Partial HELLP syndrome: Maternal, perinatal, subsequent pregnancy and long-term maternal outcomes

AimsHemolysis, elevated liver enzymes and low platelet count (HELLP) syndrome, in its complete form, is associated with increased risk of maternal mortality and increased rate of serious obstetric complications, such as acute renal failure, hepatic failure, abruptio placentae, pulmonary edema, sepsis, hemorrhage and disseminated intravascular coagulopathy. To compare maternal and perinatal outcomes, we investigated the subsequent pregnancy outcomes and long-term complications of women with partial HELLP (pHELLP) and complete HELLP (cHELLP) syndromes. Material and MethodsIn this retrospective study, patients complicated with HELLP between the years 2002 and 2007 were analyzed. cHELLP syndrome was defined by the presence of all of the three laboratory criteria according to the Tennessee Classification System. pHELLP syndrome was defined by the presence of one or two features of HELLP, but not the complete form. ResultsSixty-four patients had cHELLP syndrome and 67 had pHELLP syndrome. Maternal complications and neonatal outcomes of the indexed pregnancies were similar. The rate of blood product transfusion was significantly higher in the cHELLP group (P<0.0001). Twenty-eight patients within the cHELLP group and 26 within the pHELLP group had subsequent pregnancies with a mean interpregnancy interval of 2.91.5 years and 2.4 +/- 1.1 years, respectively. Elective termination of pregnancy (dilatation and curettage) was more frequent in the cHELLP group. Pre-eclampsia recurrence was higher in the pHELLP group than in the cHELLP group (7.1% vs 34.6%). ConclusionsPartial and complete HELLP syndrome are not distinct groups based on neonatal, long-term and subsequent pregnancy outcomes. They probably represent a continuum in the natural evolution of the same disease.

Yazar Aydin, Serdar
Ersan, Firat
Ark, Cemal
Aydin, Cagri Arioglu
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/3068
Tek Biçim Adres 10.1111/jog.12295
Konu Başlıkları HELLP
partial HELLP
pre-eclampsia
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
Dergi Cilt Bilgisi 40
Dergi Sayısı 4
Sayfalar 932 - 940
Yayın Yılı 2014
Eser Adı
[dc.title]
Partial HELLP syndrome: Maternal, perinatal, subsequent pregnancy and long-term maternal outcomes
Yazar
[dc.contributor.author]
Aydin, Serdar
Yazar
[dc.contributor.author]
Ersan, Firat
Yazar
[dc.contributor.author]
Ark, Cemal
Yazar
[dc.contributor.author]
Aydin, Cagri Arioglu
Yayın Yılı
[dc.date.issued]
2014
Yayıncı
[dc.publisher]
WILEY-BLACKWELL
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
AimsHemolysis, elevated liver enzymes and low platelet count (HELLP) syndrome, in its complete form, is associated with increased risk of maternal mortality and increased rate of serious obstetric complications, such as acute renal failure, hepatic failure, abruptio placentae, pulmonary edema, sepsis, hemorrhage and disseminated intravascular coagulopathy. To compare maternal and perinatal outcomes, we investigated the subsequent pregnancy outcomes and long-term complications of women with partial HELLP (pHELLP) and complete HELLP (cHELLP) syndromes. Material and MethodsIn this retrospective study, patients complicated with HELLP between the years 2002 and 2007 were analyzed. cHELLP syndrome was defined by the presence of all of the three laboratory criteria according to the Tennessee Classification System. pHELLP syndrome was defined by the presence of one or two features of HELLP, but not the complete form. ResultsSixty-four patients had cHELLP syndrome and 67 had pHELLP syndrome. Maternal complications and neonatal outcomes of the indexed pregnancies were similar. The rate of blood product transfusion was significantly higher in the cHELLP group (P<0.0001). Twenty-eight patients within the cHELLP group and 26 within the pHELLP group had subsequent pregnancies with a mean interpregnancy interval of 2.91.5 years and 2.4 +/- 1.1 years, respectively. Elective termination of pregnancy (dilatation and curettage) was more frequent in the cHELLP group. Pre-eclampsia recurrence was higher in the pHELLP group than in the cHELLP group (7.1% vs 34.6%). ConclusionsPartial and complete HELLP syndrome are not distinct groups based on neonatal, long-term and subsequent pregnancy outcomes. They probably represent a continuum in the natural evolution of the same disease.
Açıklama
[dc.description]
WOS: 000333615200005
Açıklama
[dc.description]
PubMed: 24612188
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
HELLP
Konu Başlıkları
[dc.subject]
partial HELLP
Konu Başlıkları
[dc.subject]
pre-eclampsia
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
1341-8076
ISSN
[dc.identifier.issn]
1447-0756
İlk Sayfa Sayısı
[dc.identifier.startpage]
932
Son Sayfa Sayısı
[dc.identifier.endpage]
940
Dergi Adı
[dc.relation.journal]
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
Dergi Sayısı
[dc.identifier.issue]
4
Dergi Cilt Bilgisi
[dc.identifier.volume]
40
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1111/jog.12295
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/3068
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
17
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
09 Şubat 2024 05:00
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Tıklayınız
cHELLP syndrome outcomes complete pHELLP complications subsequent pregnancy patients failure higher within long-term defined presence maternal increased neonatal pregnancies transfusion interpregnancy Maternal indexed similar Twenty-eight product significantly AimsHemolysis interval disease evolution natural continuum represent probably
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