Effects of Ankaferd Blood Stopper® on Bone Regeneration in Rat Calvarial Defects

Objective: The influence of Ankaferd Blood Stopper (R) (ABS) was experimentally investigated on calvarial defects in rats. Material and Methods: Fourteen Wistar-albino rats equally divided into two groups, control group (G1) and drug group (G2), were included in the study. In G1, only right frontal craniectomy was performed. In G2, 0.5ml ABS was topically applied with a syringe after craniectomy. Surface areas of the defects were measured after four weeks, and comparative reconstruction images with were obtained, computed tomography (CT) as well. Blood samples were also collected to evaluate prothrombin time (PT), international normalized ratio (INR) and activated partial thromboplastin time (aPTT), and tissue samples were harvested for histologic examination. Results: Mean defect area in G1 (7.20 +/- 2.62 mm(2)) was significantly larger than that in G2 (1.83 +/- 1.65 mm(2)) (p<0.001). Mean PT, INR and aPTT values were not different between the two groups (p>0.05). Three dimensional (3D) CT analysis and histological examination revealed prominent osteogenesis in G2. Conclusion: We observed that surface area of the calvarial defects decreased significantly after ABS administration, and this observation was confirmed by 3D CT analysis and histology. Thus, ABS seems to have a potential of bone promoting effect; however, precise mechanisms underlying this osteogenetic activity still remain unexplained.

Yazar Gül, Şanser
Bahadır, Burak
Kalaycı, Murat
Ankaralı, Handan
Erdem, Oktay
Karakaya, Kemal
Açıkgöz, Bektaş
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/2479
Tek Biçim Adres 10.5336/medsci.2009-15288
Konu Başlıkları Bone regeneration
models, animal
osteogenesis
skull
Koleksiyonlar Fakülteler
Tıp Fakültesi
Cerrahi Bilimler Bölümü
Makale Koleksiyonu (Cerrahi Bilimler Bölümü)
Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı TURKIYE KLINIKLERI TIP BILIMLERI DERGISI
Dergi Cilt Bilgisi 31
Dergi Sayısı 2
Sayfalar 390 - 396
Yayın Yılı 2011
Eser Adı
[dc.title]
Effects of Ankaferd Blood Stopper® on Bone Regeneration in Rat Calvarial Defects
Yazar
[dc.contributor.author]
Gül, Şanser
Yazar
[dc.contributor.author]
Bahadır, Burak
Yazar
[dc.contributor.author]
Kalaycı, Murat
Yazar
[dc.contributor.author]
Ankaralı, Handan
Yazar
[dc.contributor.author]
Erdem, Oktay
Yazar
[dc.contributor.author]
Karakaya, Kemal
Yazar
[dc.contributor.author]
Açıkgöz, Bektaş
Yayın Yılı
[dc.date.issued]
2011
Yayıncı
[dc.publisher]
ORTADOGU AD PRES & PUBL CO
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Objective: The influence of Ankaferd Blood Stopper (R) (ABS) was experimentally investigated on calvarial defects in rats. Material and Methods: Fourteen Wistar-albino rats equally divided into two groups, control group (G1) and drug group (G2), were included in the study. In G1, only right frontal craniectomy was performed. In G2, 0.5ml ABS was topically applied with a syringe after craniectomy. Surface areas of the defects were measured after four weeks, and comparative reconstruction images with were obtained, computed tomography (CT) as well. Blood samples were also collected to evaluate prothrombin time (PT), international normalized ratio (INR) and activated partial thromboplastin time (aPTT), and tissue samples were harvested for histologic examination. Results: Mean defect area in G1 (7.20 +/- 2.62 mm(2)) was significantly larger than that in G2 (1.83 +/- 1.65 mm(2)) (p<0.001). Mean PT, INR and aPTT values were not different between the two groups (p>0.05). Three dimensional (3D) CT analysis and histological examination revealed prominent osteogenesis in G2. Conclusion: We observed that surface area of the calvarial defects decreased significantly after ABS administration, and this observation was confirmed by 3D CT analysis and histology. Thus, ABS seems to have a potential of bone promoting effect; however, precise mechanisms underlying this osteogenetic activity still remain unexplained.
Açıklama
[dc.description]
WOS: 000291330700017
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Bone regeneration
Konu Başlıkları
[dc.subject]
models, animal
Konu Başlıkları
[dc.subject]
osteogenesis
Konu Başlıkları
[dc.subject]
skull
Künye
[dc.identifier.citation]
Gül, Ş., Bahadir, B., Kalayci, M., Ankarali, H., Erdem, O., Karakaya, K. ve Açikgöz, B. (2011). Effects of ankaferd blood stopper® on bone regeneration in rat calvarial defects. Turkiye Klinikleri Journal of Medical Sciences, 31(2), 390-396. doi:10.5336/medsci.2009-15288
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
1300-0292
ISSN
[dc.identifier.issn]
2146-9040
İlk Sayfa Sayısı
[dc.identifier.startpage]
390
Son Sayfa Sayısı
[dc.identifier.endpage]
396
Dergi Adı
[dc.relation.journal]
TURKIYE KLINIKLERI TIP BILIMLERI DERGISI
Dergi Sayısı
[dc.identifier.issue]
2
Dergi Cilt Bilgisi
[dc.identifier.volume]
31
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.5336/medsci.2009-15288
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2479
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
126
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
18 Mayıs 2024 22:29
Google Kontrol
Tıklayınız
defects samples craniectomy analysis groups significantly calvarial examination mm(2)) between different values larger Objective dimensional unexplained remain activity osteogenetic underlying mechanisms precise however effect promoting potential histology confirmed observation administration decreased surface observed Conclusion osteogenesis
6698 sayılı Kişisel Verilerin Korunması Kanunu kapsamında yükümlülüklerimiz ve çerez politikamız hakkında bilgi sahibi olmak için alttaki bağlantıyı kullanabilirsiniz.

creativecommons
Bu site altında yer alan tüm kaynaklar Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.
Platforms