Plateletcrit and red cell-distribution width are independent predictors of the slow coronary flow phenomenon

Background and purpose: Endothelial dysfunction may play a role in the pathogenesis of the slow coronary flow (SCF) phenomenon. A detailed examination of blood cellular components has not been performed for this condition. We investigated the relationship between SCF and whole blood cell counts. Method: Records of 17,315 patients who underwent coronary angiography between January 2006 and December 2012 were evaluated retrospectively. A total of 146 patients with SCF were compared with 148 patients with normal coronary arteries according to demographic data, complete blood count, and biochemical parameters. Results: The following parameters were significantly higher in SCF patients than in patients with normal coronary arteries: percentage of smokers (36.3% vs. 25%, p = 0.036), body mass index (26.69 +/- 2.84 vs. 26.07 +/- 3.15, p = 0.049), white blood cells (WBCs) (7.52 +/- 1.43 x 10(3) mm(-3) vs. 7.01 +/- 1.42 x 10(3) mm(-3), p = 0.002), red cell distribution width (RDW) (13.68 +/- 1.42% vs. 13.15 +/- 1.13%, p < 0.001), platelets (250.29 +/- 50.96 x 10(3) mm(-3) vs. 226.10 +/- 38.02 x 10(3) mm(-3), p < 0.001), plateletcrit (PCT) (0.214 +/- 0.40% vs. 0.184 +/- 0.29%, p < 0.001), mean platelet volume (8.63 +/- 1.10 fL vs. 8.22 +/- 0.83 fL, p < 0.001), platelet distribution width (PDW) (16.58 +/- 0.76% vs. 16.45 +/- 0.57%, p = 0.028), and neutrophils (4.44 +/- 1.25 x 10(3) mm(-3) vs. 4.12 +/- 1.24 x 10(3) mm(-3), p = 0.029). Positive PCT values [odds ratio (OR), 4.165; 95% confidence interval (CI), 2.493-6.959; p < 0.001) and RDW (OR, 1.304; 95% Cl, 1.034-1.645; p = 0.025) were independent predictors of SCF. Conclusion: Although within the normal range, the increased numbers of WBCs and neutrophils in patients with SCF suggest that SCF may be a subclinical inflammatory condition. Furthermore, increased RDW and PDW in SCF patients may cause microvascular blood flow resistance due to impaired cell deformability. The PCT provides reliable data regarding total platelet mass and may be a useful predictor of SCF. (C) 2013 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.

Yazar Akpinar, Ibrahim
Sayin, Muhammet Rasit
Gursoy, Yusuf Cemil
Aktop, Ziyaeddin
Karabag, Turgut
Kucuk, Emrah
Sen, Nihat
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/3103
Tek Biçim Adres 10.1016/j.jjcc.2013.07.010
Konu Başlıkları Plateletcrit
Red cell distribution
Slow coronary flow
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı JOURNAL OF CARDIOLOGY
Dergi Cilt Bilgisi 63
Dergi Sayısı 01.Feb
Sayfalar 112 - 118
Yayın Yılı 2014
Eser Adı
[dc.title]
Plateletcrit and red cell-distribution width are independent predictors of the slow coronary flow phenomenon
Yazar
[dc.contributor.author]
Akpinar, Ibrahim
Yazar
[dc.contributor.author]
Sayin, Muhammet Rasit
Yazar
[dc.contributor.author]
Gursoy, Yusuf Cemil
Yazar
[dc.contributor.author]
Aktop, Ziyaeddin
Yazar
[dc.contributor.author]
Karabag, Turgut
Yazar
[dc.contributor.author]
Kucuk, Emrah
Yazar
[dc.contributor.author]
Sen, Nihat
Yayın Yılı
[dc.date.issued]
2014
Yayıncı
[dc.publisher]
ELSEVIER
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Background and purpose: Endothelial dysfunction may play a role in the pathogenesis of the slow coronary flow (SCF) phenomenon. A detailed examination of blood cellular components has not been performed for this condition. We investigated the relationship between SCF and whole blood cell counts. Method: Records of 17,315 patients who underwent coronary angiography between January 2006 and December 2012 were evaluated retrospectively. A total of 146 patients with SCF were compared with 148 patients with normal coronary arteries according to demographic data, complete blood count, and biochemical parameters. Results: The following parameters were significantly higher in SCF patients than in patients with normal coronary arteries: percentage of smokers (36.3% vs. 25%, p = 0.036), body mass index (26.69 +/- 2.84 vs. 26.07 +/- 3.15, p = 0.049), white blood cells (WBCs) (7.52 +/- 1.43 x 10(3) mm(-3) vs. 7.01 +/- 1.42 x 10(3) mm(-3), p = 0.002), red cell distribution width (RDW) (13.68 +/- 1.42% vs. 13.15 +/- 1.13%, p < 0.001), platelets (250.29 +/- 50.96 x 10(3) mm(-3) vs. 226.10 +/- 38.02 x 10(3) mm(-3), p < 0.001), plateletcrit (PCT) (0.214 +/- 0.40% vs. 0.184 +/- 0.29%, p < 0.001), mean platelet volume (8.63 +/- 1.10 fL vs. 8.22 +/- 0.83 fL, p < 0.001), platelet distribution width (PDW) (16.58 +/- 0.76% vs. 16.45 +/- 0.57%, p = 0.028), and neutrophils (4.44 +/- 1.25 x 10(3) mm(-3) vs. 4.12 +/- 1.24 x 10(3) mm(-3), p = 0.029). Positive PCT values [odds ratio (OR), 4.165; 95% confidence interval (CI), 2.493-6.959; p < 0.001) and RDW (OR, 1.304; 95% Cl, 1.034-1.645; p = 0.025) were independent predictors of SCF. Conclusion: Although within the normal range, the increased numbers of WBCs and neutrophils in patients with SCF suggest that SCF may be a subclinical inflammatory condition. Furthermore, increased RDW and PDW in SCF patients may cause microvascular blood flow resistance due to impaired cell deformability. The PCT provides reliable data regarding total platelet mass and may be a useful predictor of SCF. (C) 2013 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.
Açıklama
[dc.description]
WOS: 000331424100021
Açıklama
[dc.description]
PubMed: 24012331
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Plateletcrit
Konu Başlıkları
[dc.subject]
Red cell distribution
Konu Başlıkları
[dc.subject]
Slow coronary flow
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
0914-5087
ISSN
[dc.identifier.issn]
1876-4738
İlk Sayfa Sayısı
[dc.identifier.startpage]
112
Son Sayfa Sayısı
[dc.identifier.endpage]
118
Dergi Adı
[dc.relation.journal]
JOURNAL OF CARDIOLOGY
Dergi Sayısı
[dc.identifier.issue]
01.Feb
Dergi Cilt Bilgisi
[dc.identifier.volume]
63
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1016/j.jjcc.2013.07.010
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/3103
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
21
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
08 Şubat 2024 07:11
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patients mm(-3) coronary platelet normal arteries neutrophils increased between parameters condition distribution values Positive volume Background microvascular resistance impaired deformability provides reliable regarding useful predictor Japanese College Cardiology Published Elsevier rights reserved Furthermore confidence interval
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