A simple discharge risk model for predicting 1-year mortality in hospitalised acute decompansated heart failure patients with reduced ejection fraction

Objective: The risk stratification for prognosis in heart failure is very important for optimal disease management and decision making. The aim of this study was to establish a simple discharge 1-year mortality prediction model by integrating data obtained from demographic characteristics, clinical evaluation, laboratory biomarkers and echocardiographic evaluation of hospitalised heart failure with reduced ejection fraction (HFrEF) patients with acute decompensation. Methods and results: A risk score model was developed based on beta-coefficient number of variables in a multivariable logistic regression model which was created with the use of data on clinical, laboratory, imaging and therapeutic findings of 670 patients (65.4% males, 65 +/- 11 years) who was hospitalised with acute decompensated HFrEF. The mean left ventricular ejection fraction (LVEF) was 26 +/- 9%. Independent predictors of mortality were: age >= 75 years, sodium <130 mEq/L, hepatomegaly at admission, unable to use beta-blocker at discharge and LVEF 20%. The 1-year mortality rate was 7.8% in the study population. The existence of each predictor was scored as 1 point and the discharge risk score identified patients into low (0-1 points), intermediate (2-3 points) and high (4-5 points) risk individuals with 3, 15.6 and 44.4% 1-year mortality rates, respectively. The model performance evaluated by concordance index was 0.74. Conclusions: This simple discharge risk score model for hospitalised acute decompensated HFrEF patients using easily determined demographic characteristics, clinical signs, echocardiographic and laboratory data is a valuable and an easy risk assessment tool to use at point-of-care.

Yazar Karauzum, Kurtulus
Karauzum, Irem
Ural, Dilek
Baydemir, Canan
Aktas, Mujdat
Celikyurt, Umut
Kozdag, Guliz
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/1995
Tek Biçim Adres 10.1080/00015385.2017.1351254
Konu Başlıkları Heart failure
prognosis
risk stratification
mortality
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı ACTA CARDIOLOGICA
Dergi Cilt Bilgisi 73
Dergi Sayısı 2
Sayfalar 164 - 170
Yayın Yılı 2018
Eser Adı
[dc.title]
A simple discharge risk model for predicting 1-year mortality in hospitalised acute decompansated heart failure patients with reduced ejection fraction
Yazar
[dc.contributor.author]
Karauzum, Kurtulus
Yazar
[dc.contributor.author]
Karauzum, Irem
Yazar
[dc.contributor.author]
Ural, Dilek
Yazar
[dc.contributor.author]
Baydemir, Canan
Yazar
[dc.contributor.author]
Aktas, Mujdat
Yazar
[dc.contributor.author]
Celikyurt, Umut
Yazar
[dc.contributor.author]
Kozdag, Guliz
Yayın Yılı
[dc.date.issued]
2018
Yayıncı
[dc.publisher]
TAYLOR & FRANCIS LTD
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Objective: The risk stratification for prognosis in heart failure is very important for optimal disease management and decision making. The aim of this study was to establish a simple discharge 1-year mortality prediction model by integrating data obtained from demographic characteristics, clinical evaluation, laboratory biomarkers and echocardiographic evaluation of hospitalised heart failure with reduced ejection fraction (HFrEF) patients with acute decompensation. Methods and results: A risk score model was developed based on beta-coefficient number of variables in a multivariable logistic regression model which was created with the use of data on clinical, laboratory, imaging and therapeutic findings of 670 patients (65.4% males, 65 +/- 11 years) who was hospitalised with acute decompensated HFrEF. The mean left ventricular ejection fraction (LVEF) was 26 +/- 9%. Independent predictors of mortality were: age >= 75 years, sodium <130 mEq/L, hepatomegaly at admission, unable to use beta-blocker at discharge and LVEF 20%. The 1-year mortality rate was 7.8% in the study population. The existence of each predictor was scored as 1 point and the discharge risk score identified patients into low (0-1 points), intermediate (2-3 points) and high (4-5 points) risk individuals with 3, 15.6 and 44.4% 1-year mortality rates, respectively. The model performance evaluated by concordance index was 0.74. Conclusions: This simple discharge risk score model for hospitalised acute decompensated HFrEF patients using easily determined demographic characteristics, clinical signs, echocardiographic and laboratory data is a valuable and an easy risk assessment tool to use at point-of-care.
Açıklama
[dc.description]
WOS: 000431104400008
Açıklama
[dc.description]
PubMed: 28786775
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Heart failure
Konu Başlıkları
[dc.subject]
prognosis
Konu Başlıkları
[dc.subject]
risk stratification
Konu Başlıkları
[dc.subject]
mortality
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0001-5385
ISSN
[dc.identifier.issn]
1784-973X
İlk Sayfa Sayısı
[dc.identifier.startpage]
164
Son Sayfa Sayısı
[dc.identifier.endpage]
170
Dergi Adı
[dc.relation.journal]
ACTA CARDIOLOGICA
Dergi Sayısı
[dc.identifier.issue]
2
Dergi Cilt Bilgisi
[dc.identifier.volume]
73
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1080/00015385.2017.1351254
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/1995
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
22
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
09 Şubat 2024 21:34
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Tıklayınız
discharge patients mortality 1-year laboratory hospitalised clinical points) characteristics evaluation echocardiographic fraction demographic ejection decompensated simple failure population identified hepatomegaly unable scored admission existence beta-blocker predictor Objective intermediate point-of-care assessment valuable determined easily Conclusions concordance
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