Histological subgroups in classic kaposi sarcoma: A preliminary study

Background and Design: Kaposi sarcomas (KS) are vascular tumors with a low malignant potential which include overlapping infectious, immunologic, and neoplastic processes. Recently, many histological subtypes have been defined. Material and Method: In the present study, 151 cutaneous classic KS lesions in 56 patients were retrospectively evaluated with regard to histological subtypes. Determination of the subtypes was based on the predominant histopathological component in the lesion. We examined changes in epidermis and dermis along with intratumoral inflammatory response characteristics in the lesions. By defining histopathological variants of the cases, differences regarding subtypes were investigated. Results: Cases that bear the ordinary characteristics of KS and those that can not be classified otherwise, comprised 82..8% of the study group. Twenty-six cases showed consistency with the subtypes outlined in the literature in terms of their histopathological properties. The most common histological subtype was the lymphangiectatic variant in 7.3% of the cases. Bullous (2.6%), lymphangioma like (2.6%), intravascular (2%), and pyogenic granuloma like (2%) variants were less common. The most uncommon histological subtype was micronodular (0.6%) type. Lymphangiectatic, bullous, intravascular, and pyogenic granuloma like variants were frequently observed in the nodular stage of KSs. Lympangioma like changes were seen to be present in the early KS lesions. Lymphangiectatic type was oftenly associated with bullous component, whereas pyogenic granuloma like type demonstrated superficial ulceration and intense inflammatory response. Lymphangioma like and intravascular types exhibited a characteristic appearance, while other variants were accompanied by components belonging to different subtypes. Conclusion: In KS, histopathological subtypes can develop as a result of different pathological processes. The next stage of the current study, which is one of the largest case series in the literature, will be investigation of the clinical and prognostic characteristics of the variants. (Turkderm 2010; 44: 73-8)

Yazar Kandemir, Nilüfer Onak
Gün, Banu Doğan
Barut, Figen
Yurdakan, Gamze
Bahadır, Burak
Bektaş, Sibel
Gün, Mustafa
Keser, Sevinç Hallaç
Özdemir, Nagehan
Özdamar, Şükrü Oğuz
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/2725
Tek Biçim Adres 10.4274/turkderm.44.73
Konu Başlıkları Classic
kaposi sarcoma
histological subtypes
Koleksiyonlar Fakülteler
Tıp Fakültesi
Cerrahi Bilimler Bölümü
Makale Koleksiyonu (Cerrahi Bilimler Bölümü)
Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı TURKDERM-TURKISH ARCHIVES OF DERMATOLOGY AND VENEROLOGY
Dergi Cilt Bilgisi 44
Dergi Sayısı 2
Sayfalar 73 - 78
Yayın Yılı 2010
Eser Adı
[dc.title]
Histological subgroups in classic kaposi sarcoma: A preliminary study
Yazar
[dc.contributor.author]
Kandemir, Nilüfer Onak
Yazar
[dc.contributor.author]
Gün, Banu Doğan
Yazar
[dc.contributor.author]
Barut, Figen
Yazar
[dc.contributor.author]
Yurdakan, Gamze
Yazar
[dc.contributor.author]
Bahadır, Burak
Yazar
[dc.contributor.author]
Bektaş, Sibel
Yazar
[dc.contributor.author]
Gün, Mustafa
Yazar
[dc.contributor.author]
Keser, Sevinç Hallaç
Yazar
[dc.contributor.author]
Özdemir, Nagehan
Yazar
[dc.contributor.author]
Özdamar, Şükrü Oğuz
Yayın Yılı
[dc.date.issued]
2010
Yayıncı
[dc.publisher]
DERI ZUHREVI HASTALIKLAR DERNEGI
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Background and Design: Kaposi sarcomas (KS) are vascular tumors with a low malignant potential which include overlapping infectious, immunologic, and neoplastic processes. Recently, many histological subtypes have been defined. Material and Method: In the present study, 151 cutaneous classic KS lesions in 56 patients were retrospectively evaluated with regard to histological subtypes. Determination of the subtypes was based on the predominant histopathological component in the lesion. We examined changes in epidermis and dermis along with intratumoral inflammatory response characteristics in the lesions. By defining histopathological variants of the cases, differences regarding subtypes were investigated. Results: Cases that bear the ordinary characteristics of KS and those that can not be classified otherwise, comprised 82..8% of the study group. Twenty-six cases showed consistency with the subtypes outlined in the literature in terms of their histopathological properties. The most common histological subtype was the lymphangiectatic variant in 7.3% of the cases. Bullous (2.6%), lymphangioma like (2.6%), intravascular (2%), and pyogenic granuloma like (2%) variants were less common. The most uncommon histological subtype was micronodular (0.6%) type. Lymphangiectatic, bullous, intravascular, and pyogenic granuloma like variants were frequently observed in the nodular stage of KSs. Lympangioma like changes were seen to be present in the early KS lesions. Lymphangiectatic type was oftenly associated with bullous component, whereas pyogenic granuloma like type demonstrated superficial ulceration and intense inflammatory response. Lymphangioma like and intravascular types exhibited a characteristic appearance, while other variants were accompanied by components belonging to different subtypes. Conclusion: In KS, histopathological subtypes can develop as a result of different pathological processes. The next stage of the current study, which is one of the largest case series in the literature, will be investigation of the clinical and prognostic characteristics of the variants. (Turkderm 2010; 44: 73-8)
Açıklama
[dc.description]
WOS: 000279339600006
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
tur
Konu Başlıkları
[dc.subject]
Classic
Konu Başlıkları
[dc.subject]
kaposi sarcoma
Konu Başlıkları
[dc.subject]
histological subtypes
Künye
[dc.identifier.citation]
Kandemir, N. O., Gun, B. D., Barut, F., Yurdakan, G., Bahadir, B., Bektas, S., … Ozdamar, S. O. (2010). Histological subgroups in classic kaposi sarcoma: A preliminary study. Turkderm-Turkish Archives of Dermatology and Venerology, 44(2), 73-78. doi:10.4274/turkderm.44.73
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
1019-214X
ISSN
[dc.identifier.issn]
1308-6294
İlk Sayfa Sayısı
[dc.identifier.startpage]
73
Son Sayfa Sayısı
[dc.identifier.endpage]
78
Dergi Adı
[dc.relation.journal]
TURKDERM-TURKISH ARCHIVES OF DERMATOLOGY AND VENEROLOGY
Dergi Sayısı
[dc.identifier.issue]
2
Dergi Cilt Bilgisi
[dc.identifier.volume]
44
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.4274/turkderm.44.73
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2725
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subtypes variants histopathological histological pyogenic granuloma lesions intravascular characteristics literature common component changes inflammatory response bullous Lymphangiectatic subtype different processes present largest pathological micronodular current uncommon appearance result series lymphangioma investigation clinical prognostic Bullous (Turkderm
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