Expression of histamine receptors (H-1, H-2, and H-3) in the rabbit endolymphatic sac: an immunohistochemical study

Objective: The endolymphatic sac (ES) is part of the membranous labyrinth of the inner ear. Its central role in immunologic activity within the inner ear has been confirmed by numerous studies. The aim of this study was to investigate the expression of histamine receptors (H-1, H-2, H-3) in the rabbit ES. Methods: A total of 10 healthy male New Zealand white rabbits weighing 2 to 3 kg were used in the experiments. For immunohistochemical studies, immunostaining was performed according to the avidin-biotin-peroxidase complex technique. Results: Serial sections of the ES of rabbits revealed the presence of H-1, H-2, and H-3 receptor immunoreactivity. Immunoreactive cells for all H-1, H-2, and H-3 were found in the epithelial and subepithelial layers of the duct and the proximal ES. In conclusion, this study showed the immunohistochemical localization of H-1, H-2, and H-3 receptors in the ES of rabbits. These receptors may be important in the homeostasis of the inner ear. In addition, they may be target receptors in the medical treatment of inner car disorders such as endolymphatic hydrops. (C) 2008 Published by Elsevier Inc.

Yazar Dagli, Muharrem
Goksu, Nebil
Eryilmaz, Adil
Kuzey, Gamze Mocan
Bayazit, Yildirim
Gun, Banu Dogan
Gocer, Cehl
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/2627
Tek Biçim Adres 10.1016/j.amjoto.2006.12.003
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı AMERICAN JOURNAL OF OTOLARYNGOLOGY
Dergi Cilt Bilgisi 29
Dergi Sayısı 1
Sayfalar 20 - 23
Yayın Yılı 2008
Eser Adı
[dc.title]
Expression of histamine receptors (H-1, H-2, and H-3) in the rabbit endolymphatic sac: an immunohistochemical study
Yazar
[dc.contributor.author]
Dagli, Muharrem
Yazar
[dc.contributor.author]
Goksu, Nebil
Yazar
[dc.contributor.author]
Eryilmaz, Adil
Yazar
[dc.contributor.author]
Kuzey, Gamze Mocan
Yazar
[dc.contributor.author]
Bayazit, Yildirim
Yazar
[dc.contributor.author]
Gun, Banu Dogan
Yazar
[dc.contributor.author]
Gocer, Cehl
Yayın Yılı
[dc.date.issued]
2008
Yayıncı
[dc.publisher]
W B SAUNDERS CO-ELSEVIER INC
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Objective: The endolymphatic sac (ES) is part of the membranous labyrinth of the inner ear. Its central role in immunologic activity within the inner ear has been confirmed by numerous studies. The aim of this study was to investigate the expression of histamine receptors (H-1, H-2, H-3) in the rabbit ES. Methods: A total of 10 healthy male New Zealand white rabbits weighing 2 to 3 kg were used in the experiments. For immunohistochemical studies, immunostaining was performed according to the avidin-biotin-peroxidase complex technique. Results: Serial sections of the ES of rabbits revealed the presence of H-1, H-2, and H-3 receptor immunoreactivity. Immunoreactive cells for all H-1, H-2, and H-3 were found in the epithelial and subepithelial layers of the duct and the proximal ES. In conclusion, this study showed the immunohistochemical localization of H-1, H-2, and H-3 receptors in the ES of rabbits. These receptors may be important in the homeostasis of the inner ear. In addition, they may be target receptors in the medical treatment of inner car disorders such as endolymphatic hydrops. (C) 2008 Published by Elsevier Inc.
Açıklama
[dc.description]
WOS: 000251743600004
Açıklama
[dc.description]
PubMed: 18061827
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0196-0709
ISSN
[dc.identifier.issn]
1532-818X
İlk Sayfa Sayısı
[dc.identifier.startpage]
20
Son Sayfa Sayısı
[dc.identifier.endpage]
23
Dergi Adı
[dc.relation.journal]
AMERICAN JOURNAL OF OTOLARYNGOLOGY
Dergi Sayısı
[dc.identifier.issue]
1
Dergi Cilt Bilgisi
[dc.identifier.volume]
29
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1016/j.amjoto.2006.12.003
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2627
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
20
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
26 Aralık 2023 15:15
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Tıklayınız
receptors rabbits immunohistochemical studies endolymphatic addition immunoreactivity Immunoreactive Published receptor subepithelial Elsevier presence revealed sections epithelial layers homeostasis disorders important target medical treatment Results localization showed conclusion hydrops proximal Serial Objective technique activity expression investigate
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