Comparison of the diagnostic results of bronchoalveolar lavage with synchronous transbronchial biopsies

Objective: Bronchoalveolar lavage performed during bronchoscopic examination is a type of cytologic sampling with great diagnostic significance. Its diagnostic value is enhanced when biopsy is unavailable and bronchoalveolar lavage is the unique sample. Determining the diagnostic accuracy of bronchoalveolar lavage by comparing it with the diagnostic yield of synchronous biopsies is an indicator of its effectiveness. Material and Methods: In this study, 435 bronchoalveolar lavage and 273 bronchoscopic biopsy specimens obtained from January 2003 to December 2005 in the Department of Pulmonary Diseases were retrospectively evaluated in the Department of Pathology, Faculty of Medicine, Zonguldak Karaelmas University. Results: Overall, 373 cases (85.8%) were diagnosed as benign and 12 cases (2.8%) were reported as malignant, while IS cases (4.1%) were suspected to be malignant; the remaining 32 cases (7.3%) were reported as inadequate. The numbers and percentages of benign, malignant, suspected malignant and inadequate diagnoses of the 273 bronchoalveolar lavage cases with synchronous transbronchial biopsies were 229 (83.9%), 12 (4.5%), 16 (5.8%), and 16 (5.8%), respectively. After suspected malignant and inadequate samples were excluded, coomparison of cytologic and histologic diagnoses revealed that the diagnostic accuracy of bronchoalveolar lavage cytology was 79.4% and 91.6% for benign and malignant diagnoses, respectively; the rate of false negativity was 20.5% and false positivity was 8.3%. Conclusion: While sampling errors seemed to be the primary reason for false negative and false positive diagnoses, the rate of false cytologic evaluation was lower. Considering the false negative diagnoses for cases without biopsy specimens, comparison of bronchoalveolar lavage diagnoses with synchronous biopsies may serve as a quality control programme, since this condition may significantly influence the clinical course.

Yazar Barut, Figen
Özdamar, Şükrü Oğuz
Bahadır, Burak
Gün, Banu Doğan
Bektaş, Sibel
Çolak, Sacide
Kuzey, Gamze Mocan
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/2283
Konu Başlıkları bronchoalveolar lavage
cytology
Koleksiyonlar Fakülteler
Tıp Fakültesi
Cerrahi Bilimler Bölümü
Makale Koleksiyonu (Cerrahi Bilimler Bölümü)
Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı TURKIYE KLINIKLERI TIP BILIMLERI DERGISI
Dergi Cilt Bilgisi 27
Dergi Sayısı 2
Sayfalar 179 - 183
Yayın Yılı 2007
Eser Adı
[dc.title]
Comparison of the diagnostic results of bronchoalveolar lavage with synchronous transbronchial biopsies
Yazar
[dc.contributor.author]
Barut, Figen
Yazar
[dc.contributor.author]
Özdamar, Şükrü Oğuz
Yazar
[dc.contributor.author]
Bahadır, Burak
Yazar
[dc.contributor.author]
Gün, Banu Doğan
Yazar
[dc.contributor.author]
Bektaş, Sibel
Yazar
[dc.contributor.author]
Çolak, Sacide
Yazar
[dc.contributor.author]
Kuzey, Gamze Mocan
Yayın Yılı
[dc.date.issued]
2007
Yayıncı
[dc.publisher]
ORTADOGU AD PRES & PUBL CO
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Objective: Bronchoalveolar lavage performed during bronchoscopic examination is a type of cytologic sampling with great diagnostic significance. Its diagnostic value is enhanced when biopsy is unavailable and bronchoalveolar lavage is the unique sample. Determining the diagnostic accuracy of bronchoalveolar lavage by comparing it with the diagnostic yield of synchronous biopsies is an indicator of its effectiveness. Material and Methods: In this study, 435 bronchoalveolar lavage and 273 bronchoscopic biopsy specimens obtained from January 2003 to December 2005 in the Department of Pulmonary Diseases were retrospectively evaluated in the Department of Pathology, Faculty of Medicine, Zonguldak Karaelmas University. Results: Overall, 373 cases (85.8%) were diagnosed as benign and 12 cases (2.8%) were reported as malignant, while IS cases (4.1%) were suspected to be malignant; the remaining 32 cases (7.3%) were reported as inadequate. The numbers and percentages of benign, malignant, suspected malignant and inadequate diagnoses of the 273 bronchoalveolar lavage cases with synchronous transbronchial biopsies were 229 (83.9%), 12 (4.5%), 16 (5.8%), and 16 (5.8%), respectively. After suspected malignant and inadequate samples were excluded, coomparison of cytologic and histologic diagnoses revealed that the diagnostic accuracy of bronchoalveolar lavage cytology was 79.4% and 91.6% for benign and malignant diagnoses, respectively; the rate of false negativity was 20.5% and false positivity was 8.3%. Conclusion: While sampling errors seemed to be the primary reason for false negative and false positive diagnoses, the rate of false cytologic evaluation was lower. Considering the false negative diagnoses for cases without biopsy specimens, comparison of bronchoalveolar lavage diagnoses with synchronous biopsies may serve as a quality control programme, since this condition may significantly influence the clinical course.
Açıklama
[dc.description]
WOS: 000254582300004
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
tur
Konu Başlıkları
[dc.subject]
bronchoalveolar lavage
Konu Başlıkları
[dc.subject]
cytology
Künye
[dc.identifier.citation]
Barut, F., Oezdamar, S. O., Bahadir, B., Guen, B. D., Bektas, S., Colak, S. ve Kuzey, G. M. (2007). Comparison of the diagnostic results of bronchoalveolar lavage with synchronous transbronchial biopsies. Turkiye Klinikleri Tip Bilimleri Dergisi, 27(2), 179-183.
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
1300-0292
İlk Sayfa Sayısı
[dc.identifier.startpage]
179
Son Sayfa Sayısı
[dc.identifier.endpage]
183
Dergi Adı
[dc.relation.journal]
TURKIYE KLINIKLERI TIP BILIMLERI DERGISI
Dergi Sayısı
[dc.identifier.issue]
2
Dergi Cilt Bilgisi
[dc.identifier.volume]
27
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2283
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
42
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
09 Şubat 2024 08:44
Google Kontrol
Tıklayınız
lavage diagnoses malignant bronchoalveolar diagnostic benign biopsies biopsy synchronous inadequate cytologic suspected respectively Department specimens accuracy negative reported bronchoscopic sampling percentages transbronchial cytology revealed histologic coomparison excluded samples course clinical influence significantly condition programme control
6698 sayılı Kişisel Verilerin Korunması Kanunu kapsamında yükümlülüklerimiz ve çerez politikamız hakkında bilgi sahibi olmak için alttaki bağlantıyı kullanabilirsiniz.

creativecommons
Bu site altında yer alan tüm kaynaklar Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.
Platforms