Prolonged retention and in vivo evaluation of cationic nanoparticles loaded with Mitomycin C designed for intravesical chemotherapy of bladder tumours

To overcome the recurrence problem in bladder tumours; nanoparticles with positive surface charge may improve interaction with biological membranes for intravesical administration. The aim of this study was to design, develop and evaluate (in vitro-in vivo) cationic nanoparticles based on chitosan, poly-L-lysine or polycaprolactone for the effective intravesical delivery of chemotherapeutic agent MMC in a rat model. Poly-L-lysine-coated polycaprolactone nanoparticles and chitosan-coated polycaprolactone nanoparticles were prepared by the double emulsion technique. Chitosan nanoparticles were prepared by ionic gelation. It was found that nanoparticle formulations of 160-320nm in size can be produced in 14-35% encapsulation efficiency. Variability in the particle size of nanoparticles depended on the preparation method. Encapsulation was increased by two-fold for CS-PCL as a result of the double emulsion technique. Commercial MMC product in solution form and cationic nanoparticle formulations were compared for in vivo bladder retention properties and effect of formulations on urine volume.

Dergi Adı JOURNAL OF MICROENCAPSULATION
Dergi Cilt Bilgisi 29
Dergi Sayısı 6
Sayfalar 576 - 582
Yayın Yılı 2012
Eser Adı
[dc.title]
Prolonged retention and in vivo evaluation of cationic nanoparticles loaded with Mitomycin C designed for intravesical chemotherapy of bladder tumours
Yazar
[dc.contributor.author]
Erdogar, Nazli
Yazar
[dc.contributor.author]
Iskit, Alper B.
Yazar
[dc.contributor.author]
Mungan, N. Aydin
Yazar
[dc.contributor.author]
Bilensoy, Erem
Yayın Yılı
[dc.date.issued]
2012
Yayıncı
[dc.publisher]
TAYLOR & FRANCIS LTD
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
To overcome the recurrence problem in bladder tumours; nanoparticles with positive surface charge may improve interaction with biological membranes for intravesical administration. The aim of this study was to design, develop and evaluate (in vitro-in vivo) cationic nanoparticles based on chitosan, poly-L-lysine or polycaprolactone for the effective intravesical delivery of chemotherapeutic agent MMC in a rat model. Poly-L-lysine-coated polycaprolactone nanoparticles and chitosan-coated polycaprolactone nanoparticles were prepared by the double emulsion technique. Chitosan nanoparticles were prepared by ionic gelation. It was found that nanoparticle formulations of 160-320nm in size can be produced in 14-35% encapsulation efficiency. Variability in the particle size of nanoparticles depended on the preparation method. Encapsulation was increased by two-fold for CS-PCL as a result of the double emulsion technique. Commercial MMC product in solution form and cationic nanoparticle formulations were compared for in vivo bladder retention properties and effect of formulations on urine volume.
Açıklama
[dc.description]
WOS: 000307999000008
Açıklama
[dc.description]
PubMed: 22468630
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
bladder cancer
Konu Başlıkları
[dc.subject]
bladder retention
Konu Başlıkları
[dc.subject]
cationic nanoparticles
Konu Başlıkları
[dc.subject]
chitosan
Konu Başlıkları
[dc.subject]
intravesical drug delivery
Konu Başlıkları
[dc.subject]
poly-epsilon-caprolactone
Konu Başlıkları
[dc.subject]
poly-L-lysine
Konu Başlıkları
[dc.subject]
rat model
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0265-2048
ISSN
[dc.identifier.issn]
1464-5246
Sponsor YAYINCI
[dc.description.sponsorship]
TUBITAKTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [109S172]; Turkish Academy of SciencesTurkish Academy of Sciences [EA-TUBA-GEBIP/2001-2-11]
Sponsor YAYINCI
[dc.description.sponsorship]
Authors would like to acknowledge that this project was financially supported by TUBITAK (Scientific Research Project Number: 109S172). Alper B. Iskit has been supported by the Turkish Academy of Sciences, in the framework of the Young Scientist Award Program (EA-TUBA-GEBIP/2001-2-11).
İlk Sayfa Sayısı
[dc.identifier.startpage]
576
Son Sayfa Sayısı
[dc.identifier.endpage]
582
Dergi Adı
[dc.relation.journal]
JOURNAL OF MICROENCAPSULATION
Dergi Sayısı
[dc.identifier.issue]
6
Dergi Cilt Bilgisi
[dc.identifier.volume]
29
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.3109/02652048.2012.668957
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/3174
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
44
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
14 Şubat 2024 09:58
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Tıklayınız
nanoparticles polycaprolactone formulations intravesical technique cationic nanoparticle prepared bladder double emulsion 160-320nm produced 14-35% encapsulation efficiency product volume effect properties retention compared solution Commercial Variability result CS-PCL two-fold increased Encapsulation gelation preparation depended particle method
6698 sayılı Kişisel Verilerin Korunması Kanunu kapsamında yükümlülüklerimiz ve çerez politikamız hakkında bilgi sahibi olmak için alttaki bağlantıyı kullanabilirsiniz.

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