Use of warm priming solution in open heart surgery: its effects on hemodynamics and acute inflammation

Cardiac surgery causes an acute inflammatory response and organ damage. In this study, for the first time in the literature, we compared the effects of priming solutions at 20 degrees C and 36 degrees C on acute inflammatory markers and hemo-dynamic parameters. Forty patients were recruited and randomized into two groups, each consisting of 20 participants who underwent elective coronary artery bypass grafting operation. Groups were primed with the same solution at different temperatures. Hemodynamic parameters were recorded. Blood samples were drawn pre-operatively and at the 15(th) and 60(th) minutes of aortic cross-clamping and the 24(th) hour following surgery. Serum pre-albumin, alpha-1 antitrypsin, and tumor necrosis factor-alpha levels were determined. The groups were compared statistically. Both of the groups were comparable for mean aortic cross-clamping time and mean time for cardiopulmonary bypass. Mean blood pressure value was significantly lower and the mean amount of ephedrine hydrochloride used was significantly higher in the cold priming group. Spontaneous beating of the heart after removal of aortic cross-clamp significantly was more frequent in the warm priming group. A significant rise was observed in systemic inflammatory markers in the cold priming group. In our study, the lesser amount of ephedrine hydrochloride used and the higher frequency of spontneous beating of the heart in the warm priming group may be considered as improvements in hemodynamic status. Use of warm priming solution also induced a significant improvement in the acute inflammatory markers. We recommend the use of warm priming solution in open heart surgery.

Yazar Buyukates, M.
Acikgoz, S.
Kandemir, O.
Aktunc, E.
Ceylan, E.
Can, M.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/3756
Tek Biçim Adres 10.1177/0267659108094798
Konu Başlıkları acute inflammation
cardiopulmonary bypass
priming solution
temperature
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı PERFUSION-UK
Dergi Cilt Bilgisi 23
Dergi Sayısı 2
Sayfalar 89 - 94
Yayın Yılı 2008
Eser Adı
[dc.title]
Use of warm priming solution in open heart surgery: its effects on hemodynamics and acute inflammation
Yazar
[dc.contributor.author]
Buyukates, M.
Yazar
[dc.contributor.author]
Acikgoz, S.
Yazar
[dc.contributor.author]
Kandemir, O.
Yazar
[dc.contributor.author]
Aktunc, E.
Yazar
[dc.contributor.author]
Ceylan, E.
Yazar
[dc.contributor.author]
Can, M.
Yayın Yılı
[dc.date.issued]
2008
Yayıncı
[dc.publisher]
SAGE PUBLICATIONS LTD
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Cardiac surgery causes an acute inflammatory response and organ damage. In this study, for the first time in the literature, we compared the effects of priming solutions at 20 degrees C and 36 degrees C on acute inflammatory markers and hemo-dynamic parameters. Forty patients were recruited and randomized into two groups, each consisting of 20 participants who underwent elective coronary artery bypass grafting operation. Groups were primed with the same solution at different temperatures. Hemodynamic parameters were recorded. Blood samples were drawn pre-operatively and at the 15(th) and 60(th) minutes of aortic cross-clamping and the 24(th) hour following surgery. Serum pre-albumin, alpha-1 antitrypsin, and tumor necrosis factor-alpha levels were determined. The groups were compared statistically. Both of the groups were comparable for mean aortic cross-clamping time and mean time for cardiopulmonary bypass. Mean blood pressure value was significantly lower and the mean amount of ephedrine hydrochloride used was significantly higher in the cold priming group. Spontaneous beating of the heart after removal of aortic cross-clamp significantly was more frequent in the warm priming group. A significant rise was observed in systemic inflammatory markers in the cold priming group. In our study, the lesser amount of ephedrine hydrochloride used and the higher frequency of spontneous beating of the heart in the warm priming group may be considered as improvements in hemodynamic status. Use of warm priming solution also induced a significant improvement in the acute inflammatory markers. We recommend the use of warm priming solution in open heart surgery.
Açıklama
[dc.description]
WOS: 000259620100003
Açıklama
[dc.description]
PubMed: 18840576
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
acute inflammation
Konu Başlıkları
[dc.subject]
cardiopulmonary bypass
Konu Başlıkları
[dc.subject]
priming solution
Konu Başlıkları
[dc.subject]
temperature
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0267-6591
İlk Sayfa Sayısı
[dc.identifier.startpage]
89
Son Sayfa Sayısı
[dc.identifier.endpage]
94
Dergi Adı
[dc.relation.journal]
PERFUSION-UK
Dergi Sayısı
[dc.identifier.issue]
2
Dergi Cilt Bilgisi
[dc.identifier.volume]
23
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1177/0267659108094798
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/3756
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
19
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
08 Nisan 2024 05:10
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Tıklayınız
priming inflammatory surgery significantly aortic markers solution groups higher hydrochloride ephedrine significant amount parameters beating bypass cross-clamping compared degrees statistically comparable Spontaneous cardiopulmonary pressure Cardiac removal recommend improvement induced status hemodynamic improvements considered cross-clamp spontneous
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