Neural cell adhesion molecule-180 expression as a prognostic criterion in colorectal carcinoma: Feasible or not?

AIM: To evaluate the frequency of neural cell adhesion molecule (NCAM)-180 expression in fresh tumor tissue samples and to discuss the prognostic value of NCAM-180 in routine clinical practice. METHODS: Twenty-six patients (16 men, 10 women) with colorectal cancer were included in the study. Fresh tumor tissue samples and macroscopically healthy proximal margins of each specimen were subjected to flow-cytometric analysis for NCAM-180 expression. RESULTS: Flow-cytometric analysis determined NCAM-180 expression in whole tissue samples of macroscopically healthy colorectal tissues. However, NCAM-180 expression was positive in only one case (3.84%) with well-differentiated Stage II disease who experienced no active disease at 30 months follow-up. CONCLUSION: As a consequence of the limited number of cases in our series, it might not be possible to make a generalisation, nevertheless the routine use of NCAM-180 expression as a prognostic marker for colorectal carcinoma seems to be unfeasible and not cost-effective in clinical practice due to its very low incidence. (C) 2007 WJG. All rights reserved.

Yazar Tascilar, Oge
Cakmak, Gueleniz Karadeniz
Tekin, Ishak Ozel
Emre, Ali Ugur
Ucan, Bulent Hamdi
Irkorucu, Oktay
Karakaya, Kemal
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/2989
Tek Biçim Adres 10.3748/wjg.v13.i41.5476
Konu Başlıkları neural cell adhesion molecule-180
colorectal cancer
prognosis
flow-cytometry
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı WORLD JOURNAL OF GASTROENTEROLOGY
Dergi Cilt Bilgisi 13
Dergi Sayısı 41
Sayfalar 5476 - 5480
Yayın Yılı 2007
Eser Adı
[dc.title]
Neural cell adhesion molecule-180 expression as a prognostic criterion in colorectal carcinoma: Feasible or not?
Yazar
[dc.contributor.author]
Tascilar, Oge
Yazar
[dc.contributor.author]
Cakmak, Gueleniz Karadeniz
Yazar
[dc.contributor.author]
Tekin, Ishak Ozel
Yazar
[dc.contributor.author]
Emre, Ali Ugur
Yazar
[dc.contributor.author]
Ucan, Bulent Hamdi
Yazar
[dc.contributor.author]
Irkorucu, Oktay
Yazar
[dc.contributor.author]
Karakaya, Kemal
Yayın Yılı
[dc.date.issued]
2007
Yayıncı
[dc.publisher]
BAISHIDENG PUBLISHING GROUP INC
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
AIM: To evaluate the frequency of neural cell adhesion molecule (NCAM)-180 expression in fresh tumor tissue samples and to discuss the prognostic value of NCAM-180 in routine clinical practice. METHODS: Twenty-six patients (16 men, 10 women) with colorectal cancer were included in the study. Fresh tumor tissue samples and macroscopically healthy proximal margins of each specimen were subjected to flow-cytometric analysis for NCAM-180 expression. RESULTS: Flow-cytometric analysis determined NCAM-180 expression in whole tissue samples of macroscopically healthy colorectal tissues. However, NCAM-180 expression was positive in only one case (3.84%) with well-differentiated Stage II disease who experienced no active disease at 30 months follow-up. CONCLUSION: As a consequence of the limited number of cases in our series, it might not be possible to make a generalisation, nevertheless the routine use of NCAM-180 expression as a prognostic marker for colorectal carcinoma seems to be unfeasible and not cost-effective in clinical practice due to its very low incidence. (C) 2007 WJG. All rights reserved.
Açıklama
[dc.description]
WOS: 000249901500008
Açıklama
[dc.description]
PubMed: 17907291
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
neural cell adhesion molecule-180
Konu Başlıkları
[dc.subject]
colorectal cancer
Konu Başlıkları
[dc.subject]
prognosis
Konu Başlıkları
[dc.subject]
flow-cytometry
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
1007-9327
ISSN
[dc.identifier.issn]
2219-2840
İlk Sayfa Sayısı
[dc.identifier.startpage]
5476
Son Sayfa Sayısı
[dc.identifier.endpage]
5480
Dergi Adı
[dc.relation.journal]
WORLD JOURNAL OF GASTROENTEROLOGY
Dergi Sayısı
[dc.identifier.issue]
41
Dergi Cilt Bilgisi
[dc.identifier.volume]
13
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.3748/wjg.v13.i41.5476
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2989
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
14
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
08 Şubat 2024 09:12
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Tıklayınız
NCAM-180 expression colorectal samples tissue clinical practice analysis disease macroscopically healthy routine prognostic experienced series active months follow-up CONCLUSION number limited consequence possible reserved rights incidence cost-effective unfeasible carcinoma marker nevertheless generalisation However discuss women)
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