiving (Volume significantly between respectively carcinoma 4-fields different patients better external distance allows probably reason increase Conclusions median fields respectively) distances bladder Mono-institutional 3-fields supine Methods Patients prospective Design Settings
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