Simultaneous determination of selected endocrine disrupter compounds in wastewater samples in ultra trace levels using HPLC-ES-MS/MS

An analytical procedure for the simultaneous determination of six selected endocrine disrupter compounds (EDCs: diltiazem, progesterone, benzyl butyl phthalate (BBP), estrone, carbamazepine (Cbz), acetaminophen) was developed by liquid chromatography electrospray ionization tandem mass spectrometry (HPLC-ES-MS/MS). All of the parameters for HPLC and ES-MS/MS systems including mobile phase composition, flow rate, and sample injection volume were optimized to obtain not only the best separation of species interested but also low detection limits. Reverse phase chromatography coupled to ES-MS/MS was used for the separation and detection of EDCs. Formic acid (0.10% ) and 5.0 mM ammonium formate were selected as mobile phase composition in gradient elution. Detection limits for diltiazem, progesterone, BBP, estrone, Cbz, and acetaminophen were found to be 0.13, 0.12, 0.04, 0.13, 0.12, and 0.05 ng/mL, respectively. Influent and effluents from three different wastewater treatment plants located in Ankara, i.e., rotating flat-sheet membrane unit, pilot type flat-sheet membrane unit located at METU Campus and samples from Ankara central wastewater treatment plant were analyzed for their EDCs contents under the optimum conditions.

Yazar Komesli, Okan Tarik
Bakirdere, Sezgin
Bayoren, Ceren
Gokcay, Celal Ferdi
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/3331
Tek Biçim Adres 10.1007/s10661-011-2334-x
Konu Başlıkları Endocrine disrupter compounds
HPLC-ES-MS/MS
Wastewater
Ultra trace
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı ENVIRONMENTAL MONITORING AND ASSESSMENT
Dergi Cilt Bilgisi 184
Dergi Sayısı 8
Sayfalar 5215 - 5224
Yayın Yılı 2012
Eser Adı
[dc.title]
Simultaneous determination of selected endocrine disrupter compounds in wastewater samples in ultra trace levels using HPLC-ES-MS/MS
Yazar
[dc.contributor.author]
Komesli, Okan Tarik
Yazar
[dc.contributor.author]
Bakirdere, Sezgin
Yazar
[dc.contributor.author]
Bayoren, Ceren
Yazar
[dc.contributor.author]
Gokcay, Celal Ferdi
Yayın Yılı
[dc.date.issued]
2012
Yayıncı
[dc.publisher]
SPRINGER
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
An analytical procedure for the simultaneous determination of six selected endocrine disrupter compounds (EDCs: diltiazem, progesterone, benzyl butyl phthalate (BBP), estrone, carbamazepine (Cbz), acetaminophen) was developed by liquid chromatography electrospray ionization tandem mass spectrometry (HPLC-ES-MS/MS). All of the parameters for HPLC and ES-MS/MS systems including mobile phase composition, flow rate, and sample injection volume were optimized to obtain not only the best separation of species interested but also low detection limits. Reverse phase chromatography coupled to ES-MS/MS was used for the separation and detection of EDCs. Formic acid (0.10% ) and 5.0 mM ammonium formate were selected as mobile phase composition in gradient elution. Detection limits for diltiazem, progesterone, BBP, estrone, Cbz, and acetaminophen were found to be 0.13, 0.12, 0.04, 0.13, 0.12, and 0.05 ng/mL, respectively. Influent and effluents from three different wastewater treatment plants located in Ankara, i.e., rotating flat-sheet membrane unit, pilot type flat-sheet membrane unit located at METU Campus and samples from Ankara central wastewater treatment plant were analyzed for their EDCs contents under the optimum conditions.
Açıklama
[dc.description]
WOS: 000305979700045
Açıklama
[dc.description]
PubMed: 21912869
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Endocrine disrupter compounds
Konu Başlıkları
[dc.subject]
HPLC-ES-MS/MS
Konu Başlıkları
[dc.subject]
Wastewater
Konu Başlıkları
[dc.subject]
Ultra trace
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0167-6369
ISSN
[dc.identifier.issn]
1573-2959
Sponsor YAYINCI
[dc.description.sponsorship]
Turkish Scientific and Technical Researches Institution (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [108Y272]; METU-TechnopolisMiddle East Technical University
Sponsor YAYINCI
[dc.description.sponsorship]
This study was supported by Turkish Scientific and Technical Researches Institution (TUBITAK) Project No 108Y272 and METU-Technopolis.
İlk Sayfa Sayısı
[dc.identifier.startpage]
5215
Son Sayfa Sayısı
[dc.identifier.endpage]
5224
Dergi Adı
[dc.relation.journal]
ENVIRONMENTAL MONITORING AND ASSESSMENT
Dergi Sayısı
[dc.identifier.issue]
8
Dergi Cilt Bilgisi
[dc.identifier.volume]
184
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1007/s10661-011-2334-x
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/3331
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
139
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
05 Haziran 2024 23:21
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Tıklayınız
Ankara located treatment ES-MS/MS mobile composition flat-sheet separation detection limits chromatography wastewater membrane diltiazem progesterone estrone selected Detection acetaminophen gradient elution analyzed contents optimum formate conditions ammonium rotating plants different central Campus effluents samples Influent
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