T2-weighted MRI in Parkinson's disease; Substantia-nigra pars compacta hypointensity correlates with the clinical scores

Background: Iron accumulation in substantia nigra. pars compacta (SNpc) and related intensity and volumetric changes in patients with idiopathic Parkinson's disease (PD) has been reported previously. There are only a few studies evaluating the relation between neuroradiological findings and clinical scores, with contradictory results. Alms: In this study we aimed to measure the iron-rich brain areas of PD patients and healthy subjects with T2-weighted magnetic resonance imaging (MRI) and to evaluate the relation between the clinical scores of PD patients and these imaging results. Methods and Materials: T2-weighted MRI findings were studied in 20 patients with PD and 16 healthy controls. The width of SNpc, putamen volume, and the intensity of the basal ganglia were measured. Unified Parkinson's Disease Rating Scale (UPDRS) was used for evaluating the clinical status. Statistical Analyses: Mann Whitney U test for group comparisons, Wilcoxon sign rank test for comparisons within the patient group, and Spearman's rank correlation coefficient for analyses of correlations were used. Results: Mean SNpc and dentate nucleus intensities were lower in PD patients than healthy subjects. Mean SNpc width and putamen volumes were lower in patients. Decrease in the intensity of mean SNpc correlated with high UPDRS and rigidity scores. Conclusion: The results of our study reflect the increase in iron accumulation and oxidative stress in the SNpc in Parkinson's disease. The decrease in the intensity of SNpc correlates with poor clinical scores.

Dergi Adı NEUROLOGY INDIA
Dergi Cilt Bilgisi 52
Dergi Sayısı 3
Sayfalar 332 - 337
Yayın Yılı 2004
Eser Adı
[dc.title]
T2-weighted MRI in Parkinson's disease; Substantia-nigra pars compacta hypointensity correlates with the clinical scores
Yazar
[dc.contributor.author]
Atasoy, HT
Yazar
[dc.contributor.author]
Nuyan, O
Yazar
[dc.contributor.author]
Tunc, T
Yazar
[dc.contributor.author]
Yorubulut, M
Yazar
[dc.contributor.author]
Unal, AE
Yazar
[dc.contributor.author]
Inan, LE
Yayın Yılı
[dc.date.issued]
2004
Yayıncı
[dc.publisher]
WOLTERS KLUWER MEDKNOW PUBLICATIONS
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Background: Iron accumulation in substantia nigra. pars compacta (SNpc) and related intensity and volumetric changes in patients with idiopathic Parkinson's disease (PD) has been reported previously. There are only a few studies evaluating the relation between neuroradiological findings and clinical scores, with contradictory results. Alms: In this study we aimed to measure the iron-rich brain areas of PD patients and healthy subjects with T2-weighted magnetic resonance imaging (MRI) and to evaluate the relation between the clinical scores of PD patients and these imaging results. Methods and Materials: T2-weighted MRI findings were studied in 20 patients with PD and 16 healthy controls. The width of SNpc, putamen volume, and the intensity of the basal ganglia were measured. Unified Parkinson's Disease Rating Scale (UPDRS) was used for evaluating the clinical status. Statistical Analyses: Mann Whitney U test for group comparisons, Wilcoxon sign rank test for comparisons within the patient group, and Spearman's rank correlation coefficient for analyses of correlations were used. Results: Mean SNpc and dentate nucleus intensities were lower in PD patients than healthy subjects. Mean SNpc width and putamen volumes were lower in patients. Decrease in the intensity of mean SNpc correlated with high UPDRS and rigidity scores. Conclusion: The results of our study reflect the increase in iron accumulation and oxidative stress in the SNpc in Parkinson's disease. The decrease in the intensity of SNpc correlates with poor clinical scores.
Açıklama
[dc.description]
WOS: 000224716800006
Açıklama
[dc.description]
PubMed: 15472421
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Parkinson's disease
Konu Başlıkları
[dc.subject]
magnetic resonance imaging
Konu Başlıkları
[dc.subject]
susbstantia nigra
Konu Başlıkları
[dc.subject]
dentate nucleus
Konu Başlıkları
[dc.subject]
iron
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0028-3886
ISSN
[dc.identifier.issn]
1998-4022
İlk Sayfa Sayısı
[dc.identifier.startpage]
332
Son Sayfa Sayısı
[dc.identifier.endpage]
337
Dergi Adı
[dc.relation.journal]
NEUROLOGY INDIA
Dergi Sayısı
[dc.identifier.issue]
3
Dergi Cilt Bilgisi
[dc.identifier.volume]
52
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/3427
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
13
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
08 Şubat 2024 05:21
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Tıklayınız
patients intensity clinical scores healthy results Parkinson relation between T2-weighted findings imaging subjects evaluating comparisons accumulation putamen disease (UPDRS) status Statistical Analyses Wilcoxon within Whitney Background patient correlates decrease stress oxidative increase reflect Conclusion rigidity
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