The histology and the proapoptotic control in the ipsilateral and the contralateral testes following unilateral vasectomy

Objective: The aim of this study was to enlighten both the testicular histology and the genetic aspects of the apoptotic process. Thus an experimental study was designed with a model of unilateral vasectomy. Methods: Twenty-two adult male rats were used and 4 main groups were formed. The first (A), the second (B), the third (C), and the fourth group (D) consisted of 4, 4, 4 and 10 rats respectively. Rats in group A had sham operation while rats in other groups (B, C, D) underwent left vasectomy operation including binding of ductus deferens with a 3/0 silk and cutting a minimum of 1 cm part while preserving the vascular structure under 9x magnification. Rats undergoing unilateral vasectomy were sacrificed at the 1st, 2nd and 8th weeks and their testicular structure and proapoptotic gene proteins were compared with that of the control group undergoing sham operation. Results: We found that vasectomy gradually caused destruction and both ipsilateral and contralateral testicles were affected showing initial apoptosis. Conclusion: The procedure causes destruction in the testicular structure by causing bilateral intratubular germ cell necrosis, unilateral obstruction, increase in the tubular pressure and processes that are aggravated by some probable autoimmune reactions.

Yazar Hazar, Aydin Ismet
Cakiroglu, Basri
Sakalli, Ertan
Balci, Mustafa Bahadir Can
Eyyupoglu, Erkan
Tas, Tuncay
Sinanoglu, Orhun
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/3595
Tek Biçim Adres 10.4081/aiua.2015.3.198
Konu Başlıkları Testis
Spermatogenesis
Vasectomy
Apoptosis
BCL-2 protein
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı ARCHIVIO ITALIANO DI UROLOGIA E ANDROLOGIA
Dergi Cilt Bilgisi 87
Dergi Sayısı 3
Sayfalar 198 - 203
Yayın Yılı 2015
Eser Adı
[dc.title]
The histology and the proapoptotic control in the ipsilateral and the contralateral testes following unilateral vasectomy
Yazar
[dc.contributor.author]
Hazar, Aydin Ismet
Yazar
[dc.contributor.author]
Cakiroglu, Basri
Yazar
[dc.contributor.author]
Sakalli, Ertan
Yazar
[dc.contributor.author]
Balci, Mustafa Bahadir Can
Yazar
[dc.contributor.author]
Eyyupoglu, Erkan
Yazar
[dc.contributor.author]
Tas, Tuncay
Yazar
[dc.contributor.author]
Sinanoglu, Orhun
Yayın Yılı
[dc.date.issued]
2015
Yayıncı
[dc.publisher]
PAGEPRESS PUBL
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Objective: The aim of this study was to enlighten both the testicular histology and the genetic aspects of the apoptotic process. Thus an experimental study was designed with a model of unilateral vasectomy. Methods: Twenty-two adult male rats were used and 4 main groups were formed. The first (A), the second (B), the third (C), and the fourth group (D) consisted of 4, 4, 4 and 10 rats respectively. Rats in group A had sham operation while rats in other groups (B, C, D) underwent left vasectomy operation including binding of ductus deferens with a 3/0 silk and cutting a minimum of 1 cm part while preserving the vascular structure under 9x magnification. Rats undergoing unilateral vasectomy were sacrificed at the 1st, 2nd and 8th weeks and their testicular structure and proapoptotic gene proteins were compared with that of the control group undergoing sham operation. Results: We found that vasectomy gradually caused destruction and both ipsilateral and contralateral testicles were affected showing initial apoptosis. Conclusion: The procedure causes destruction in the testicular structure by causing bilateral intratubular germ cell necrosis, unilateral obstruction, increase in the tubular pressure and processes that are aggravated by some probable autoimmune reactions.
Açıklama
[dc.description]
WOS: 000440260800004
Açıklama
[dc.description]
PubMed: 26428640
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Testis
Konu Başlıkları
[dc.subject]
Spermatogenesis
Konu Başlıkları
[dc.subject]
Vasectomy
Konu Başlıkları
[dc.subject]
Apoptosis
Konu Başlıkları
[dc.subject]
BCL-2 protein
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
1124-3562
ISSN
[dc.identifier.issn]
2282-4197
Sponsor YAYINCI
[dc.description.sponsorship]
Pathology Laboratory, Taksim Training and Research Hospital
Sponsor YAYINCI
[dc.description.sponsorship]
We thank Pathology Laboratory, Taksim Training and Research Hospital for laboratory facilities, technical assistance and financial aid.
İlk Sayfa Sayısı
[dc.identifier.startpage]
198
Son Sayfa Sayısı
[dc.identifier.endpage]
203
Dergi Adı
[dc.relation.journal]
ARCHIVIO ITALIANO DI UROLOGIA E ANDROLOGIA
Dergi Sayısı
[dc.identifier.issue]
3
Dergi Cilt Bilgisi
[dc.identifier.volume]
87
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.4081/aiua.2015.3.198
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/3595
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
12
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
17 Aralık 2023 05:24
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Tıklayınız
vasectomy structure operation unilateral testicular undergoing groups destruction Results magnification gradually control sacrificed compared proteins proapoptotic Objective Conclusion caused necrosis reactions autoimmune probable aggravated processes pressure tubular increase obstruction ipsilateral intratubular bilateral causing causes procedure
6698 sayılı Kişisel Verilerin Korunması Kanunu kapsamında yükümlülüklerimiz ve çerez politikamız hakkında bilgi sahibi olmak için alttaki bağlantıyı kullanabilirsiniz.

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