The relation between gleason score, and nuclear size and shape factors in prostatic adenocarcinoma

Aim: The aim of this study was to assess the size and shape characteristics of prostatic adenocarcinoma cell nuclei using a computer-assisted analysis system, and to compare the results with the Gleason score. Materials and Methods: Morphometric nuclear parameters, such as roundness factor, form ellipse, area, length, and perimeter, were evaluated based on specimen slides of 130 prostatic adenocarcinoma cases (77% needle biopsies and 23% prostatectomy specimens) using a computerized image analysis system. Correlation analysis between Gleason score and morphometric results was performed. Results: The Gleason score was correlated with mean nuclear area (r = 0.516, P = 0.01), mean nuclear length (r = 0.298, P = 0.01), and mean nuclear perimeter (r = 0.303, P = 0.01) for all specimens. In the needle biopsy group the Gleason score was correlated with mean nuclear area (r = 0.522, P = 0.01), mean nuclear length (r = 0.398, P = 0.01), and mean nuclear perimeter (r = 0.432, P = 0.01), whereas in the prostatectomy group the Gleason score was correlated only with mean nuclear area (? = 0.619, P = 0.01) and mean nuclear roundness factor (? = -0.425, P = 0.05). Conclusions: Nuclear size and shape factors, especially mean nuclear area, were concordant with the Gleason score. Nuclear size and shape assessment may aid in the evaluation of the pathological status of prostatic adenocarcinoma. © TÜBİTAK.

Dergi Adı Turkish Journal of Medical Sciences
Dergi Cilt Bilgisi 39
Dergi Sayısı 3
Sayfalar 381 - 387
Yayın Yılı 2009
Eser Adı
[dc.title]
The relation between gleason score, and nuclear size and shape factors in prostatic adenocarcinoma
Yazar
[dc.contributor.author]
Bektaş, Sibel
Yazar
[dc.contributor.author]
Bahadır, Burak
Yazar
[dc.contributor.author]
Doğan Gün, Banu
Yazar
[dc.contributor.author]
Kertiş, Gürkan
Yazar
[dc.contributor.author]
Özdamar, Şükrü Oğuz
Yayın Yılı
[dc.date.issued]
2009
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Aim: The aim of this study was to assess the size and shape characteristics of prostatic adenocarcinoma cell nuclei using a computer-assisted analysis system, and to compare the results with the Gleason score. Materials and Methods: Morphometric nuclear parameters, such as roundness factor, form ellipse, area, length, and perimeter, were evaluated based on specimen slides of 130 prostatic adenocarcinoma cases (77% needle biopsies and 23% prostatectomy specimens) using a computerized image analysis system. Correlation analysis between Gleason score and morphometric results was performed. Results: The Gleason score was correlated with mean nuclear area (r = 0.516, P = 0.01), mean nuclear length (r = 0.298, P = 0.01), and mean nuclear perimeter (r = 0.303, P = 0.01) for all specimens. In the needle biopsy group the Gleason score was correlated with mean nuclear area (r = 0.522, P = 0.01), mean nuclear length (r = 0.398, P = 0.01), and mean nuclear perimeter (r = 0.432, P = 0.01), whereas in the prostatectomy group the Gleason score was correlated only with mean nuclear area (? = 0.619, P = 0.01) and mean nuclear roundness factor (? = -0.425, P = 0.05). Conclusions: Nuclear size and shape factors, especially mean nuclear area, were concordant with the Gleason score. Nuclear size and shape assessment may aid in the evaluation of the pathological status of prostatic adenocarcinoma. © TÜBİTAK.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Gleason score
Konu Başlıkları
[dc.subject]
Nuclear shape
Konu Başlıkları
[dc.subject]
Nuclear size
Konu Başlıkları
[dc.subject]
Prostatic adenocarcinoma
Künye
[dc.identifier.citation]
Bektas, S., Bahadir, B., Gun, B. D., Kertis, G. ve Ozdamar, S. O. (2009). The relation between gleason score, and nuclear size and shape factors in prostatic adenocarcinoma. Turkish Journal of Medical Sciences, 39(3), 381-387. doi:10.3906/sag-0711-31
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
1300-0144
İlk Sayfa Sayısı
[dc.identifier.startpage]
381
Son Sayfa Sayısı
[dc.identifier.endpage]
387
Dergi Adı
[dc.relation.journal]
Turkish Journal of Medical Sciences
Dergi Sayısı
[dc.identifier.issue]
3
Dergi Cilt Bilgisi
[dc.identifier.volume]
39
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.3906/sag-0711-31
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/8216
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nuclear Gleason perimeter length analysis prostatic adenocarcinoma correlated factor prostatectomy roundness needle Nuclear system results status biopsy TÜBİTAK specimens pathological evaluation Conclusions whereas assessment concordant especially factors Results computer-assisted parameters Morphometric Methods Materials compare nuclei
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