The effects of adrenomedullin in traumatic brain injury

Traumatic brain injury (TBI) is a common cause of death and disability throughout the world. A multifunctional peptide adrenomedullin (AM) has protective effects in the central nervous system. We evaluated AM in an animal model as a therapeutic agent that reduces brain damage after traumatic brain injury. A total of 36 rats was divided into 3 groups as sham, head trauma plus intraperitoneal (ip) saline, and head trauma plus adrenomedullin ip. The diffuse brain injury model of Marmarou et al. was used. Blood samples were taken from all groups at the 1st, 6th and 24th hours for analysis of TNF-alpha (tumor necrosis factor-alpha), IL-1 beta (interleukin-1 beta) and IL-6 (interleukin-6) levels. At the end of the study (at the 24th hour) a neurological examination was performed and half of the rats were decapitated to obtain blood and tissue samples, the other half were perfused transcardiacally for studying the histopathology of the brain tissue. There were no statistically significant changes in plasma levels of IL-1 beta, IL-6 and TNF-alpha relative to the sham group. Also, changes in tissue levels of malonedialdehyde, myeloperoxidase and glutathione were not statistically significant. However, neurological scores and histopathological examinations revealed healing. AM individually exerts neuroprotective effects in animal models of acute brain injury. But the mechanisms of action remain to be assessed. (C) 2013 Elsevier Inc. All rights reserved.

Yazar Demir, Hasan
Onur, Ozge E.
Denizbasi, Arzu
Akoglu, Haldun
Eroglu, Serkan E.
Ozpolat, Cigdem
Akoglu, Ebru
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/3544
Tek Biçim Adres 10.1016/j.peptides.2013.02.018
Konu Başlıkları Adrenomedullin
Traumatic brain injury
Myeloperoxidase
MDA
GSH
IL-6
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı PEPTIDES
Dergi Cilt Bilgisi 43
Sayfalar 27 - 31
Yayın Yılı 2013
Eser Adı
[dc.title]
The effects of adrenomedullin in traumatic brain injury
Yazar
[dc.contributor.author]
Demir, Hasan
Yazar
[dc.contributor.author]
Onur, Ozge E.
Yazar
[dc.contributor.author]
Denizbasi, Arzu
Yazar
[dc.contributor.author]
Akoglu, Haldun
Yazar
[dc.contributor.author]
Eroglu, Serkan E.
Yazar
[dc.contributor.author]
Ozpolat, Cigdem
Yazar
[dc.contributor.author]
Akoglu, Ebru
Yayın Yılı
[dc.date.issued]
2013
Yayıncı
[dc.publisher]
ELSEVIER SCIENCE INC
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Traumatic brain injury (TBI) is a common cause of death and disability throughout the world. A multifunctional peptide adrenomedullin (AM) has protective effects in the central nervous system. We evaluated AM in an animal model as a therapeutic agent that reduces brain damage after traumatic brain injury. A total of 36 rats was divided into 3 groups as sham, head trauma plus intraperitoneal (ip) saline, and head trauma plus adrenomedullin ip. The diffuse brain injury model of Marmarou et al. was used. Blood samples were taken from all groups at the 1st, 6th and 24th hours for analysis of TNF-alpha (tumor necrosis factor-alpha), IL-1 beta (interleukin-1 beta) and IL-6 (interleukin-6) levels. At the end of the study (at the 24th hour) a neurological examination was performed and half of the rats were decapitated to obtain blood and tissue samples, the other half were perfused transcardiacally for studying the histopathology of the brain tissue. There were no statistically significant changes in plasma levels of IL-1 beta, IL-6 and TNF-alpha relative to the sham group. Also, changes in tissue levels of malonedialdehyde, myeloperoxidase and glutathione were not statistically significant. However, neurological scores and histopathological examinations revealed healing. AM individually exerts neuroprotective effects in animal models of acute brain injury. But the mechanisms of action remain to be assessed. (C) 2013 Elsevier Inc. All rights reserved.
Açıklama
[dc.description]
WOS: 000320144300005
Açıklama
[dc.description]
PubMed: 23474144
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Adrenomedullin
Konu Başlıkları
[dc.subject]
Traumatic brain injury
Konu Başlıkları
[dc.subject]
Myeloperoxidase
Konu Başlıkları
[dc.subject]
MDA
Konu Başlıkları
[dc.subject]
GSH
Konu Başlıkları
[dc.subject]
IL-6
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0196-9781
Sponsor YAYINCI
[dc.description.sponsorship]
BAPKO (Marmara University, Scientific Research Board)Marmara University
Sponsor YAYINCI
[dc.description.sponsorship]
Special thanks to BAPKO (Marmara University, Scientific Research Board) for funding. Special thanks also to R. W. Guillery, PhD for English addition.
İlk Sayfa Sayısı
[dc.identifier.startpage]
27
Son Sayfa Sayısı
[dc.identifier.endpage]
31
Dergi Adı
[dc.relation.journal]
PEPTIDES
Dergi Cilt Bilgisi
[dc.identifier.volume]
43
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1016/j.peptides.2013.02.018
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/3544
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
15
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
09 Şubat 2024 22:37
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injury tissue levels statistically changes trauma samples significant animal groups effects adrenomedullin TNF-alpha neurological decapitated studying examination histopathology obtain transcardiacally perfused performed Traumatic malonedialdehyde plasma reserved rights Elsevier assessed remain action mechanisms models relative neuroprotective
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