Traumatic neuromas: A histopa thologic and immunohistochemical study

Objective: Traumatic neuroma is an exuberant, probably nonneoplastic proliferation of a nerve occurring in response to injury or surgery. We studied six cases of traumatic neuroma with light microscopic, histochemical and immunohistochemical methods to assess the cellular compositions of these lesions. Material and Methods: Sections from the formalin-fixed parafin-embedded tissues were stained with hematoxylin-eosin, Gomori's trichrome, Verhoeff elastica-von Gieson, reticuline, and S-100 protein, Epithelial Membrane Antigen, CD34 and CD68. Results: All cases revealed large numbers of small and haphazardly arranged regenerating nerve fascicles within a densely collagenous and fibroblastic stroma. A focal chronic mononuclear cell inflammatory reaction was observed in three cases. In all cases, Gomori's trichrome revealed collagen. Axonal morphology was detected in nerve fibers histochemically by reticulin. In all cases, fascicles were stained diffusely with S-100 protein, and Epithelial Membrane Antigen showed a positive reaction in a thin band of cells surrounding the fascicles in three of the cases. CD34 positive cells were present in five cases. CD68 expressing cells were present in only in two specimens. Conclusion: In traumatic neuromas, specific staining of fascicles with S-100 protein, perineural cells reactive for Epithelial Membrane Antigen and the presence of CD34 positive cells may contribute to our understanding of their pathogenesis and differentiation of these lesions from mimickers.

Dergi Adı TURKIYE KLINIKLERI TIP BILIMLERI DERGISI
Dergi Cilt Bilgisi 27
Dergi Sayısı 1
Sayfalar 16 - 20
Yayın Yılı 2007
Eser Adı
[dc.title]
Traumatic neuromas: A histopa thologic and immunohistochemical study
Yazar
[dc.contributor.author]
Özdamar, Şükrü Oğuz
Yazar
[dc.contributor.author]
Gün, Banu Doğan
Yazar
[dc.contributor.author]
Barut, Figen
Yazar
[dc.contributor.author]
Bahadır, Burak
Yayın Yılı
[dc.date.issued]
2007
Yayıncı
[dc.publisher]
ORTADOGU AD PRES & PUBL CO
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Objective: Traumatic neuroma is an exuberant, probably nonneoplastic proliferation of a nerve occurring in response to injury or surgery. We studied six cases of traumatic neuroma with light microscopic, histochemical and immunohistochemical methods to assess the cellular compositions of these lesions. Material and Methods: Sections from the formalin-fixed parafin-embedded tissues were stained with hematoxylin-eosin, Gomori's trichrome, Verhoeff elastica-von Gieson, reticuline, and S-100 protein, Epithelial Membrane Antigen, CD34 and CD68. Results: All cases revealed large numbers of small and haphazardly arranged regenerating nerve fascicles within a densely collagenous and fibroblastic stroma. A focal chronic mononuclear cell inflammatory reaction was observed in three cases. In all cases, Gomori's trichrome revealed collagen. Axonal morphology was detected in nerve fibers histochemically by reticulin. In all cases, fascicles were stained diffusely with S-100 protein, and Epithelial Membrane Antigen showed a positive reaction in a thin band of cells surrounding the fascicles in three of the cases. CD34 positive cells were present in five cases. CD68 expressing cells were present in only in two specimens. Conclusion: In traumatic neuromas, specific staining of fascicles with S-100 protein, perineural cells reactive for Epithelial Membrane Antigen and the presence of CD34 positive cells may contribute to our understanding of their pathogenesis and differentiation of these lesions from mimickers.
Açıklama
[dc.description]
WOS: 000254120800004
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
tur
Konu Başlıkları
[dc.subject]
neuroma
Konu Başlıkları
[dc.subject]
Schwann cells
Konu Başlıkları
[dc.subject]
immunohistochemistry
Künye
[dc.identifier.citation]
Özdamar, Ş. O., Gün, B. D., Barut, F. ve Bahadir, B. (2007). Travmatik Nöromalar: Histopatolojik ve İmmünohistokimyasal Bir Çalışma. Turkiye Klinikleri Journal of Medical Sciences, 27(1), 16-20.
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
1300-0292
İlk Sayfa Sayısı
[dc.identifier.startpage]
16
Son Sayfa Sayısı
[dc.identifier.endpage]
20
Dergi Adı
[dc.relation.journal]
TURKIYE KLINIKLERI TIP BILIMLERI DERGISI
Dergi Sayısı
[dc.identifier.issue]
1
Dergi Cilt Bilgisi
[dc.identifier.volume]
27
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/3721
Tek Biçim Adres
[dc.identifier.uri]
https://www.turkiyeklinikleri.com/article/en-travmatik-noromalar-histopatolojik-ve-immunohistokimyasal-bir-calisma-47269.html
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
24
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
09 Şubat 2024 08:23
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Tıklayınız
fascicles positive protein Epithelial Membrane Antigen trichrome lesions present revealed stained reaction neuroma traumatic Gomori detected observed collagen fibers histochemically morphology inflammatory Axonal Objective reticulin staining mimickers differentiation pathogenesis understanding contribute presence reactive perineural specific
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