Effects of Impaired Fasting Glucose on Aortic Elasticity

Background: The pathophysiology of atherosclerosis development in patients with diabetes mellitus (DM) is similar to that in nondiabetics. However, atherosclerosis develops earlier and runs a rapid course in patients with diabetes. Aortic stiffness, strain and distensibility are the parameters used to assess an increase in arterial stiffness and can be measured by invasive and non-invasive methods. Method: Aortic elastic properties were compared among patients with normal oral glucose tolerance test but impaired fasting glucose and healthy individuals. The study group consisted of 50 subjects with impaired fasting glucose who had no known risk factors for atherosclerosis. The control group was composed of the same number of volunteers. Results: It was found that aortic strain and distensibility were reduced (8.78 +/- 4.3 vs. 10.65 +/- 2.6 p<0.01 and 4.1 +/- 2.1 vs. 5.1 +/- 1.7 p<0.01 respectively) and aortic stiffness index was significantly increased (6.9 +/- 3.2 vs. 5.01 +/- 1.6, p<0.0001) in patients with impaired fasting glucose compared to those in the control group. Conclusions: It was demonstrated that aortic elasticity was impaired in those with impaired fasting glucose, which indicates that these patients should be kept under close follow-up for cardiovascular events.

Dergi Adı EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
Dergi Cilt Bilgisi 120
Dergi Sayısı 7
Sayfalar 424 - 427
Yayın Yılı 2012
Eser Adı
[dc.title]
Effects of Impaired Fasting Glucose on Aortic Elasticity
Yazar
[dc.contributor.author]
Dogan, S. M.
Yazar
[dc.contributor.author]
Aktop, Z.
Yazar
[dc.contributor.author]
Aydin, M.
Yazar
[dc.contributor.author]
Karabag, T.
Yazar
[dc.contributor.author]
Sayin, M. R.
Yazar
[dc.contributor.author]
Bilici, H. M.
Yazar
[dc.contributor.author]
Atmaca, H.
Yayın Yılı
[dc.date.issued]
2012
Yayıncı
[dc.publisher]
JOHANN AMBROSIUS BARTH VERLAG MEDIZINVERLAGE HEIDELBERG GMBH
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Background: The pathophysiology of atherosclerosis development in patients with diabetes mellitus (DM) is similar to that in nondiabetics. However, atherosclerosis develops earlier and runs a rapid course in patients with diabetes. Aortic stiffness, strain and distensibility are the parameters used to assess an increase in arterial stiffness and can be measured by invasive and non-invasive methods. Method: Aortic elastic properties were compared among patients with normal oral glucose tolerance test but impaired fasting glucose and healthy individuals. The study group consisted of 50 subjects with impaired fasting glucose who had no known risk factors for atherosclerosis. The control group was composed of the same number of volunteers. Results: It was found that aortic strain and distensibility were reduced (8.78 +/- 4.3 vs. 10.65 +/- 2.6 p<0.01 and 4.1 +/- 2.1 vs. 5.1 +/- 1.7 p<0.01 respectively) and aortic stiffness index was significantly increased (6.9 +/- 3.2 vs. 5.01 +/- 1.6, p<0.0001) in patients with impaired fasting glucose compared to those in the control group. Conclusions: It was demonstrated that aortic elasticity was impaired in those with impaired fasting glucose, which indicates that these patients should be kept under close follow-up for cardiovascular events.
Açıklama
[dc.description]
WOS: 000307808100009
Açıklama
[dc.description]
PubMed: 22576258
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
impaired fasting glucose
Konu Başlıkları
[dc.subject]
prediabetes
Konu Başlıkları
[dc.subject]
aortic stiffness
Konu Başlıkları
[dc.subject]
strain
Konu Başlıkları
[dc.subject]
distensibility
Konu Başlıkları
[dc.subject]
cardiovascular risk
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
0947-7349
ISSN
[dc.identifier.issn]
1439-3646
İlk Sayfa Sayısı
[dc.identifier.startpage]
424
Son Sayfa Sayısı
[dc.identifier.endpage]
427
Dergi Adı
[dc.relation.journal]
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
Dergi Sayısı
[dc.identifier.issue]
7
Dergi Cilt Bilgisi
[dc.identifier.volume]
120
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1055/s-0032-1306295
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2491
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
28
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
07 Nisan 2024 05:01
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Tıklayınız
glucose patients impaired fasting stiffness aortic atherosclerosis control distensibility diabetes compared Aortic strain reduced Results volunteers number composed Background events cardiovascular follow-up should indicates elasticity demonstrated Conclusions increased significantly respectively) individuals factors increase assess parameters
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