The results of hypofractionated radiotherapy in 31 patients with high-grade gliomas

In this prospective study, we investigated the effects of hypofractionated radiotherapy for patients with high-grade gliomas. About 31 patients with glioblastoma multiforme or anaplastic astrocytoma were studied between October 2003 and December 2004. Hypofractionated radiotherapy (3 Gy/fraction/day) was delivered to a total dose of 45 Gy in 15 fractions in 10 patients (32%) who had total excision before radiotherapy and to a total dose of 54 Gy in 18 fractions in 21 patients (68%) who had subtotal excision or biopsy alone. Sex, age, type of surgery, tumor grade, Karnofsky performance status, time between surgery and initiation of radiotherapy, and total radiotherapy dose were analyzed as potential prognostic factors for survival using the univariate log-rank method. The median follow-up was 15 months (4-16 months). A total of 15 patients (48%) died of their illness; 16 patients (52%) were still alive at the last follow-up. The median survival time was 8 months. Actuarial 1-year overall survival was 40%. Type of surgery, timing of radiotherapy after surgery, and initial Karnofsky performance status were significant prognostic factors for survival. No grade 3-4 acute or late neurotoxicity was observed. The tolerance of patients to hypofractionated RT was not different from that for con- ventional radiotherapy. This treatment schedule can be used for patients with high-grade gliomas. Future investigations are needed to determine the optimal fractionation for high-grade gliomas.

Dergi Adı MEDICAL ONCOLOGY
Dergi Cilt Bilgisi 24
Dergi Sayısı 4
Sayfalar 379 - 383
Yayın Yılı 2007
Eser Adı
[dc.title]
The results of hypofractionated radiotherapy in 31 patients with high-grade gliomas
Yazar
[dc.contributor.author]
Sayin, Meral Y.
Yazar
[dc.contributor.author]
Kaya, Bektas
Yazar
[dc.contributor.author]
Bakkal, Bekir Hakan
Yazar
[dc.contributor.author]
Altundag, Kadri
Yazar
[dc.contributor.author]
Altundag, Muzaffer B.
Yayın Yılı
[dc.date.issued]
2007
Yayıncı
[dc.publisher]
HUMANA PRESS INC
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
In this prospective study, we investigated the effects of hypofractionated radiotherapy for patients with high-grade gliomas. About 31 patients with glioblastoma multiforme or anaplastic astrocytoma were studied between October 2003 and December 2004. Hypofractionated radiotherapy (3 Gy/fraction/day) was delivered to a total dose of 45 Gy in 15 fractions in 10 patients (32%) who had total excision before radiotherapy and to a total dose of 54 Gy in 18 fractions in 21 patients (68%) who had subtotal excision or biopsy alone. Sex, age, type of surgery, tumor grade, Karnofsky performance status, time between surgery and initiation of radiotherapy, and total radiotherapy dose were analyzed as potential prognostic factors for survival using the univariate log-rank method. The median follow-up was 15 months (4-16 months). A total of 15 patients (48%) died of their illness; 16 patients (52%) were still alive at the last follow-up. The median survival time was 8 months. Actuarial 1-year overall survival was 40%. Type of surgery, timing of radiotherapy after surgery, and initial Karnofsky performance status were significant prognostic factors for survival. No grade 3-4 acute or late neurotoxicity was observed. The tolerance of patients to hypofractionated RT was not different from that for con- ventional radiotherapy. This treatment schedule can be used for patients with high-grade gliomas. Future investigations are needed to determine the optimal fractionation for high-grade gliomas.
Açıklama
[dc.description]
WOS: 000250069000004
Açıklama
[dc.description]
PubMed: 17917085
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
glioblastoma multiforme
Konu Başlıkları
[dc.subject]
anaplastic astrocytoma
Konu Başlıkları
[dc.subject]
hypofractionated radiotherapy
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
1357-0560
ISSN
[dc.identifier.issn]
1559-131X
İlk Sayfa Sayısı
[dc.identifier.startpage]
379
Son Sayfa Sayısı
[dc.identifier.endpage]
383
Dergi Adı
[dc.relation.journal]
MEDICAL ONCOLOGY
Dergi Sayısı
[dc.identifier.issue]
4
Dergi Cilt Bilgisi
[dc.identifier.volume]
24
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1007/s12032-007-0030-z
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/3660
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
25
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
09 Şubat 2024 12:31
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Tıklayınız
patients radiotherapy surgery survival high-grade gliomas factors fractions months follow-up median excision Karnofsky performance prognostic status between hypofractionated Actuarial Future investigations 1-year illness needed determine optimal fractionation overall schedule different tolerance ventional observed neurotoxicity treatment
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