The impact of the IL-1 beta, IL-1Ra, IL-2, IL-6 and IL-10 gene polymorphisms on the development of Behcet's disease and their association with the phenotype

Background and objective: This trial was designed to investigate the effects of the interleukin (IL)-1 beta, IL-1Ra, IL-2, IL-6, IL-10 gene polymorphisms on Behcet's disease (BD) occurrence and the association between the polymorphisms and the phenotype. Materials and method: The study population consisted of 71 patients and 70 age and gender-matched healthy subjects. Each of the participants had 2cc of blood withdrawn, which was placed into a whole blood tube, and the DNA was obtained using the NucleoSpin (R) Blood DNA Isolation kit. To display the band lengths, the products were amplified using the primary pairs of the interleukins investigated and developed in a 2% agarose gel. Results: There were no significant differences between the groups with respect to the IL-1Ra, IL-1 beta, IL-2, IL-6 and the IL-10 gene polymorphism distributions. In the patient group the IL-1RN2 gene polymorphism was detected to be statistically correlated with the presence of articular involvement (p = 0.0283) and the IL-1 beta gene polymorphism was statistically correlated with the presence of an ocular lesion (p = 0.0178). The evaluation of the IL-2 gene polymorphism (p = 0.0065) and IL-10 gene polymorphism (p = 0.0483) distributions with respect to age of BD onset revealed a statistically significant distribution. Conclusion: The statistical correlations between the articular involvement and IL-1RN, the ocular involvement and the IL-1 beta, and the age of disease onset and the IL-2 and IL-10 gene polymorphisms, detected for the first time in the literature, suggest that these polymorphisms could be statistically associated with the disease symptoms and used as prognostic factors. Crown Copyright (C) 2015 Published by Elsevier Espana, S.L.U. All rights reserved.

Yazar Baris, Savas
Akyurek, Omer
Dursun, Ahmet
Akyol, Mesut
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/3606
Tek Biçim Adres 10.1016/j.medcli.2015.09.017
Konu Başlıkları Behcet's disease
IL-1 beta
IL-1Ra
IL-2
IL-6 and IL-10
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı MEDICINA CLINICA
Dergi Cilt Bilgisi 146
Dergi Sayısı 9
Sayfalar 379 - 383
Yayın Yılı 2016
Eser Adı
[dc.title]
The impact of the IL-1 beta, IL-1Ra, IL-2, IL-6 and IL-10 gene polymorphisms on the development of Behcet's disease and their association with the phenotype
Yazar
[dc.contributor.author]
Baris, Savas
Yazar
[dc.contributor.author]
Akyurek, Omer
Yazar
[dc.contributor.author]
Dursun, Ahmet
Yazar
[dc.contributor.author]
Akyol, Mesut
Yayın Yılı
[dc.date.issued]
2016
Yayıncı
[dc.publisher]
ELSEVIER ESPANA SLU
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Background and objective: This trial was designed to investigate the effects of the interleukin (IL)-1 beta, IL-1Ra, IL-2, IL-6, IL-10 gene polymorphisms on Behcet's disease (BD) occurrence and the association between the polymorphisms and the phenotype. Materials and method: The study population consisted of 71 patients and 70 age and gender-matched healthy subjects. Each of the participants had 2cc of blood withdrawn, which was placed into a whole blood tube, and the DNA was obtained using the NucleoSpin (R) Blood DNA Isolation kit. To display the band lengths, the products were amplified using the primary pairs of the interleukins investigated and developed in a 2% agarose gel. Results: There were no significant differences between the groups with respect to the IL-1Ra, IL-1 beta, IL-2, IL-6 and the IL-10 gene polymorphism distributions. In the patient group the IL-1RN2 gene polymorphism was detected to be statistically correlated with the presence of articular involvement (p = 0.0283) and the IL-1 beta gene polymorphism was statistically correlated with the presence of an ocular lesion (p = 0.0178). The evaluation of the IL-2 gene polymorphism (p = 0.0065) and IL-10 gene polymorphism (p = 0.0483) distributions with respect to age of BD onset revealed a statistically significant distribution. Conclusion: The statistical correlations between the articular involvement and IL-1RN, the ocular involvement and the IL-1 beta, and the age of disease onset and the IL-2 and IL-10 gene polymorphisms, detected for the first time in the literature, suggest that these polymorphisms could be statistically associated with the disease symptoms and used as prognostic factors. Crown Copyright (C) 2015 Published by Elsevier Espana, S.L.U. All rights reserved.
Açıklama
[dc.description]
WOS: 000375243000001
Açıklama
[dc.description]
PubMed: 26654556
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Behcet's disease
Konu Başlıkları
[dc.subject]
IL-1 beta
Konu Başlıkları
[dc.subject]
IL-1Ra
Konu Başlıkları
[dc.subject]
IL-2
Konu Başlıkları
[dc.subject]
IL-6 and IL-10
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0025-7753
ISSN
[dc.identifier.issn]
1578-8989
İlk Sayfa Sayısı
[dc.identifier.startpage]
379
Son Sayfa Sayısı
[dc.identifier.endpage]
383
Dergi Adı
[dc.relation.journal]
MEDICINA CLINICA
Dergi Sayısı
[dc.identifier.issue]
9
Dergi Cilt Bilgisi
[dc.identifier.volume]
146
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1016/j.medcli.2015.09.017
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/3606
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
78
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
18 Mayıs 2024 21:33
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Tıklayınız
polymorphism statistically polymorphisms disease involvement between articular ocular respect presence IL-1Ra distributions significant correlated detected IL-1RN2 patient evaluation lesion Background revealed factors reserved rights Espana Elsevier Published Copyright prognostic distribution literature Conclusion statistical correlations IL-1RN
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