Does Sericin, as a Novel Pleurodesis Agent, Have Higher Effectiveness Compared to Talcum Powder, Doxycycline, and Silver Nitrate Pleurodesis?

Introduction: The usefulness of sericin as pleurodesis agent has previously been described. Present study aims to compare sericin pleurodesis regarding success, effectiveness, tolerability, and side-effects. Methods: Adult, 12-week-old Wistar-albino rats (n = 60), divided to five groups as sericin, talcum-powder, doxycycline, silver-nitrate and control. Agents were administrated through left thoracotomy, rats sacrificed twelve-days after. Results: Highest ratio of collagen fibers was observed in sericin group, and the intensity was higher than talcum-powder group (p < 0.05). Compared to silver nitrate, sericin group displayed better mesothelial reaction, and multi-layer mesothelium was also better (p < 0.05). Foreign body reaction and emphysema were less frequent in sericin group (p < 0.05). The presence of biological tissue in parenchyma was less prominent in sericin group (p < 0.05). Foreign body reaction on thoracic wall was less common in sericin group (p < 0.05). Presence of biological tissue glue in thoracic wall was less prominent in sericin group (p < 0.05). Glomerular degeneration was lower in sericin group compared to the silver nitrate group (p < 0.05), and tubular degeneration was less common in sericin group than talcum group (p < 0.05). Pericarditis was less common in sericin group compared to the other groups (p < 0.05). Conclusion: As an intrinsic, natural glue protein, sericin protects the lung parenchyma and tissues, and its glue-like characteristics enable pleurodesis. The success of sericin in pleurodesis was demonstrated in the present study based on investigations of the pleurae. Being cost-effective and better tolerated agent associated with a low potential of side effects, sericin is more effective, less expensive and provides more lung parenchyma protection. (C) 2018 SEPAR. Published by Elsevier Espana, S.L.U. All rights reserved.

Yazar Yazicioglu, Alkin
Uysal, Serkan
Sahinoglu, Tuba
Subasi, Mahmut
Demirag, Funda
Yekeler, Erdal
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/2415
Tek Biçim Adres 10.1016/j.arbres.2018.10.003
Konu Başlıkları Sericin
Talcum powder
Doxycycline
Silver nitrate
Pleurodesis
Fibrosis
Pleura
Parenchyma
Cost-effective
Side effect
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı ARCHIVOS DE BRONCONEUMOLOGIA
Dergi Cilt Bilgisi 55
Dergi Sayısı 7
Sayfalar 357 - 367
Yayın Yılı 2019
Eser Adı
[dc.title]
Does Sericin, as a Novel Pleurodesis Agent, Have Higher Effectiveness Compared to Talcum Powder, Doxycycline, and Silver Nitrate Pleurodesis?
Yazar
[dc.contributor.author]
Yazicioglu, Alkin
Yazar
[dc.contributor.author]
Uysal, Serkan
Yazar
[dc.contributor.author]
Sahinoglu, Tuba
Yazar
[dc.contributor.author]
Subasi, Mahmut
Yazar
[dc.contributor.author]
Demirag, Funda
Yazar
[dc.contributor.author]
Yekeler, Erdal
Yayın Yılı
[dc.date.issued]
2019
Yayıncı
[dc.publisher]
ELSEVIER ESPANA SLU
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Introduction: The usefulness of sericin as pleurodesis agent has previously been described. Present study aims to compare sericin pleurodesis regarding success, effectiveness, tolerability, and side-effects. Methods: Adult, 12-week-old Wistar-albino rats (n = 60), divided to five groups as sericin, talcum-powder, doxycycline, silver-nitrate and control. Agents were administrated through left thoracotomy, rats sacrificed twelve-days after. Results: Highest ratio of collagen fibers was observed in sericin group, and the intensity was higher than talcum-powder group (p < 0.05). Compared to silver nitrate, sericin group displayed better mesothelial reaction, and multi-layer mesothelium was also better (p < 0.05). Foreign body reaction and emphysema were less frequent in sericin group (p < 0.05). The presence of biological tissue in parenchyma was less prominent in sericin group (p < 0.05). Foreign body reaction on thoracic wall was less common in sericin group (p < 0.05). Presence of biological tissue glue in thoracic wall was less prominent in sericin group (p < 0.05). Glomerular degeneration was lower in sericin group compared to the silver nitrate group (p < 0.05), and tubular degeneration was less common in sericin group than talcum group (p < 0.05). Pericarditis was less common in sericin group compared to the other groups (p < 0.05). Conclusion: As an intrinsic, natural glue protein, sericin protects the lung parenchyma and tissues, and its glue-like characteristics enable pleurodesis. The success of sericin in pleurodesis was demonstrated in the present study based on investigations of the pleurae. Being cost-effective and better tolerated agent associated with a low potential of side effects, sericin is more effective, less expensive and provides more lung parenchyma protection. (C) 2018 SEPAR. Published by Elsevier Espana, S.L.U. All rights reserved.
Açıklama
[dc.description]
WOS: 000473381900007
Açıklama
[dc.description]
PubMed: 30473265
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Sericin
Konu Başlıkları
[dc.subject]
Talcum powder
Konu Başlıkları
[dc.subject]
Doxycycline
Konu Başlıkları
[dc.subject]
Silver nitrate
Konu Başlıkları
[dc.subject]
Pleurodesis
Konu Başlıkları
[dc.subject]
Fibrosis
Konu Başlıkları
[dc.subject]
Pleura
Konu Başlıkları
[dc.subject]
Parenchyma
Konu Başlıkları
[dc.subject]
Cost-effective
Konu Başlıkları
[dc.subject]
Side effect
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0300-2896
ISSN
[dc.identifier.issn]
1579-2129
İlk Sayfa Sayısı
[dc.identifier.startpage]
357
Son Sayfa Sayısı
[dc.identifier.endpage]
367
Dergi Adı
[dc.relation.journal]
ARCHIVOS DE BRONCONEUMOLOGIA
Dergi Sayısı
[dc.identifier.issue]
7
Dergi Cilt Bilgisi
[dc.identifier.volume]
55
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1016/j.arbres.2018.10.003
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2415
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
26
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
09 Şubat 2024 12:19
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Tıklayınız
sericin pleurodesis better reaction common parenchyma compared nitrate silver talcum-powder groups Foreign prominent degeneration thoracic success tissue biological protein protects natural intrinsic Pericarditis talcum Conclusion tissues Introduction provides protection Published Elsevier effective Espana rights reserved
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